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Nathan Goodyear

Association between endogenous sex steroid hormones and inflammatory biomarkers in US men - 0 views

www.ncbi.nlm.nih.gov/...PMC3812341

low Testosterone Estrogen Estradiol low T Testosterone hormone hormones CRP inflammation SHBG WBC men male

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • modest statistically significant inverse associations for total and calculated free testosterone, and modest positive associations for total and calculated free estradiol with CRP concentration
  • Estradiol concentrations were also weakly positively associated with WBC count
  • SHBG was weakly inversely associated with WBC
  • ...21 more annotations...
  • An association between testosterone and WBC count was not observed
  • These findings are consistent with the hypothesis that in men higher androgen concentration is anti-inflammatory, and higher estrogen concentration is pro-inflammatory.
  • the probability of elevated CRP concentrations (≥ 3 mg/L) decreased with higher total and calculated free testosterone concentrations, while the probability increased with higher total and calculated free estradiol concentrations
  • there is ample evidence supporting the immunosuppressive effect of androgens
  • The incidence of autoimmune diseases is higher in androgen-deficient men
  • Studies have shown that the induction of hypogonadism in older men is followed by a significant increase in IL-6 concentrations (Khosla et al. 2002), a potent stimulator of inflammation, and that activation of the androgen receptor exerts a direct anti-inflammatory effect
  • It has been suggested that the mechanisms for the immunosuppressive effect of androgens could be either a direct effect on the expression of inflammatory genes (Bellido et al. 1995; Asirvatham et al. 2006), or an indirect effect through inhibition of nuclear factor-kB activation
  • Estradiol is the major biologically active estrogen, and about 80% is formed in adult men from the aromatization of testosterone primarily in the adipose tissue
  • estrogen can stimulate the transcription factor C/EBP-β, which is involved in CRP transcription
  • Most prior cross-sectional studies have observed inverse associations between androgen concentrations and inflammatory biomarkers
  • A recent study in Chinese men showed that lower concentrations of total and calculated free testosterone were associated with higher CRP concentration
  • Data from the Boston Area Community Health Survey also reported inverse associations between testosterone and CRP concentrations
  • Total testosterone was inversely associated with WBC count (Tang et al. 2007; Schneider et al. 2009; Brand et al. 2012), but calculated free testosterone was not associated with WBC
  • The first trial found a decrease in CRP, interleukin-1β (IL-1β), and tumor necrosis factor-α (TNFα) but no changes in IL-6 and IL-10 concentrations between the active treatment and placebo arms
  • the majority of studies in the literature have not observed statistically significant associations between estradiol and inflammatory biomarkers in men, although several of them observed point estimates in the positive direction
  • total testosterone and estradiol compete for binding to SHBG, and seem to have opposite effects on the concentration of inflammatory biomarkers
  • A small randomized controlled trial of estrogen replacement therapy in prostate cancer patients showed an increase in CRP in the active treatment group versus the comparator group
  • Obese men are known to have lower androgen concentrations compared to their normal-weight counterparts
  • The strongest suggestion of an interaction was the inverse association between androstanediol glucuronide and CRP concentrations in obese participants, while the association was positive in the non-obese
  • A recent Chinese cross-sectional study observed stronger inverse associations between total testosterone and CRP concentrations in individuals with a BMI of 27.5 kg/m2 or greater
  • our results suggest that total and calculated free testosterone are modestly inversely associated with CRP concentrations, and that total and calculated free estradiol are modestly positively associated with CRP and WBC
  • Nathan Goodyear on 28 Apr 15
     
    Study results suggest that higher Testosterone and lower Estrogen levels provide anti-inflammatory effects in men.  The inflammatory biomarker assessed here was CRP.  Low total and calculated free Testosterone was associated with an increase in CRP.  In contrast, total and free Estrogen was associated with an increase in CRP.  Estradiol increased WBC count and SHBG was inversely related to WBC count in this study.
Nathan Goodyear

Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignan... - 0 views

www.ncbi.nlm.nih.gov/...PMC3665464

TK-1 TK-1 cancer thymidine kinase 1 cancer biomarker

shared by Nathan Goodyear on 04 Mar 15 - No Cached
  • Thymidine kinase 1 (TK1) is a proliferation biomarker
  • Nuclear TK1 expression in early grade CIN predicts risk for progression to malignancy
  • Nuclear TK1 expression is also a prognostic factor for treatment outcome
  • ...9 more annotations...
  • TK1 LI was found to be a more reliable prognostic marker for 5-year survival than pathological stages, FIGO stages and Ki-67,
  • nuclear TK1 expression is a reliable prognostic factor in CIN patients, a group of cervical lesion patients that respond positively to treatment
  • nuclear TK1 expression is correlated with advanced stage of invasive cervical carcinomas
  • a low TK1 LI can help to identify with a better survival
  • low TK1 expression in the tumors in these patients might indicate that these tumors have a lower proliferation rate
  • TK1 is a key kinase in the one-step salvage pathway by which thymidine is introduced into DNA via the salvage pathway
  • TK1 participates in DNA synthesis and is therefore closely related to the S-phase of the cell cycle, and is correlated with proliferation
  • TK1 intensity (TK1 synthesis rate) increases from CIN grade I to CIN grade III, but does not further increase in invasive cervical carcinomas.
  • TK1 intensity seems to be a prognostic factor particularly when pre-malignant cervical lesions progress to malignancy
  • Nathan Goodyear on 04 Mar 15
     
    TK-1 is a proliferation biomarker of DNA repair. TK-1 is a nuclear biomarker of cancer prognosis, survival, recurrence and predicts risk of progression of pre-malignant disease.
Nathan Goodyear

Evaluation of FLT-PET-CT as an imaging biomarker of proliferation in primary breast can... - 0 views

www.nature.com/...bjc2014207

PET scan PET_CT scan cancer breast

shared by Nathan Goodyear on 19 Mar 18 - No Cached
  • We have demonstrated that the majority of patients have a sizeable reduction in SUVmax from a single cycle of NAC with a mean change of −32.3%
  • This study, however, failed to show any predictive markers of response after one cycle of chemotherapy
  • These data therefore suggest that the main utility of FLT-PET as an imaging biomarker in early breast cancer is pre-chemotherapy, as a marker of proliferation, rather than in predicting pathological response after chemotherapy
  • ...2 more annotations...
  • In terms of the histological proliferation biomarker Ki-67, we have shown a good correlation with FLT-PET pre-chemotherapy. The best predictive marker of response in terms of pCR was baseline Ki-67
  • Our study has shown that baseline Ki-67 and FLT SUVmax is well correlated in keeping with FLT-PETs status as a proliferation biomarker, although Ki-67 had a better predictive ability in terms of pathological outcome
  • Nathan Goodyear on 19 Mar 18
     
    PET CT scan shown to be useful as a proliferation biomarker pre-chemo in breast cancer.
Nathan Goodyear

Role of Pancreatic Cancer-derived Exosomes in Salivary Biomarker Development - 0 views

www.jbc.org/26888

saliva testing salivary pancreatic cancer

shared by Nathan Goodyear on 16 Oct 13 - No Cached
  • Nathan Goodyear on 16 Oct 13
     
    Saliva is proving to be an exciting medium for functional testing.  Recently, studies have found saliva as a great medium to evaluate for cancer biomarkers.  This study find pancreatic cancer biomarkers in saliva.
Nathan Goodyear

Inflammatory biomarkers in saliva: assess... [J Clin Periodontol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22420648

saliva salivary inflammatory markers biomarkers IL-beta diabetes DM

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    salivary biomarker IL-1beta found to be associated with diabetes risk.
Nathan Goodyear

Salivary biomarkers in psychobiological medicine - 0 views

www.ncbi.nlm.nih.gov/...PMC1891707

saliva salivary testing analysis inflammatory cytokines biomarker

shared by Nathan Goodyear on 30 May 12 - No Cached
  • Nathan Goodyear on 30 May 12
     
    saliva is the future of biomarker testing, such as inflammatory cytokines, neuro-endocrine evaluation...
Nathan Goodyear

Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Mu... - 0 views

cebp.aacrjournals.org/...102.full

cancer biomarkers inflammation inflammatory cytokines cytokines

shared by Nathan Goodyear on 22 Sep 14 - No Cached
  • Nathan Goodyear on 22 Sep 14
     
    Article looks at proposed 25 biomarkers to screen for Head and Neck squamous cancer.  Most of these could be used for all cancers as they are inflammatory cytokines.
Nathan Goodyear

The use of fecal calprotectin and la... [Acta Gastroenterol Belg. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24261027

calprotectin lactoferrin inflammation IBD IBS inflammatory bowel disease

shared by Nathan Goodyear on 06 Jan 14 - No Cached
  • Nathan Goodyear on 06 Jan 14
     
    Useful biomarkers: calprotectin and lactoferrin used to follow GI inflammation.  Calprotectin is useful to follow inactive/active IBD.  It also has been show to predict recurrence and can aid in differentiation between IBD and IBS.  Lactoferrin appears to be a biomarker more useful in GI inflammation.
Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

eurheartj.oxfordjournals.org/...998

endurance athletes training heart health injury

shared by Nathan Goodyear on 09 Jan 15 - No Cached
  • In a cohort of well-trained athletes, we demonstrated that intense endurance exercise causes an acute reduction in RV function that increases with race duration and correlates with increases in biomarkers of myocardial injury
  • no relationship between LV function and biomarker levels
  • focal gadolinium enhancement and increased RV remodelling were more prevalent in those athletes with a longer history of competitive sport, suggesting that repetitive ultra-endurance exercise may lead to more extensive RV change and possible myocardial fibrosis
  • ...22 more annotations...
  • he cardiac impact of both acute and cumulative exercise is greatest on the RV.
  • Greater reductions in RV function occurred in those athletes competing for a longer duration, suggesting that the heart has a finite capacity to maintain the increased work demands of exercise
  • cardiac injury is greatest in the least trained
  • Previous investigators have documented reductions in RV function in less trained subjects over the marathon distance
  • We enrolled elite and subelite athletes and found a significant association between fitness (VO2max) and the reduction in post-race RVEF
  • Even after many years of detraining, cardiac dilation may not completely regress in elite athletes
  • The focus on well-trained athletes may be of particular relevance, given that they perform exercise of highest intensity and duration most frequently, and, thus, may be at a greater risk of cumulative injury.
  • The lack of correlation between increases in troponin and changes in LV function seen in this study has been previously interpreted as evidence that post-exercise elevations in cardiac biomarkers are benign.
  • a significant correlation between changes in RVEF and post-race biomarker levels and this relationship was even stronger in the athletes who completed the race of longest duration, the ultra-triathlon
  • The correlations with RVEF, but not LVEF, provide further evidence of the differential effects of intense exercise on RV and LV function
  • BNP release during intense exercise is associated with greater relative increases in RV systolic pressures, but not LV pressures
  • BNP may provide a measure of both acute RV load and the resultant fatigue which occurs when this load is sustained
  • It has been demonstrated that ventricular load increases with exercise intensity and is greater for the RV than the LV,29 thus potentially explaining why the RV is more susceptible to fatigue after prolonged exercise.
  • This study demonstrates, for the first time, an association between endurance exercise of increasing duration and structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes
  • Functional abnormalities were confined to the RV and were largely reversible 1 week following the event
  • there remained a significant minority of athletes in whom there was evidence of myocardial fibrosis in the interventricular septum
  • RV abnormalities may be acquired through cumulative bouts of intense exercise and provides direction for prospective investigations aimed at elucidating whether extreme exercise may promote arrhythmias in some athletes.
  • the acute injury and chronic remodelling of the myocardium both disproportionately affect the RV and it remains possible that the two are linked.
  • focal DGE was confined to the interventricular septum and commonly at the site of RV attachment
  • emerging evidence that intense endurance exercise may be associated with an excess in arrhythmic disorders, the mechanisms for which remain unexplained
  • RVEF (and not LVEF) was reduced in athletes with complex ventricular arrhythmias when compared with healthy athletes and non-athletes without arrhythmias
  • it is premature to conclude that these changes may represent a proarrhythmic substrate
  • Nathan Goodyear on 09 Jan 15
     
    Study finds endurance racing results in reduce Right ventricle ejection fraction even in elite athletes.  This post-race RVEF reduction is associated with VO2max.
Nathan Goodyear

The Association between Premature Coronary Art... [Arch Iran Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25065277

low T Testosterone low T low Testosterone free Testosterone Total Testosterone CAD coronary artery disease atherosclerosis heart disease men male hormone hormones health

shared by Nathan Goodyear on 30 Jul 14 - No Cached
  • Nathan Goodyear on 30 Jul 14
     
    Low free and Total Testosterone levels found to be associated with premature CAD in men.  Some confounders were present, which they tried to account for--this should leave some healthy questioning of this study results.  That being said, this is not the first time low T has been found to be associated with CAD in men.  This study found a statistical significant association with Free and Total Testosterone levels in young men.  Another point to consider is the Low T a cause or a biomarker and an effect of poor/declining health?  I would so more to the biomarker point.
Nathan Goodyear

Low testosterone is associated with poor health status in men with ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25704864

low T Testosterone low Testosterone HIV fT3 poor health men male hormones hormone

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Lower Testosterone levels are found in men with more advanced HIV.  This relationship is bidirectional.  This decreased biomarker is likely more a biomarker of poor health than one of a direct relationship.  As in the fT3 is lower in hypogonadal men versus eugonadal men.  This points to the significant problems in the way Testosterone is thought of and used in therapy for men today.  For many men, low T is the effect and not the cause.
Nathan Goodyear

Anemia as an independent prognostic factor for survival in patients with cancer - Caro ... - 0 views

onlinelibrary.wiley.com/...full

anemia cancer

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is common in cancer patients,1, 20 and it has been associated with lower survival
  • median survival was reduced by 20–43%
  • Nathan Goodyear on 30 Mar 15
     
    anemia is a poor prognostic biomarker in cancer.  But is it simply a biomarker of more advanced disease and thus merely the result of poor health?
Nathan Goodyear

Galectin-3 as an Oncological Biomarker | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...lectin-3-oncological-biomarker

cancer galectin-3

shared by Nathan Goodyear on 02 Feb 21 - No Cached
  • Nathan Goodyear on 02 Feb 21
     
    Another helpful cancer biomarker to assess/follow.
Nathan Goodyear

IL-1α and IL-1β Levels in Blood Serum and Saliva ... [Endocr Res. 2012] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...22894561

biomarkers interleukins IL-1Beta IL-1alpha saliva salivary inflammation

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    Interleukins IL-1alpha and IL-1beta in saliva found to not be signifcantly different than serum.  Point: saliva is a good medium to evaluate many other biomarkers, inflammatory markers in this case.
Nathan Goodyear

Preventing Chronic Disease | Plasma Vitamin D and Biomarkers of Cardiometabolic Disease... - 0 views

www.cdc.gov/...12_0230.htm

vitamin D CRP cardiovascular disease CVD vitamin D

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Higher vitamin D levels associated with lower cardio biomarkers: insulin, insulin resistance, triglycerides, TC, LDL and TC:HDL.  Not found to be associated: glucose, apoliporotein A1 and B, CRP, fibrinogen, and homocysteine.
Nathan Goodyear

A Vitamin B-12 Supplement of 500 μg/d for Eight Weeks Does Not Normalize Urin... - 0 views

jn.nutrition.org/...142.abstract

vitamin B12 B12 vitamin vitamins

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    current vitamin B12 recommendations are too low.  Proper vitamin B12 biomarker testing reveals this fact. The problem is most people fall prey to the lack of knowledge behind simple serum levels.  Simple B12 serum levels are woefully inadequate. Insurance would rather one stay with inadequate testing to save money, rather than actually read the science to learn about new testing.
Nathan Goodyear

Improved coronary risk assessment among intermediate risk patients using a clinical and... - 0 views

www.ncbi.nlm.nih.gov/...PMC3666558

CHD coronary heart disease heart disease CHDRA CHD risk assessment assessment

shared by Nathan Goodyear on 01 Nov 16 - No Cached
  • Nathan Goodyear on 01 Nov 16
     
    study suggests biomarkers, CHDRA, with history provides good 5 year CHD risk assessment among those with intermediate risk.
Nathan Goodyear

Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase ... - 0 views

www.hindawi.com/...359879

mercury Hg detoxification catalase superoxide disumutase glutathione peroxidase glutathione selenium

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    Mercury and changes in detoxification biomarkers.
Nathan Goodyear

Fructosamine and glycated albumin for risk stratification and prediction of incident di... - 0 views

www.thelancet.com/...abstract

fructosamine glycated albumin diabetes biomarkers

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Fructosamine and glycated albumin shown to correlate with diabetes and associated microvascular complications.  These biomarkers would compare to HgbA1C diagnostically, but their interval of glycemic evaluation would be less i.e.2-4 weeks versus 3 months with HgbA1c.
Nathan Goodyear

CORONARY ARTERY CALCIUM SCORE VERSUS A MULTIPLE BIOMARKER APPROACH FOR CORONARY HEART D... - 0 views

www.sciencedirect.com/...S0735109713608128

coronary artery calcium CAD CVD cardiovascular disease heart health risk homocysteine BNP

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Coronary artery calcium is positively associated with CAD risk.  It compares to multiple biomarker assessment, BNP, and homocysteine assessment.
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