Skip to main content

Home/ Dr. Goodyear/ Group items tagged acetylcholine

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Effect of supplementation of vi... [J Nutr Sci Vitaminol (Tokyo). 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11814146

vitamin C ascorbic acid Alzheimer's disease acetylcholine memory

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    vitamin C inhibits acetylcholinesterase.  This will increase acetylcholine and thus can play a role in Alzheimer's disease.  People with Alzheimers disease have low levels of Vitamin C.  Vitamin C shown to improve memory in Alzheimer's mouse model.
Nathan Goodyear

Acetyl-L-carnitine treatment increases choline ace... [Brain Res. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8137174

Acetyl-L-carnitine carnitine brain acetylcholine nerve growth factor

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Rat study, but acetyl-L-carnitine shown to increase nerve growth factor.  In addition, it increased acetylcholine activity.
Nathan Goodyear

American Journal of Hypertension - Abstract of article: Superoxide Scavenging Effects o... - 0 views

www.nature.com/...ajh2005179a.html

IV iintravenous vitamin C NAC superoxide scavenger essential hypertension

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C therapy shown to improved the response of blood pressure to acetylcholine and nitroprusside in those patients with essential hypertension.  This effect was not found in NAC.  Vitamin C acts as a superoxide scavenger and glutathione recycler.
Nathan Goodyear

Acta Pharmacologica Sinica - Progress in studies of huperzine A, a natural cholinestera... - 0 views

www.nature.com/...aps20061a.html

Huperzine-A Huperzine Alzheimer's disease brain NMDA organophosphate organophosphates

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    This study found that Huperzine A improved memory deficits in elderly and those with Alzheimer's disease.  Huperzine A is an acetylcholinisterase inhibitor, thereby increasing the neurotransmitter acetylcholine.  Huperzine A has also been shown to be neuroprotective through its antagonistic action with the NMDA receptors. Huperzine A has been shown to be protective from organophosphate toxicity.
Nathan Goodyear

Efficacy and safety of natural acetylcholine... [J Neural Transm. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19221692

Huperzine A Huperzine-A cognition Alzheimer's disease

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Huperzine A shown to improve cognition in Alzheimer's disease.  This was a meta-analysis.
Nathan Goodyear

The implication of neuroactive steroids in Tourette syndrome pathogenesis: a ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3849218

tourette's syndrome hormones 5-alpha reductase

shared by Nathan Goodyear on 08 Dec 15 - No Cached
  • The typical onset of TS occurs at 6–7 years of age and is characterized by the appearance of simple, recurrent motor tics, followed by the manifestation of phonic tics after several months [12]. In most children, TS symptoms undergo a progressive exacerbation, which reaches its zenith at the beginning of puberty (11–12 years of age), and is then followed by a gradual remission in the majority of patients
  • 30–40% of TS-affected children retain their symptoms in adulthood
  • Multiple neurotransmitters have been implicated in TS, including dopamine (DA), serotonin, norepinephrine, acetylcholine, glutamate and γ-amino-butyric acid (GABA)
  • ...11 more annotations...
  • ample evidence supports the involvement of DAergic dysfunctions in TS
  • male gender is a major risk factor for TS (with a male:female prevalence ratio estimated at ~4:1)
  • the typical age of onset coincides with adrenarche (6–7 years old); symptoms increase in severity until the beginning of puberty (12 years old) and then undergo a spontaneous amelioration, which becomes apparent with the end of puberty (at 18–19 years of age)
  • TS is diagnosed later in females than males
  • female gender may predict greater tic severity in adulthood
  • a number of clinical observations showed that tics in TS patients could be exacerbated by anabolic androgens
  • steroidogenic enzymes and androgen receptors may serve as putative therapeutic targets for this disorder
  • Unlike males, tic severity is typically increased after puberty in females
  • 26% of females were found to experience exacerbation of tics in the estrogenic phase of the menstrual cycle, and this phenomenon was found to be correlated with increased tic severity at menarche
  • biochemical hallmark of adrenarche is the acquisition of 17,20 lyase activity by cytochrome P450 C17 (CYP17A1)
  • increased synthesis of dehydroepiandrosterone (DHEA) and androstenedione, which leads to the growth of axillary and pubic hair as well as enhancement in the oiliness of the skin
  • Nathan Goodyear on 08 Dec 15
     
    interesting read on hormones and tourette's.. Proposed that 5 alpha reductase activity is involved in worsening of tics.  This makes sense as Testosterone in men with low T is known to increase dopamine and dopaminergic dysfunction is known to play a role in tourette's;  the clinical presentation of girls vs boys is very different.  The authors of this article propose that 5 alpha reductase activity controls a back door method where by progesterone is converted to androgens.
Nathan Goodyear

Opioid-induced nausea and vomiting - Smith - Annals of Palliative Medicine - 0 views

apm.amegroups.com/...1264

nausea

shared by Nathan Goodyear on 14 Aug 18 - No Cached
  • Some of the “emetogenic” receptors that have been proposed are dopamine-2 (D2), histamine-1 (H1), DOR, 5-hydroxytryptamine (serotonin) (5-HT3), acetylcholine (ACh), neurokinin-1 (NK-1), and cannabinoid receptor-1 (CB1)
  • Olanzapine decreased morphine-induced nausea and vomiting in a dose-dependent manner.
  • Nathan Goodyear on 14 Aug 18
     
    Good review of meds for nausea.
Nathan Goodyear

Alzheimer's Disease Clinical and Research Update for Health Care Practitioners - 0 views

www.ncbi.nlm.nih.gov/...PMC3776389

Alzheimer's disease cognition memory Alzheimers brain brain health alpha-GPC phosphatidyl serine Huperzine A choline

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Alpha GPC, phosphatidylserine, Huperzine A, and choline show promise as nutraceutical agents for enhancing cognitive performance and slowing cognitive decline
  • Alpha GPC, also known as L-Alpha Glycerylphosphorylcholine, a naturally occurring form of choline, acts as a parasympathomimetic acetylcholine precursor and has shown promise in improving cognitive symptoms related to AD, vascular dementia, and multi-infarct dementia
  • Phosphatidylserine is a widely abundant anionic phospholipid in the human body and has been shown to improve age-related cognitive changes
  • ...2 more annotations...
  • Huperzine A (a natural cholinesterase inhibitor) has been linked to improved memory performance in elderly people with benign forgetfulness, as well as patients with AD and vascular dementia
  • Cholinesterase inhibitors have been shown to have neuroprotective properties in patients with mild [37] as well as moderate-to-advanced AD
  • Nathan Goodyear on 26 Sep 17
     
    good review of treatment for Alzheimer's, both prescription and natural.
1 - 8 of 8
Showing 20▼ items per page