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Nathan Goodyear

Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carniti... - 0 views

www.crd.york.ac.uk/...ShowRecord.asp

Acetyl-L-carnitine acetyl Carnitine cognition cognitive decline brain alzheimer disease

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Meta-analysis of 21 studies on acetyl Carnitine finds improvement with mild cognitive impairment and/or prevention of cognitive deterioration.
Nathan Goodyear

Acetyl-L-carnitine treatment increases choline ace... [Brain Res. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8137174

Acetyl-L-carnitine carnitine brain acetylcholine nerve growth factor

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Rat study, but acetyl-L-carnitine shown to increase nerve growth factor.  In addition, it increased acetylcholine activity.
Nathan Goodyear

Oral acetyl-l-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a rand... - 0 views

www.ajcn.org/...799.abstract

Acetyl-L-carnitine fatigue

shared by Nathan Goodyear on 24 May 11 - No Cached
  • decrease in the severity of both mental and physical fatigue and an increase in physical activity
  • Nathan Goodyear on 24 May 11
     
    Acetyl-L-carnitine reduces fatigue
Nathan Goodyear

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasi... - 0 views

www.cell.com/...S1550-4131(17)30570-3

cancer breast cancer epigenetics obesity menopause

shared by Nathan Goodyear on 25 Oct 17 - No Cached
  • Nathan Goodyear on 25 Oct 17
     
    Just abstract available here.  Obesity in menopause is associated with 20-40% increased risk of breast cancer. Obesity also increases risk of metastasis and recurrence.  This new study suggests, one mechanism is via the phosphorylation of the acetyl-CoA carboxylase enzyme.  In part, epigenetics plays a role.
Nathan Goodyear

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3607061

carnitine L-Carnitine Acetyl-L-carnitine depression

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    rat model finds fast, long-lasting benefit of acetyl carnitine in depression.
Nathan Goodyear

Frankincense Effective in Killing Ovarian Cancer Cells, Study : News : University Herald - 0 views

www.universityherald.com/...s-leicester-university-gum.htm

Ovarian cancer Frankincense acetyl-11-keto-beta-boswellic acid boswellia essential oils EO

shared by Nathan Goodyear on 08 Jan 14 - No Cached
  • Nathan Goodyear on 08 Jan 14
     
    Just a statement about in-vitro analysis, but this does fit with the growing body of evidence that Frankincese, particularly the acetyl-11-keto-beta-boswellic acid, has anti-cancer properties.  Wouldn't it be great to be able to fight cancer without killing the patient?
Nathan Goodyear

Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthot... - 0 views

www.ncbi.nlm.nih.gov/...PMC3204996

Frankincense acetyl-11-keto-beta-boswellic acid AKBA cancer

shared by Nathan Goodyear on 06 Jan 15 - No Cached
  • Nathan Goodyear on 06 Jan 15
     
    Study finds that acetyl-11-keto-Beta-boswellic acid (AKBA) reduced growth of pancreatic cancer and metastasis in mouse model.  AKBA also inhibits NF-kappaB and induced apoptosis.  AKBA is found in Frankinsense. 
Nathan Goodyear

Multicentre study of l-alpha-glyceryl-ph... [Drugs Aging. 1993 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8477148

alpha GPC alpha-GPC Acetyl-L-carnitine dementia Alzheimer's disease aging brain

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.
Nathan Goodyear

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tis... - 0 views

www.cell.com/...S1097-2765(16)30670-0

epigenetics diet nutrition SCFA gut gut bacteria gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 28 Nov 16 - No Cached
  • SCFAs play a dual role both as substrates for metabolism and as signaling molecules
  • SCFAs can be either directly converted (acetate) or oxidized (propionate and butyrate) to acetyl-Co
  • Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner
  • ...1 more annotation...
  • complex functional interactions between diet, gut microbiota, and host health.
  • Nathan Goodyear on 28 Nov 16
     
    diet changes gut microbiota, which changes genetic expression--it is called epigenetics.  This is an animal study.
Nathan Goodyear

Curcumin Attenuation of Lipopolysaccharide Induced Cardiac Hypertrophy in Rodents - 0 views

www.hindawi.com/...539305

curcumin LPS lipopolysaccharides epigenetics inflammation heart disease heart health

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    This is just to cool. Curcumin found to inhibit LPS mediated cardiac hypertrophy. The how is fascinating. No only does LPS induce inflammatory cytokine production, but he inflammation induces disease--cardiac hypertrophy. LPS induces epigenetic changes that lead to the hypertrophy. Curcumin blocked the histone acetylation induced by LPS.
Nathan Goodyear

Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxy... - 0 views

vitamin C HIF-1alpha KRAS Pyruvate dehydrogenase kinase colorectal cancer GLUT pyruvate dehydrogenase cancer HIF SVCT

shared by Nathan Goodyear on 16 Mar 21 - No Cached
  • Nathan Goodyear on 16 Mar 21
     
    In KRAS + CRC, vitamin C downregulates PDK GLUT1, thereby increasing PD increasing Acetyl CoA production.
Nathan Goodyear

SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome - 0 views

biomedgerontology.oxfordjournals.org/...105.full

SIRT3 metabolic syndrome mitochondria acetylation high fat diet diet

shared by Nathan Goodyear on 12 Feb 13 - No Cached
  • Nathan Goodyear on 12 Feb 13
     
    SIRT3 activity plays role in the development of metabolic syndrome in those fed a typical American high fat diet.
Nathan Goodyear

ScienceDirect.com - Cell Metabolism - Estrogen Receptors and the Metabolic Network - 0 views

www.sciencedirect.com/...S1550413111003123

ER-alpha ER-beta estrogen receptor receptors metabolic syndrome MetS hormone hormones

shared by Nathan Goodyear on 11 Oct 12 - No Cached
  • The pro-opiomelanocortin (POMC) neurons have an anorexigenic action and, when activated, reduce food intake through the release of two peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine-and-amphetamine-regulated transcripts (CART). The neuropeptide Y (NPY) neurons, on the other hand, release NPY hormone and agouti gene-related protein (AgRP), which prevent the binding of α-MSH to MC3R and MC4R, increasing food intake
  • This suggests that the central anorexic effects of E2 may occur via ERβ
  • The main hypothalamic areas involved in food intake and satiety are the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), the ventromedial hypothalamus (VMH), and the dorsomedial hypothalamus (DMH)
  • ...22 more annotations...
  • Leptin is a potent anorexigenic and catabolic hormone secreted by adipose cells that reduces food intake and increases energy expenditure
  • E2 not only modulates leptin receptor mRNA in the ARC and VMH, but also increases hypothalamic sensitivity to leptin, altering peripheral fat distribution
  • ghrelin. It acts on growth hormone secretagogue receptors (GHSR1a) located in the ARC and is a potent stimulator of food intake
  • It thus appears that of the two ERs, ERα plays a predominant role in the CNS regulation of lipid and carbohydrate homeostasis.
  • Both ERs have been identified in the ARC
  • Stimulation of MCH neurons increases food intake and fat accumulation while its inhibition leads to decreased food intake and reduced fat accumulation.
  • Both ERs have been identified in the LH
  • both ERs have been identified in this nucleus
  • The PVN is the region of the hypothalamus with the highest expression of ERβ and is reported to be weakly ERα positive
  • The VMH is ERα regulated
  • Skeletal muscle is responsible for 75% of the insulin-induced glucose uptake in the body
  • GLUT4 is highly expressed in muscle and represents a rate-limiting step in the insulin-induced glucose uptake
  • data suggest that in the physiological range, E2 is beneficial for insulin sensitivity, whereas hypo- or hyperestrogenism is related to insulin resistance
  • In aging female rats, E2 treatment improves glucose homeostasis mainly through its ability to increase muscle GLUT4 content on the cell membrane
  • It is evident that ERα and ERβ have distinct actions and that much more research is needed to clearly identify the function of each receptor in muscle.
  • E2 prevents accumulation of visceral fat, increases central sensitivity to leptin, increases the expression of insulin receptors in adipocytes, and decreases the lipogenic activity of lipoprotein lipase in adipose tissue
  • In rats, ovariectomy increases body weight, intra-abdominal fat, fasting glucose and insulin levels, and insulin resistance followed by decreased phosphorylation of AMPK and its substrate acetyl-CoA carboxylase in adipose tissue
  • decreased adiponectin, PPARγ coactivator-1α (PGC-1α), and uncoupling protein 2 (UCP2) and increased resistin
  • Men with aromatase deficiency have truncal obesity, elevated blood lipids, and severe insulin resistance
  • Although not all studies are in agreement, polymorphisms of ERα in humans have been associated with risk factors for CVDs
  • Human subcutaneous and visceral adipose tissues express both ERα and ERβ, whereas only ERα mRNA has been identified in brown adipose tissue
  • suggesting that ERα is the main regulator of GLUT4 expression in adipose tissue
  • Nathan Goodyear on 11 Oct 12
     
    very nice article that looks at the balance of ER-alpha/ER-beta and their role in metabolic syndrome.  This article discusses the balance of  these receptors are tissue dependent in their effect.  I like their conclusion: "...but these mechanisms will never be completely understood if they are not considered in the context of a whole system.
Nathan Goodyear

PLOS ONE: N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Prelim... - 0 views

journals.plos.org/...article

Parkinsons Parkinson's disease NAC N-acetylcysteine brain

shared by Nathan Goodyear on 17 Jun 16 - No Cached
  • Nathan Goodyear on 17 Jun 16
     
    pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud.  Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.
Nathan Goodyear

Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia s... - 0 views

www.ncbi.nlm.nih.gov/...11355324

boswellia inflammation IBD ulcerative colitis UC colitis Frankincense

shared by Nathan Goodyear on 20 Feb 17 - No Cached
  • Nathan Goodyear on 20 Feb 17
     
    animal study finds Boswellia reduces inflammation in Inflammatory Bowel Disease.
Nathan Goodyear

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type... - 0 views

edrv.endojournals.org/...599.long

free radicals oxidative stress damage inflammation type II DM alpha lipoic acid alpha-lipoic-acid diabetes

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • In patients with diabetes, LA levels are reduced (48, 74, 103). LA has long been used for the treatment of diabetic neuropathy in Germany
  • evidence indicates that it increases insulin sensitivity in patients with type 2 diabetes
  • LA has been shown to 1) quench free radicals, 2) prevent singlet oxygen-induced DNA damage, 3) exhibit chelating activity, 4) reduce lipid peroxidation, 5) increase intracellular glutathione levels, and 6) prevent glycation of serum albumin (73, 74). LA is able to reduce oxidative stress-mediated NF-κB activation in vitro (74, 108, 109) and in patients with type 2 diabetes
  • ...2 more annotations...
  • Activation of NF-κB can also be blocked by several other thiol-containing antioxidants including N-acetyl-l-cysteine (NAC)
  • Other clinically available antioxidants reported to have antiinflammatory, antioncogenic, and/or antiatherogenic properties that have been shown to block the activation of NF-κB include resveratrol (115, 116), (-)-epicatechin-3-gallate (117), pycnogenol (118), silymarin (119), and curcumin (120)
  • Nathan Goodyear on 02 Aug 12
     
    Great read!  If you want to see how free radicals and oxidative stress contribute to inflammation and disease (DM in this case), read this article.
Nathan Goodyear

Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease - 0 views

www.medicinalnutraceutics.com/...AC%20Alzheimer's%20Disease.pdf

NAC N-acetylcysteine AD Alzheimer's disease Alzheimers inflammation AGE advanced glycation end products

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    NAC shown to improve secondary measures of cognitive function in small study in those with Alzheimer's disease. NAC proves to be a reliable means to reduce free radical induced advanced glycation end productions and resultant inflammation. Also was shown to be well tolerated.
Nathan Goodyear

ingentaconnect Boswellia serrata: An Overall Assessment of In Vitro, Preclinical... - 0 views

www.ingentaconnect.com/...art00001

11-keto-beta-boswellic acid acetyl-11-keto-beta-boswellic acid KBA AKBA inflammation Boswellia acid Frankincense

shared by Nathan Goodyear on 12 Jan 14 - No Cached
  • Nathan Goodyear on 12 Jan 14
     
    Study questions the 5-LOX inhibition as the mechanism of action of Boswellia due to its low absorption.  However, prostaglandin E production was inhibited.  Both have profound antiiflammatory effects and would benefit chronic inflammatory diseases.  
Nathan Goodyear

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to incr... - 0 views

stke.sciencemag.org/...ra106.abstract

nitric oxide NO inflammation SIRT1 sirloins disease aging

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Nitic Oxide (NO) via inflammation deactivates SIRT1 is a common finding in inflammatory diseases of aging, proposes authors of this paper.
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