Group items tagged

ibuprofen provided no reduction in muscle damage/soreness in 29 ultra marathoners.  However, LPS, CRP, IL-6, IL-10, IL-8, IL-1ra, GSF, MCP-1, and MIP-1beta were increased in the ibuprofen group.  TNF-alpha was unaffected.

EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis.  Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.

Large Moscow study found testosterone replacement to be associated with a reduction in the inflammatory markers TNF-alpha, IL-1beta, IL-6, and CRP.

salivary biomarker IL-1beta found to be associated with diabetes risk.

Great review of all the known components in the inflammation, insulin resistance link

Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.   And PSA?  No mention of it here.   This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?   This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

Great article.  Really shows the depth of the androgens and androgen metabolites in diabetes and diabetic complications.  In this study, DHT and its metabolis 3-alpha androstanediol were shown to reduce inflammation and pain associated with diabetic neuropathy.  Significant reduction in inflammation signaling (IL-1beta, TNF-alpha) was seen as was potential neurodegenerative processes (glutamate release and astrocyte immunoreactivity).

Sometimes I think medicine has lost its mind.  Or at least, it is not thinking things through.  To give IV estrogen to decrease Testosteorne in men with prostate cancer is devoid of the pathophysiology of prostate cancer and cardiovascular disease in men.  Elevated Estradiol in men increases CRP, IL-1beta, and TNF-alpha to name a few cytokines.  The proported purpose of the IV estrogen is to prevent the cardiovascular complications associated with ADT.  Yet, elevated aromatase activity and low T in men are both shown to be associated with increased CVD in men.

Mouse model study finds that radiation promotes increase IL-1beta, CTC, and lung metastasis.

Ultra endurance athletic events associated with significant increase in systemic inflammation due to damaged gut.

Study finds spore probiotic for 30 days reduced LPS endotoxin by 42%, while the placebo group found a 36% increase.  As a result, and to no surprise, there was a significant drop in IL-beta.  Also, in the spore probiotic group, there was a 24% reduction in triglycerides.

Progesterone useful in inflammation reduction in Traumatic Brain Injuries.  This applies to both sexes.