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Nathan Goodyear

Sexual Function in Older Women After Oophorectomy : Obstetrics & Gynecology - 0 views

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    Here is my problems with "statistics".  The statement "No significant difference in the report of sexual ideation was found..."  If you are the one women that had decreased sexual function after having your ovaries removed: isn't it comforting to know you are not statistically significant.  Come on.  Some did, and that is enough and should be considered significant.  This is a permanent change to these woman's lives and marriage.
Nathan Goodyear

The Association of Exercise with Both Erectile and Sexual Function in Black and White M... - 0 views

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    Highly active men report better sexual function/performance than less active men, though less active men were not found to have ED or sexual dysfunction.
Nathan Goodyear

The endocrinology of sexual arousal - 0 views

  • A number of age-related changes may be relevant: altered negative feedback of testosterone and hence less increase in luteinizing hormone (LH) with falling testosterone levels, increased sex hormone binding globulin (SHBG) and hence relatively reduced free testosterone and the likelihood of an age-related decline in testosterone receptor sensitivity
  • In the older male, the picture is complicated by various aging effects, including altered hypothalamo–pituitary feedback, increased testosterone binding and reduced receptor sensitivity
  • The neurophysiological basis of NPT is still disputed, but one plausible explanation is that REM sleep is associated with a ‘switching off’ of the noradrenergic cells in the locus coeruleus
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  • the impact of testosterone on the emergence of sexual arousability is less clear
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    Good discussion of the arousal/sexual response differences between men and women from a physiological perspective.  
Nathan Goodyear

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels: T... - 0 views

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    new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!
Nathan Goodyear

Prevalence of Sexual Dysfunction among Postmenopausal Women with and without Metabolic ... - 0 views

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    sexual dysfunction found more in women with metabolic syndrome versus healthy women.
Nathan Goodyear

Persistent sexual dysfunction after discontinuatio... [J Sex Med. 2008] - PubMed result - 0 views

  • SSRIs can cause long-term effects on all aspects of the sexual response cycle that may persist after they are discontinued
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    Sexual side effects often persist long after SSRIs stopped
Nathan Goodyear

Androgens and sexual function: a placebo-controll... [Aging Male. 2009] - PubMed - NCBI - 0 views

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    This study found no benefit from DHEA at 50 mg twice daily for those with androgen deficiency and sexual dysfunction.
Nathan Goodyear

Does increased aromatase activity in adipose fibroblasts cause low sexual desire in pat... - 0 views

  • high oestrogen levels in men do not necessarily result in a fall in androgen levels
  • These high oestrogen levels, therefore, seem capable of decreasing sexual libido and lowering sexual activity
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    Increased aromatase activity and resultant estrogen production negatively effects libido in HIV men.  I don't believe that this effect is just found in those with HIV, but can be extrapolated to all.
Nathan Goodyear

Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and ... - 0 views

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    Beta blocker therapy resulted in decreased sexual activity and serum Testosterone levels compared to AARB therapy.
Nathan Goodyear

The Relationships between Sex Hormones and Sexual Function in Middle-Aged and Older Eur... - 0 views

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    Testosterone, estradiol and sexual function in men
Nathan Goodyear

Levels of estradiol and testosterone are altered in Chinese men with sexual dysfunction... - 0 views

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    Men with sexual dysfunction found to have higher E:T ratio and higher Estradiol overall.  This was a retrospective study.
Nathan Goodyear

Effects of zinc supplementation on sexual behavior of male rats - 0 views

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    rat study finds that zinc supplementation increases Testosterone and prolactin levels, which increase sexual performance.
Nathan Goodyear

Treatment of Men for "Low Testosterone": A Systematic Review - 0 views

  • Of 47 studies that assessed sexual function or satisfaction, 23 studies reported beneficial effects of testosterone treatment for at least 1 measure of sexual function or satisfaction,[6, 26, 35, 37, 40, 43–60] and 24 studies did not show testosterone-associated improvements in any sexual function endpoint
  • Of 31 studies that evaluated erectile function, 15 found no improvement with testosterone therapy
  • Twelve studies included men with ED; 8 found no benefit of testosterone over placebo
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  • Of 23 studies that specifically reported changes in libido, 13 found that testosterone treatment increased libido,[26, 35, 37, 45, 46, 54, 56, 60, 63, 65, 70, 77, 79] eight found no effect,
  • Eleven studies used the Aging Males’ Symptoms scale, which includes 3 questions on libido and sexual function. Five studies found no difference between testosterone and placebo on total scores,[26, 54, 57, 72, 76] and 4 studies found a benefit of testosterone
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    A systemic review of Testosterone benefit in men stirs the pot.  I can't say that I agree with the majority of their conclusions.  What I do agree with them on is that the majority of men on Testosterone therapy likely don't need it and are simply using Testosterone as a drug.
Nathan Goodyear

The role of prolactin levels in the sexual activity ... [BJU Int. 2006] - PubMed - NCBI - 0 views

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    Elevated Prolactin level plays role in ED and reduced sexual activity in men.
Nathan Goodyear

Sexual function and hormone profile in young adult men with idiopathic gynecomastia: Co... - 0 views

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    somewhat flawed study in that they looked at serum sex hormones to evaluate men with gynecomastia compared to controls.  A better eval would have been of saliva or blood spot.  Free levels will show more subtle changes physiologically than will serum as to the sex hormones.  The study did find decreased sexual function in the men with gynecomastia--indicating hormone issues not picked up by the serum.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

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    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

Mary Ann Liebert, Inc. - Journal of Women's Health - 20(4):559 - 0 views

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    BHRT shown to be significantly better for sexual  symptoms than with conventional HRT.  78% vs 33%.
Nathan Goodyear

Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 di... - 0 views

  • up to 40% of men with T2DM have testosterone deficiency
  • Among diabetic patients, a reduction in sex hormone binding globulin levels induced by insulin resistance leads to a further decline of testosterone levels
  • low bioavailable testosterone concentration was related to decreased lean body mass and muscle strength
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  • Testosterone deficiency has a high prevalence in men with T2DM, and it is also associated with impaired insulin sensitivity, increased percentage body fat, central obesity, dyslipidemia, hypertension and cardiovascular diseases (CVD)
  • A meta-analysis of four randomized controlled trials (RCTs) showed that TRT seemed to improve glycemic control as well as fat mass in T2DM subjects with low testosterone levels and sexual dysfunction.
  • testosterone administration could increase muscle mass and strength
  • Insulin stimulates glucose uptake into muscle and adipose tissue via the Glut4 glucose transporter isoform. When insulin activates signaling via the insulin receptor, Glut4 interacts with insulin receptor substrate 1 to initialize intracellular signaling and facilitate glucose transportation into the cell
  • The benefits of TRT on glucose metabolism can mainly be explained by its influence on the insulin signaling pathway
  • Insulin resistance as assessed by, which is calculated from the equation (If*Gf/22.5, where If is fasting insulin and Gf is fasting glucose), was definitely improved by TRT after testosterone administration in three studies
  • Testosterone was observed to elevate the expression levels and stimulate translocation of Glut4 in cultured skeletal muscle cells and to upregulate Glut4 by activating insulin receptor signaling pathways in neonatal rats
  • These effects were inhibited by a dihydrotestosterone (DHT) blocker, indicating that glucose uptake may correlate with conversion of testosterone to DHT and activation of the androgen receptor.
  • TRT reduced triglyceride levels
  • TRT has been reported to have a positive effect in the decrease of total and LDL cholesterol levels and triglycerides in hypogonadal men
  • a recent meta-analysis showed that statins could significantly lower testosterone concentrations.
  • Epidemiological studies have found a negative relationship between testosterone levels and typical cardiovascular risk markers, such as body mass index, waist circumference, visceral adiposity and carotid intima-media thickness.
  • Testosterone treatment was shown to raise hemoglobin, hematocrit and thromboxane, all of which might give rise to CVD
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    Low Testosterone is a very significant problem in men with type II Diabetes.  Estimated to reach 40%, likely much higher.  They based these estimates only on T levels and sexual symptoms. Testosterone improves glycemic control primarily through Increased transcription and transloction of GLUT4 insulin receptors to the cell surface.  Inflammation reduction is also a mechanism.  Testosteorne lowers Triglycerides in the traditional lipid profile.  Studies are mixed on the other aspects of  lipids.  
Nathan Goodyear

Testosterone Supplementation and Sexual Function: ... [J Sex Med. 2014] - PubMed - NCBI - 0 views

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    Meta-analysis finds bias in industry studies versus independent studies.  No surprise there.   Testosterone in this meta-analysis was found to aid sexual dysfunction in men with hypogonadism.
Nathan Goodyear

Effect of Testosterone Treatment on Constitutional and Sexual Symptoms in Men With Type... - 0 views

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    Study finds no improvement in sexual desire and/or ED in older, obese men with Type II diabetes by Testosterone therapy over 40 weeks.   There is so much wrong with this study.  The authors, by design, assume that Testosterone is all there is.  No assessment of Testosterone metabolism and or its effects on inflammation was designed into this study.  These men are known to have increased inflammatory cytokine production and likely are aromatase dominant.  Given these men Testosterone may just be throwing fuel on the biochemical fire.
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