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Nathan Goodyear

http://www.update-software.com/BCP/WileyPDF/EN/CD007365.pdf - 0 views

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    meta-analysis found no high level of evidence to support Huperzine A in the treatment of vascular dementia.  The conclusion sounds scientifically sound, but when you look at the studies included: this is a meta-analysis of 1 of Huperzine A and vascular dementia.  This one study was of 14 participants only and they found improvement in daily functioning.  

    There are a lot of animal studies that point out benefits of huperzine A and even the mechanisms of action,  but human studies are lacking.  That is a better conclusion.  
Nathan Goodyear

Treating senile dementia with traditional Chinese medicine - 0 views

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    Great review of the literature supporting herbal therapies in the treatment of dementia.
Nathan Goodyear

Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial F... - 0 views

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    Huperzine A, a natural acetylcholinesterase inhibitor, provides neuroprotection through increase mitochondrial function and decrease in accumulated amyloid Beta protein.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

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    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

PLOS ONE: Healthy Lifestyles Reduce the Incidence of Chronic Diseases and Dementia: Evi... - 0 views

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    Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle.  Translation:  many don't want health even when presented with evidence of its benefits and the means to achieve it.  

    This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.
Nathan Goodyear

Serum Folate, Homocysteine, Brain Atrophy, and Auto-CM System: The Treviso Dementia (TR... - 0 views

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    Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Nathan Goodyear

Glucose Levels and Risk of Dementia - NEJM - 0 views

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    Even in the non-diabetic, an elevated glucose level is association with an increase risk of Alzheimer's.
Nathan Goodyear

Alcohol intake and risk of dementia. [J Am Geriatr Soc. 2004] - PubMed - NCBI - 0 views

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    Moderate wine intake daily associated with a lower risk of Alzheimer's disease in the elderly.  But, only in those without the APOE epsilon-4 allele.
Nathan Goodyear

Lifelong Estrogen Exposure and Memory in Older Postmenopausal Women - Journal of Alzhei... - 0 views

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    Study finds suggestion of cognitive protection by enduring estrogen exposure.  Interesting, that estrogen seems to protect against cognitive decline in women, yet increases cognitive decline in men.
Nathan Goodyear

Dietary Antioxidants and Dementia in a Population-Based Case-Control Study among Older ... - 0 views

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    Study in people with Alzheimer's dementia, finds that those with dementia have lower levels of the antioxidants vitamin C and beta-carotene.
Nathan Goodyear

Cognitive improvement in mild to moderate Alzheime... [Clin Ther. 2003] - PubMed - NCBI - 0 views

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    alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.
Nathan Goodyear

Alpha lipoic appears to be an effective neuroprotective agent in - 0 views

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    Alpha lipoic acid at relatively low oral dosing found to slow progression of moderate dementia as compared to cholinesterase inhibitors.
Nathan Goodyear

Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms o... - 0 views

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    Small case study of 3 finds significant improvement in Alzheimer's with Turmeric.
Nathan Goodyear

JAMA Network | JAMA | Estrogen Plus Progestin and the Incidence of Dementia a... - 0 views

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    Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.
Nathan Goodyear

JAMA Network | JAMA | Conjugated Equine Estrogens and Incidence of Probable D... - 0 views

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    This was the WHI review of data as it pertains to dementia and cognitive decline in women.  The take home here is that the data provides little evidence for premarin with or without medroxyprogesterone acetate in > 65 for prevention of dementia.  However, this is in women > 65 and studies show that younger women do indeed receive benefit, especially in those with early ovary removal.  Another point here, MPA (medroxyprogesterone acetate) increases cognitive decline.  Just don't take MPA, it is a bad drug all the way around!
Nathan Goodyear

Increased risk of cognitive impairment or dementia in women who underwent oophorectomy ... - 0 views

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    Untold risk of early ovary removal appears to be cognitive decline and increased risk of dementia.  The earlier the age of removal, the more the increased risk of cognitive decline.  
Nathan Goodyear

Sex hormones and cognitive decline ... [Psychoneuroendocrinology. 2009] - PubMed - NCBI - 0 views

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    increased estradiol and estrone levels in men associated with cognitive decline.  This was distinct from age, CVD, and APOE genotype.  This points to a clear association between increased aromatase activity and inflammation that contributes to cognitive decline in men.
Nathan Goodyear

The Role of Peripheral Inflammatory Markers in Dementia and Alzheimer's Disease: A Meta... - 0 views

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    CRP and IL-6 are found to be associated with an increased risk of dementia.
Nathan Goodyear

Higher Free Thyroxine Levels Predict Increased Incidence of Dementia in Older Men: The ... - 0 views

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    what a silly study!  They look at free T4, the weakest thyroid hormone and found high levels to be associated with dementia.  However, they failed to assess free T3, the most biologically active, and reverse T3, inactive.  This study was like they intentionally blinded themselves of the body's physiology to study dementia.  This is the problem with a lot of research today: they have forgotten their foundation.

    Many older adults struggle with poor free T4 to free T3 conversion and high reverse T3 conversion.  So, without knowing what these clients were doing in these pathways makes their conclusion obsolete.
Nathan Goodyear

Neuroprotective lifestyles and the aging brain - 0 views

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    exercise limits brain atrophy in the elderly.  Exercise provides neuroprotection.
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