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Nathan Goodyear

Age-Related White Matter Changes - 0 views

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    Good review of White matter changes associated with aging and associated risks and treatments.
Nathan Goodyear

White matter dementia - 0 views

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    white matter dimentia
Nathan Goodyear

Mediterranean diet, cognitive function, and dementia: a systematic review. - PubMed - NCBI - 0 views

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    review finds Mediterranean diet may slow cognitive decline and decrease risk of Alzheimer's disease.
Nathan Goodyear

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence - 0 views

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    review finds Mediterranean diet associated with improved cognitive function and possible delay in cognitive decline.
Nathan Goodyear

Association Between Androgen Deprivation Therapy and Risk of Dementia | Dementia and Co... - 0 views

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    ADT for prostate cancer doubles risk of dementia in men.
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.po... - 0 views

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    Another meta-analysis, this time of 20 studies, finds benefit of huperzine A in the treatment of Alzheimer's disease.
Nathan Goodyear

Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis - 0 views

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    Good review of the data on Huperzine A and Alzheimer's dementia.
Nathan Goodyear

Multicentre study of l-alpha-glyceryl-ph... [Drugs Aging. 1993 Mar-Apr] - PubMed - NCBI - 0 views

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    alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.
Nathan Goodyear

http://www.update-software.com/BCP/WileyPDF/EN/CD007365.pdf - 0 views

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    meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.  

    There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  
Nathan Goodyear

Treating senile dementia with traditional Chinese medicine - 0 views

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    Great review of the literature supporting herbal therapies in the treatment of dementia.
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

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    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

PLOS ONE: Healthy Lifestyles Reduce the Incidence of Chronic Diseases and Dementia: Evi... - 0 views

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    Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle.  Translation:  many don't want health even when presented with evidence of its benefits and the means to achieve it.  

    This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.
Nathan Goodyear

Serum Folate, Homocysteine, Brain Atrophy, and Auto-CM System: The Treviso Dementia (TR... - 0 views

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    Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Nathan Goodyear

Glucose Levels and Risk of Dementia - NEJM - 0 views

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    Even in the non-diabetic, an elevated glucose level is association with an increase risk of Alzheimer's.
Nathan Goodyear

Alcohol intake and risk of dementia. [J Am Geriatr Soc. 2004] - PubMed - NCBI - 0 views

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    Moderate wine intake daily associated with a lower risk of Alzheimer's disease in the elderly.  But, only in those without the APOE epsilon-4 allele.
Nathan Goodyear

Lifelong Estrogen Exposure and Memory in Older Postmenopausal Women - Journal of Alzhei... - 0 views

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    Study finds suggestion of cognitive protection by enduring estrogen exposure.  Interesting, that estrogen seems to protect against cognitive decline in women, yet increases cognitive decline in men.
Nathan Goodyear

Dietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older ... - 0 views

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    Study in people with Alzheimer's dementia, finds that those with dementia have lower levels of the antioxidants vitamin C and beta-carotene.
Nathan Goodyear

Cognitive improvement in mild to moderate Alzheime... [Clin Ther. 2003] - PubMed - NCBI - 0 views

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    alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.
Nathan Goodyear

Alpha lipoic appears to be an effective neuroprotective agent in - 0 views

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    Alpha lipoic acid at relatively low oral dosing found to slow progression of moderate dementia as compared to cholinesterase inhibitors.
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