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Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3099529

TLR toll-like receptors toll-like receptors fatty acids fat metabolic syndrome obesity overweight inflammation dietary

shared by Nathan Goodyear on 08 Oct 12 - No Cached
  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
  • ...10 more annotations...
  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
  • Nathan Goodyear on 08 Oct 12
     
    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

ScienceDirect.com - Physiology & Behavior - The effects of a high-energy diet on hippoc... - 0 views

www.sciencedirect.com/...S0031938412002028

obesity overweight hippocampus brain diet

shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    We have known that diet and brain inflammation were linked.  This study shows a link between, what they call High energy diet (better known as  high calorie, high fat, high carb...), and altered hippocampus brain function.
Barbara Smith

The Health Service That You Truly Deserve - 1 views

I have been suffering from my migraine for several years already. The medicines which I used only gave me temporary relief but did not really solve my problem. I was already hopeless thinking that ...

started by Barbara Smith on 10 Oct 12 no follow-up yet
Nathan Goodyear

Access : Neuroimmunology: Estrogen receptor ligands suppress inflammatory responses in ... - 0 views

www.nature.com/...nrneurol.2011.87.html

ER-beta estrogen receptors receptor MS multiple sclerosis astrocytes microglia microglial cells excitotoxic excitotoxicity disease neurology brain immune hormone hormones

shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    Granted, this study was in an animal model of MS, but signaling through ER-beta was shown to decrease inflammation from astrocytes and microglial cells in the brain.  These immune cells are known to play prominent roles in excitotoxic diseases such as MS.  So, again, it is not just about the message, but also about how the message is interpreted.
Nathan Goodyear

[Effect of physiological doses... [Nan Fang Yi Ke Da Xue Xue Bao. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21269963

low T testosterone mitochondria

shared by Nathan Goodyear on 09 Oct 12 - No Cached
  • Nathan Goodyear on 09 Oct 12
     
    mice study, but low testosterone associated with increased mitochondrial deletions ie.  low testosterone associated with increased aging.
Nathan Goodyear

Sexual Function in Older Women After Oophorectomy : Obstetrics & Gynecology - 0 views

journals.lww.com/...men_After_Oophorectomy.15.aspx

sexual function sex oophorectomy ovaries gynecology women

shared by Nathan Goodyear on 21 Sep 12 - No Cached
  • Nathan Goodyear on 21 Sep 12
     
    Here is my problems with "statistics".  The statement "No significant difference in the report of sexual ideation was found..."  If you are the one women that had decreased sexual function after having your ovaries removed: isn't it comforting to know you are not statistically significant.  Come on.  Some did, and that is enough and should be considered significant.  This is a permanent change to these woman's lives and marriage.
Nathan Goodyear

Acute hypobaric-hypoxia challenge an... [Aviat Space Environ Med. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22779304

stress saliva salivary cortisol DHEA hormone hormones testing space

shared by Nathan Goodyear on 21 Sep 12 - No Cached
  • Nathan Goodyear on 21 Sep 12
     
    saliva used to monitor stress of hypobaric and hypoxic pilots.  Good correlation found to times of hypobaric and hypoxia stress, with pre and post return to normal levels found.  Additionally, DHEA was found to be a component in the stress response of these pilots.
Nathan Goodyear

Homocysteine and Endothelial Dysfunction: A Link with Cardiovascular Disease - 0 views

jn.nutrition.org/...369.full.pdf+html

homocysteine CVD endothelial dysfunction cardiovascular disease ROS reactive oxygen species

shared by Nathan Goodyear on 25 Sep 12 - No Cached
  • Nathan Goodyear on 25 Sep 12
     
    No surprise that homocysteine is associated with vascular dysfunction, when elevated;  But the mechanism is elucidated here through ROS generation.
Nathan Goodyear

The Journal of Nutrition, Health & Aging, Online First™ - SpringerLink - 0 views

www.springerlink.com/...k29u1x4g73057252

selenium inflammation elderly health aging nutrition

shared by Nathan Goodyear on 25 Sep 12 - No Cached
  • Nathan Goodyear on 25 Sep 12
     
    inflammation associated with decreased selenium in the elderly
Nathan Goodyear

Association between circulating specific leukocyte types and blood pressure: the Athero... - 0 views

www.ashjournal.com/...abstract

hypertension blood pressure blood pressure inflammation

shared by Nathan Goodyear on 25 Sep 12 - No Cached
  • Nathan Goodyear on 25 Sep 12
     
    Blood pressure is a s symptom of inflammation.  In this study it was found that elevated neutrophils and decreased lymphocytes was associated with hypertension in the African American population
Nathan Goodyear

ScienceDirect.com - The Journal of Nutritional Biochemistry - The role of dietary fatty... - 0 views

www.sciencedirect.com/...S0955286312000605

metabolic syndrome dietary fatty acids nutritional biochemistry

shared by Nathan Goodyear on 24 Sep 12 - No Cached
  • Nathan Goodyear on 24 Sep 12
     
    disordered fat metabolism plays a role in metabolic syndrome
Nathan Goodyear

Biochemical and metabolic mechanisms by which... [J Nutr Biochem. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22995389

whey protein obesity metabolic syndrome type II DM diabetes

shared by Nathan Goodyear on 24 Sep 12 - No Cached
  • Nathan Goodyear on 24 Sep 12
     
    Whey protein should be a tool in every medical provider to combat obesity and type II Diabetes.  The role? through improved insulin function: by interactions with cholecystokinin, peptide YY, incretins...
Nathan Goodyear

http://www.andrologyjournal.org/cgi/rapidpdf/jandrol.112.016386v1.pdf - 0 views

www.andrologyjournal.org/...jandrol.112.016386v1.pdf

T:E2 testosterone:Estradiol ratio hormone hormones seasonal variations variation men

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    This study looked at T:E2 levels in men for seasonal fluctuations.  What is interesting, is that the T:E2 ratio is at it's lowest during the fall months and highest during the summer months.  This does conflict somewhat with studies that have looked at seasons fluctuations of T alone.  But, it does correlate with changes in body habitus and activity levels.
Nathan Goodyear

Seasonality, waist-to-hip ratio, an... [Psychoneuroendocrinology. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16675146

testosterone seasonal variation hormone hormones saliva salivary

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    another article discusses the seasonal variation of testosterone.  Again, testosterone levels are shown to be highest in the fall months and lowest during the summer months.  This has been found to be the case in both sexes.
Nathan Goodyear

Seasonal variation of salivary testosterone in... [Physiol Behav. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21802437

seasonal variation testosterone hormone hormones

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    interesting study that showed that testosterone levels in men and women fluctuate seasonally.  The highest levels are found in the fall for both sexes, but lowest during the summer.  Interestingly, birth control eliminated these seasonal variations and resulted in a "flatter seasonal testosterone profile".   So, maybe mean cycle, but on a much different time scale?  Interesting thought.
Nathan Goodyear

Rapid determination of natural steroidal hormones in saliva for the clinical diagnoses - 0 views

www.ncbi.nlm.nih.gov/...PMC3351364

hormone hormones saliva salivary testing estrone estradiol estriol progesterone testosterone natural

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    recent study proves the scientific validity of sex hormone evaluation via saliva.  Most labs today use ELIZA.  The new future will be mass spectroscopy.
Nathan Goodyear

Efficacy of Rg3-Enriched Korean Red Ginseng (Steamed Panax Ginseng C.A. Meyer) Extract ... - 0 views

www.fasebj.org/...739.5

korean panax ginseng red clover blood blood pressure pressure Rg3

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    not only does Rg3 appear to be good for a stressed brain, but this study links it to a reduction blood pressure.
Nathan Goodyear

JAMA Network | Archives of General Psychiatry | Depressive Symptoms, Vascular Disease, ... - 0 views

archpsyc.jamanetwork.com/article.aspx

dementia MCI mild cognitive impairment psychiatry vascular disease CVD cardiovascular health

shared by Nathan Goodyear on 02 Oct 12 - No Cached
  • Nathan Goodyear on 02 Oct 12
     
    dementia and depression associated with vascular disease
Nathan Goodyear

Apolipoprotein E, cardiovascular disease and... [Neurobiol Aging. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15653176

APOE apolipoprotein E CVD cardiovascular disease women aging

shared by Nathan Goodyear on 02 Oct 12 - No Cached
  • Nathan Goodyear on 02 Oct 12
     
    APOE allele carriers associated with worse cognitive decline in the elderly.  This was worsened in the presence of CVD.
Rachel Renner

Superb Anti-Snoring Device - 1 views

Noiselezz is the best anti-snoring device that I have ever tried. My wife was about to kick me out of our bedroom until I have found KVG Australia's anti-snoring product. Honestly, I have already t...

started by Rachel Renner on 15 Oct 12 no follow-up yet
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