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Nathan Goodyear

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity... - 0 views

diabetes.diabetesjournals.org/...344.short

sirt1 Resveratrol Diabetes NF-KappaB inflammation

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function
  • central role of NF-κB in cytokine-mediated pancreatic β-cell damage
  • SIRT1 as a possible target to attenuate cytokine-induced β-cell damage.
  • Nathan Goodyear on 18 Mar 11
     
    SIRT1 as possible target to reduce pancreatic inflammation and thus prevent/reduce diabetes;  Oh by the way Resveratrol acts at SIRT1
Nathan Goodyear

Neuroprotective Sirtuin ratio reversed by ApoE4 - 0 views

www.pnas.org/...1314145110.abstract

ApoE4 alzheimer's disease Alzheimer's disease sirtuins SIRT1 resveratrol

shared by Nathan Goodyear on 23 Oct 13 - No Cached
  • Nathan Goodyear on 23 Oct 13
     
    ApoE4 allele is known to increase Alzheimer's disease by 10 fold.  One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio.  This SirT1 is the target of resveratrol in red wine.
Nathan Goodyear

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging - 0 views

www.sciencedirect.com/...S0092867413005941

aging disease SIRT1 inflammation circadian rhythm chronic disease of aging

shared by Nathan Goodyear on 24 Jun 13 - No Cached
  • Nathan Goodyear on 24 Jun 13
     
    SIRT1, known to reduce inflammatory signaling, found to help maintain circadian rhythm.  Loss of the circadian rhythm is know to contribute to chronic disease.  Likewise, SIRT1 has been shown to reduce inflammation, which will reduce disease.  Is this their link?
Nathan Goodyear

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators - 0 views

www.sciencemag.org/...1216

resveratrol health SIRT1

shared by Nathan Goodyear on 11 Mar 13 - No Cached
  • Nathan Goodyear on 11 Mar 13
     
    science validates the health benefits of resveratrol.  The benefit is through SIRT1 activation.
Nathan Goodyear

Mechanism of Human SIRT1 Activation by Resveratrol - 0 views

www.jbc.org/...17187.short

Resveratrol SIRT1

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension
  • resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway.
  • Nathan Goodyear on 18 Mar 11
     
    Resveratrol potentially increases life span through SIRT1 activation
Nathan Goodyear

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to incr... - 0 views

stke.sciencemag.org/...ra106.abstract

nitric oxide NO inflammation SIRT1 sirloins disease aging

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Nitic Oxide (NO) via inflammation deactivates SIRT1 is a common finding in inflammatory diseases of aging, proposes authors of this paper.
Nathan Goodyear

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communica... - 0 views

www.cell.com/...S0092-8674(13)01521-3

NAD mitochondria disease aging sirloins SIRT SIRT1 HIF-1alpha

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    NAD found to slow mitochondrial decline associated with aging.  SIRT1 is involved; interesting of note is the inverse association with HIF-1alpha
Nathan Goodyear

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects aga... - 0 views

www.ncbi.nlm.nih.gov/...PMC3616313

NAD nicotinamide riboside metabolism obesity SIRT sirtuins

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    nicotinamide riboside shown to offset the negative metabolic effects of American diet induced obesity.  NAD also increased SIRT1 and SIRT3 activity
Nathan Goodyear

Modulation of NF-[kappa]B-dependent transcription and cell survival by the SIRT1 deacet... - 0 views

www.nature.com/...7600244a.html

resveratrol inflammation

shared by Nathan Goodyear on 18 Mar 11 - No Cached
  • Treatment of cells with resveratrol, a small-molecule agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region, an effect that correlates with a loss of NF-B-regulated gene expression
  • Nathan Goodyear on 18 Mar 11
     
    resveratrol decreases NF-kappa Beta expression and thus reduces inflammation
Nathan Goodyear

THE NEUROPROTECTIVE PROPERTIES OF CALORIE RESTRICTION, THE KETOGENIC DIET, AND KETONE B... - 0 views

www.ncbi.nlm.nih.gov/...PMC2649682

calorie restriction ketogenic diet NF-KappaB BDNF neuroprotection SIRT1 mitochondria glutamate excitotoxicity inflammation antioxidants

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Fantastic read on the biochemical benefits of calorie restriction and a ketogenic diet.
Nathan Goodyear

Is Timing Everything? New Insights into Why the Effect of Estrogen Therapy on Memory Mi... - 0 views

endo.endojournals.org/...2570.full

estrogen therapy memory hormone therapy HRT BHRT Estradiol neurology brain women hormone hormones

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Women who have an oophorectomy before the normal age at menopause show an increased risk for cognitive impairment or dementia later in life unless they are treated with estrogen until the normal age at menopause
  • SIRT1 has been implicated in the disruption of mitochondrial bioenergenetics in Alzheimer's disease and mild cognitive impairment
  • the increase in dementia observed with CEE/MPA rather than CEE alone suggests potential deleterious effects of MPA on brain function in older women
  • ...1 more annotation...
  • SIRT 1 as a potential mediator of the impact of E2
  • Nathan Goodyear on 06 Aug 13
     
    Early estrogen therapy in perimenopause and early menopause, with Estradiol, provides more health benefits than later therapy.  This article looked at Estrogen's effects on a woman's brain.  This likely has its origins in the change in estrogen receptors. The signal is not changing, but the reception of that signal is.  How else can one explain a different response to the same hormone dosage?
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