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Study finds that leptin, PAI-1, and hsCRP are positively associated with increasing metabolic syndrome components.  Adiponectin was negative associated with increasing MetS.  Not a lot of new info here.

hsCRP shown to be predictive of cardiovascular disease

Increased fat mass in per pubertal girls is associated with inflammation.  This study evaluated inflammation via hsCRP

diet dominance type favors different bacterial balance in the gut that favors systemic inflammation.  Particularly, a high fat diet is associated with systemic hsCRP.

Testosterone therapy in men with low T found to reduce glucose, aid loss of abdominal adiposity, and reduced hsCRP in men with metabolic syndrome.  This study followed therapy for 24 months.  The authors of this study state that Testosterone levels need to be restored to that of a normal range for young adults to reduce CVD.

Metabolic Syndrome is associated with CAD.  No surprise here, but increase in # of metabolic syndrome parameters was associated with increasing % of Triple vessel disease.   No surprise that MetS was associated with TNF-alpha, IL-6, IR, and hsCRP.

This study looked at oral Testosterone plus fenofibrate (tricor).  That is not the purpose of this post.  This study found that oral Testosterone decanoate reduced hsCRP and improved insulin sensitivity.  One caveat--Testosterone should not be given orally due to increased risk of hepatocellular cancer.

total and bioavailable Estradiol associated with increased hsCRP in men age 40-80.  Bioavailable is calculated with serum calculated free Testosterone and albumin bound Testosterone.

This article finds that Testosterone transdermal therapy addition to Diet and exercise improved glycemic control and reversed Metabolic Syndrome in men with low T and type II Diabetes.  This article really highlights the proper approach to therapy: combined nutrition, exercise, and Testosterone therapy, when indicated, for men with Metabolic Syndrome and/or Diabetes.  A reduction in IR, adiponectin and hsCRP was observed.

Study of men with metabolic syndrome and type II Diabetes finds that diet and exercise alone improved glucose control and metabolic syndrome components by 31%.  The addition of Testosterone therapy increased this % to 81%.

Study of men < 70 finds that low Total Testosterone and Free Testosterone is associated with increased Carotid Intima-media thickness (CIMT), increased endothelial dysfunction.  Atherosclerotic plaque and hsCRP were also found to correlate but were adjusted out when age, DM, HgbA1c, lipids, and BMI were excluded.

increased LP-PLA2 and hsCRP are associated with increased risk of ischemic stroke.

Mediterranean diet found to reduce hsCRP, IL-6, TNF-alpha, and MCP in high-risk adults out to 5 years!  This study compared the Mediterranean diet to a low fat diet.

This study concludes that a energy restricted, high protein diet is more effective at weight loss than just a high protein diet.  There were also positive impacts on blood pressure, glucose, cholesterol, and hsCRP.

Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.   And PSA?  No mention of it here.   This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?   This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

Testosterone therapy in older men with low T found a reduction in CRP.

Study finds that Testosterone is associated with reduced CRP. This association was especially evident in the higher weights.  No association was seen with E2 in this study.

Study of Taiwanese men finds low free Testosterone and hs-CRP is predictive of ED in obese men.

only abstract available, but low Testosterone and elevated hs-CRP are found to predict metabolic syndrome in men.

Interesting, yet not surprising.  TNF-alpha has strong correlation with IR in pregnancy.  This follows metabolic endotoxemia pathophysiology.  I believe this could be used to assess risk for PIH...