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Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11958828

Estriol E3 inflammation NF-kappaB Th2 T-cells rheumatoid arthritis RA MS multiple

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
Nathan Goodyear

Treatment of multiple sclerosis with the pregnanc... [Ann Neurol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12325070

MS multiple sclerosis Estriol hormone hormones women multiple sclerosis

shared by Nathan Goodyear on 07 Jan 14 - No Cached
  • Nathan Goodyear on 07 Jan 14
     
    Estriol, the dominant estrogen in pregnancy shown to decrease MS symptoms.  When Estriol was stopped, MS lesions relapsed.  Estriol binds to ERbeta at a rate of 5:1 compared to ER alpha.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views

www.jneurosci.org/...12312.long

Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease

shared by Nathan Goodyear on 17 Mar 15 - No Cached
  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
  • Nathan Goodyear on 17 Mar 15
     
    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Est... - 0 views

www.jimmunol.org/...6267.long

MS RA rheumatoid arthritis psoriasis multiple sclerosis Estriol autoimmune disease inflammation hormone hormones E3

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • A beneficial effect of pregnancy on clinical symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis, uveitis, and thyroiditis
  • In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral immunity
  • Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated autoimmune diseases
  • ...1 more annotation...
  • During pregnancy, there is a shift from Th1 to Th2 that occurs both locally, at the fetal maternal interface, (23, 24, 25), and systemically
  • Nathan Goodyear on 19 Mar 14
     
    MS is in part a Th1 autoimmune disease.  Estriol therapy induces a shift to Th2 through increase in Th10.  Estriol also decreases TNF-alpha cytokine production.
Nathan Goodyear

http://www.anh-usa.org/wp-content/uploads/2010/03/1Estriol_MS_2.pdf - 0 views

www.anh-usa.org/...1Estriol_MS_2.pdf

MS multiple sclerosis Estriol hormones

shared by Nathan Goodyear on 30 Oct 16 - No Cached
  • Nathan Goodyear on 30 Oct 16
     
    High dose Estriol found to be effective therapy in Th1 MS.  This pilot study used 8mg of Estriol daily.
Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

www.ncbi.nlm.nih.gov/...PMC3614637

Estriol Progesterone autoimmune disease inflammation hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
  • ...1 more annotation...
  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
  • Nathan Goodyear on 09 May 16
     
    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Oestrogen and colorectal cancer: mechan... [Int J Colorectal Dis. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23319136

estrogen estriol estradiol estrone colon cancer ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Estrogen early protects against colon cancer, but estrogen increases proliferation late.  The problem here is the estrogens involved.  If ER beta is shown to be highly expressed in the colon, then Estriol would be of benefit as it preferentially binds to ER beta at a rate of 5:1 and Estradiol at a rate of 1:1.  Estriol is currently used in Europe in advanced breast cancer.
Nathan Goodyear

Accuracy of salivary estriol testing compared to t... [Am J Obstet Gynecol. 1999] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...9914620

salivary testing saliva hormones estriol

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • CONCLUSION: Salivary estriol assessment was more accurate in predicting outcome than was modified Creasy scoring.
  • Nathan Goodyear on 24 Nov 10
     
    Accuracy of salivary estriol testing compared to traditional risk factor assessment in predicting preterm birth.
Nathan Goodyear

Salivary estriol as risk assessment for preterm labor: A prospective trial - 0 views

www.ajog.org/...abstract

salivary estriol

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • Detection of an early estriol surge or increased level (≥2.3 ng/ml) may be clinically helpful in identifying women at elevated risk for preterm labor and birth, allowing for evaluation of biologically based interventions in controlled trials.
  • Nathan Goodyear on 18 Jan 11
     
    salivary estriol to assess preterm labor
Nathan Goodyear

Estriol treatment ameliorates disease in male... [J Neuroimmunol. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15020068

Estriol MS multiple Sclerosis disease EAE ER estrogen receptors receptor ER beta ER-beta experimental autoimmune encephalopathy

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Estriol found to be beneficial in experimental model of MS called EAE.  The effect would be through E3's preferential binding to ERbeta.  This study finds benefit in men and women.
Nathan Goodyear

Serial salivary estriol to detect an increased ris... [Obstet Gynecol. 2000] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...11004346

salivary estriol saliva bioidentical testing

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • CONCLUSION: Elevated salivary E3 is associated with increased risk of preterm birth in asymptomatic women and symptomatic women who present for evaluation of preterm labor.
  • Nathan Goodyear on 24 Nov 10
     
    salivary estriol, again, validated n PTL risk assessment
Nathan Goodyear

The Physiologic Role and Use of Estriol - 0 views

www.ijpc.com/...Abstract.cfm

estriol bioidentical hormones breast cancer

shared by Nathan Goodyear on 17 Nov 10 - No Cached
  • Nathan Goodyear on 17 Nov 10
     
    benefits of Estriol in breast cancer risk
Nathan Goodyear

Salivary progesterone and estriol among pregnant w... [Am J Obstet Gynecol. 2008] - Pub... - 1 views

www.ncbi.nlm.nih.gov/...18456237

saliva salivary testing progesteron estriol

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • Nathan Goodyear on 24 Nov 10
     
    saliva testing of progesterone and estriol not questioned, but used to predict outcomes
Nathan Goodyear

Saliva as a fluid for measurement of estriol level... [Am J Obstet Gynecol. 1999] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...9914623

saliva salivary testing estriol

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • Nathan Goodyear on 20 Jan 11
     
    Saliva is a reliable way to assess estriol levels
Nathan Goodyear

Lack of normal increase in saliva estriol/progeste... [Am J Obstet Gynecol. 1992] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...1471666

salivary saliva estriol progesterone

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • Nathan Goodyear on 18 Jan 11
     
    salivary estriol/progesterone in late pregnancy correlates with other studies showing changes in hormone levels at initiation of labor
Nathan Goodyear

Salivary estriol as risk assessment for preterm la... [Am J Obstet Gynecol. 1995] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...7485350

salivary estriol

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • Nathan Goodyear on 18 Jan 11
     
    salivary estriol
Nathan Goodyear

Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor ce... - 0 views

www.ncbi.nlm.nih.gov/...PMC2518256

Estradiol Estrone Estriol Estrogens Estrogen hormone hormones

shared by Nathan Goodyear on 09 Aug 14 - No Cached
  • Nathan Goodyear on 09 Aug 14
     
    good discussion of the nongenomic signaling that occurs from Estradiol, Estrone, and Estriol.
Nathan Goodyear

Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. -... - 0 views

www.ncbi.nlm.nih.gov/...20138962

Estriol breast cancer

shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Estriol found to inhibit GPR30 signaling in ER negative cancer cell study.
Nathan Goodyear

Benefit of pregnancy in inflammatory arthritis -- Straub et al. 64 (6): 801 -- Annals o... - 0 views

ard.bmj.com/801.full

Pregnancy hormones autoimmune disease disease inflammation Estriol Progesterone

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    Pregnancy shifts the immune system to a balance of Th2 expression.  Pregnancy is associated with decrease inflammation i.e. an immunosuppressive state.  Estriol and Progesterone are dominantly produced during pregnancy.   An associated decrease in autoimmune disease is present as a result of the immunosuppressive state of pregnancy.
Nathan Goodyear

Estrogen Treatment in Multiple Sclerosis - 0 views

www.ncbi.nlm.nih.gov/...PMC2760629

Estriol estrogen MS multiple Sclerosis multiple sclerosis hormone hormones

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Good review of the pathogenesis of MS and estrogen therapies effects on MS.  Particularly are the benefits seen with Estriol.
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