The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast... - 0 views
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Nathan Goodyear on 21 Jan 14Great article!! Nice discussion of the complexity of hormones. Women on aromatase inhibitors can make estrogen from Testosterone. This is important with estrogen sensitive cancer as in breast cancer. This will occur via alternative pathways: Testosterone to DHT via 5 alpha reductase and then DHT to 3 beta androstanediol via 3 beta HSD. 3 beta androstanediol is a male hormone metabolite that binds to estrogen receptors. The affinity is less than Estradiol, but appears to have a higher affinity for ER beta over ER alpha.