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Nathan Goodyear

Prevalence of low testosterone levels... [J Family Community Med. 2013] - PubMed - NCBI - 0 views

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    This study follows others: Diabetes associated with low Total Testosterone.  The question is whether this is a cause and effect or merely an association?

    This study also found age, income, BMI, and diabetic neuropathy as risk for low Testosterone.
Nathan Goodyear

Diabetic neuropathic pain: a role for testosterone metabolites - 0 views

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    Great article.  Really shows the depth of the androgens and androgen metabolites in diabetes and diabetic complications.  In this study, DHT and its metabolis 3-alpha androstanediol were shown to reduce inflammation and pain associated with diabetic neuropathy.  Significant reduction in inflammation signaling (IL-1beta, TNF-alpha) was seen as was potential neurodegenerative processes (glutamate release and astrocyte immunoreactivity).
Nathan Goodyear

Alpha-lipoic acid in the treatm... [Exp Clin Endocrinol Diabetes. 1999] - PubMed - NCBI - 0 views

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    alpha lipoic acid shown to reduce diabetic neuropathy in this review of 15 clinical trials.  The trials included both IV and oral administration of alpha lipoic acid.  Both routes of administration revealed positive reduction of neuropathic symptoms.
Nathan Goodyear

Low free testosterone levels are associated wi... [Diabetes Care. 2011] - PubMed - NCBI - 0 views

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    low free Testosterone shown to increase mortality risk in postmenopausal, diabetic women.  No association was found with total testosterone or SHBG
Nathan Goodyear

Dehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus ... - 0 views

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    Fascinating article: DHEA found to decrease NF-KappaB activity in the hippocampus region of the brain.  This has implications in protecting the brain.  In this study, the implication was reduction in inflammation in the hippocampus region in diabetic rat model.
Nathan Goodyear

Arch Intern Med -- Cardiovascular Risk Prediction in Diabetic Men and Women Using Hemog... - 0 views

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    HbA1C predictive of cardiovascular disease risk
Nathan Goodyear

Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet... - 0 views

  • L-arginine supplementation further decreased FM (P < 0.05) and waist circumference (P < 0.0001), preserving FFM (P < 0.03), and improved mean daily glucose profiles (P < 0.0001) and fructosamine (P < 0.03). Moreover, change in area under the curve of cGMP (second messenger of nitric oxide; P < 0.001), superoxide dismutase (index of antioxidant capacity; P < 0.01), and adiponectin levels (P < 0.02) increased, whereas basal endothelin-1 levels (P < 0.01) and leptin-to-adiponectin ratio (P < 0.05) decreased in the L-arginine group.
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    L-Arginine helps to preserve muscle, while increase fat loss.  This will help to prevent fat rebound in weight loss programs.  Additionally, insulin resistance improved.
Nathan Goodyear

Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy - 0 views

  • Oral treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in patients with DSP
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    alpha Lipoic Acid improves Diabetic Neuropathy
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