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Nathan Goodyear

Sexual Function in Older Women After Oophorectomy : Obstetrics & Gynecology - 0 views

journals.lww.com/...men_After_Oophorectomy.15.aspx

sexual function sex oophorectomy ovaries gynecology women

shared by Nathan Goodyear on 21 Sep 12 - No Cached
  • Nathan Goodyear on 21 Sep 12
     
    Here is my problems with "statistics".  The statement "No significant difference in the report of sexual ideation was found..."  If you are the one women that had decreased sexual function after having your ovaries removed: isn't it comforting to know you are not statistically significant.  Come on.  Some did, and that is enough and should be considered significant.  This is a permanent change to these woman's lives and marriage.
Nathan Goodyear

Fulltext | Transvaginal mesh procedures for prolapse, analyzing its outcome rates and c... - 0 views

www.hoajonline.com/...4

mesh POP SUI complication erosion

shared by Nathan Goodyear on 07 Aug 16 - No Cached
  • Nathan Goodyear on 07 Aug 16
     
    erosion/extrusion rate of vaginal mesh placement is up to 17.3% in study.
Nathan Goodyear

Maternal 25-Hydroxyvitamin D and Preterm Birth in Twin Gesta... : Obstetrics & Gynecology - 0 views

journals.lww.com/...nd_Preterm_Birth_in.99784.aspx

vitamin D PTD preterm delivery pregnancy

shared by Nathan Goodyear on 07 Jun 13 - No Cached
  • Nathan Goodyear on 07 Jun 13
     
    vitamin D associated with increased Pre term delivery in twin pregnancies.  This is a cohort, so not the most reliable of study designs, but known that vitamin D inhibits inflammation and that this plays a role in labor...logic makes sense.
Nathan Goodyear

Co-occurrence of Cardiovascular and Prothrombotic Risk Facto... : Obstetrics & Gynecology - 0 views

journals.lww.com/...ular_and_Prothrombotic.16.aspx

preeclampsia CVD cardiovascular disease cardiovascular disease obstetrics

shared by Nathan Goodyear on 21 Dec 12 - No Cached
  • Nathan Goodyear on 21 Dec 12
     
    preeclampsia should be a history marker that reveals increased cardiovascular disease (CVD).  
Nathan Goodyear

Cigarette smoking and hormones : Current Opinion in Obstetrics and Gynecology - 0 views

journals.lww.com/...te_smoking_and_hormones.3.aspx

smoking tobacco CYP1A1 CYP1B1 estrogen hormones estrogen metabolism estrogen metabolites

shared by Nathan Goodyear on 05 Dec 16 - No Cached
  • Epidemiologic studies worldwide have established that exposure to cigarette smoke is an important cause of estrogen deficiency.
  • Nathan Goodyear on 05 Dec 16
     
    tobacco smoke alters estrogen metabolism.  Increase in CYP1B1 and CYP1B1 are the result of tobacco smoke.
Nathan Goodyear

Exercise during pregnancy in normal-weight women and risk of preterm birth: a... - 0 views

www.ajog.org/...abstract

exercise pregnancy

shared by Nathan Goodyear on 12 Jul 16 - No Cached
  • Nathan Goodyear on 12 Jul 16
     
    Exercise is not only safe in pregnancy, it is good for the pregnancy and the baby. This idea that pregnancy is a disease or a condition has got to stop; science continues to prove that is not the case.
Nathan Goodyear

Effect of Hysterectomy With Ovarian Preservation on Ovarian... : Obstetrics & Gynecology - 0 views

journals.lww.com/...h_Ovarian_Preservation.10.aspx

ovarian failure hysterectomy premature

shared by Nathan Goodyear on 01 Dec 11 - No Cached
  • Nathan Goodyear on 01 Dec 11
     
    premature ovarian failure shown to be more common post hysterectomy
Nathan Goodyear

Current Issue : Obstetrics & Gynecology - 0 views

journals.lww.com/...currenttoc.aspx

anti-depressants SSRI PMS physical symptoms

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    analysis of 3 clinical trials found that up to 40% of 447 women that were treated with antidepressant therapy found no benefit.  Physical symptoms were provided little, if any benefit.
Nathan Goodyear

Informa Healthcare - Gynecological Endocrinology - 23(5):279 - Summary - 0 views

informahealthcare.com/...09513590701259542

functional hypothyroidism TSH infertility

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    functional hypothyroidism associated with infertility.  Thyroid evaluation doesn't end with TSH.
ind swift

Gynecology Drugs| Pharmaceutical Formulations Development | Indian Drug Manufacturers - 1 views

www.indswiftltd.com/gyno_swift_division.php

DISTONE (IJ) 1X24

shared by ind swift on 14 Aug 12 - No Cached
ind swift liked it
  • ind swift on 14 Aug 12
     
    4 ANAPROCT CAP Each Capsule Contains: Neem (Azadirachta Indica) 25 Mg Suran (Amorphophallus Companulatus) 25 Mg Yashtimadhu (Glycirrhiza Glabra) 25 Mg Haritaki (Terminalia Chebula) 25 Mg Kumarighansatva (Aloe Vera) 50 Mg Mukta Shukti Bhasma(Pearl Oyster) 75 Mg Arishtak (Sapindus Trifoliatus) 75 Mg Saphatika Bhasma (Potash Alum) 100 Mg Daruhaldi Ghansatva(Ext.Berberis Aristata)100 Mg Capsule Anit-Haemorroidal Haemostat 5 ANAPROCT OINTMENT Lidocaine U.S.P.
Nathan Goodyear

WorldSciNet - 0 views

www.worldscinet.com/...S0192415X11008920.html

accupuncture ob_gyn gynecology

shared by Nathan Goodyear on 20 Jun 12 - No Cached
  • Nathan Goodyear on 20 Jun 12
     
    research on acupuncture in ob/gyn is limited.
Nathan Goodyear

Gonadal hormone levels and platelet tryptophan and serotonin concentrations in perimeno... - 0 views

informahealthcare.com/...09513590.2013.875994

depression tryptophan serotonin women perimenopause menopause

shared by Nathan Goodyear on 27 Feb 14 - No Cached
  • Nathan Goodyear on 27 Feb 14
     
    Interesting: study finds no association between tryptophan and serotonin levels and depression.  The study found no difference between 44 "depressed" perimenopausal women and 19 "without depression".  Serotonin therapy of depression??  However, poor sleep and hot flashes did.
Nathan Goodyear

ScienceDirect - Obstetrics & Gynecology : Salivary progesterone concentrations after tu... - 0 views

www.sciencedirect.com/science

saliva salivary testosterone progesterone tubal sterilization

shared by Nathan Goodyear on 19 Jan 11 - No Cached
  • Nathan Goodyear on 19 Jan 11
     
    salivary progesterone levels decrease after tubal sterilization
Nathan Goodyear

Transdermal Ketamine as an Adjuvant for Postoperative Analgesia After Abdominal Gynecol... - 1 views

www.anesthesia-analgesia.org/...1479

transdermal ketamine pain surgery

shared by Nathan Goodyear on 20 Oct 11 - No Cached
  • Nathan Goodyear on 20 Oct 11
     
    transdermal ketamine useful adjunct in post operative pain
Nathan Goodyear

ScienceDirect - Obstetrics & Gynecology : Low whole blood glutathione levels in pregnan... - 0 views

www.sciencedirect.com/...S0029784498003330

glutathione PIH HELLP syndrome pregnancy pregnant GSH detoxification

shared by Nathan Goodyear on 02 Nov 11 - No Cached
  • Nathan Goodyear on 02 Nov 11
     
    glutathione low in pregnancies complicated by PIH and HELLP syndrome. Every woman should have her detoxification capacity evaluated prior to pregnancy.
Nathan Goodyear

Metabolic endotoxaemia - a potential novel link between ovarian inflammation and impair... - 0 views

www.tandfonline.com/...09513590.2014.994602

metabolic endotoxemia progesterone hormones LPS lipopolysaccharides gut inflammation luteal phase defect

shared by Nathan Goodyear on 22 Jun 17 - No Cached
  • Nathan Goodyear on 22 Jun 17
     
    Systemic LPS, metabolic endotoxemia, that is the result of inflammation originating out of the gut found to cause luteal phase dysfunction--low progesterone.  Now, we have the gut-hormone connection.
Nathan Goodyear

American Journal of Obstetrics & Gynecology Home Page - 0 views

www.ajog.org/...fulltext

"Vaginal mesh" immune system

shared by Nathan Goodyear on 31 Aug 18 - No Cached
  • M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
  • M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
  • an overzealous M2 response can also lead to excess tissue deposition and fibrosis
  • ...14 more annotations...
  • Studies of similar meshes that are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
  • the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
  • All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table 3Table 3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
  • Comparison of the ratio of the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P = .003), which indicated a shift towards a proinflammatory profile.
  • Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P < .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P = .001), which supported an ongoing proinflammatory response.
  • the host response was proportional to the amount of material in contact with the host
  • A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
  • The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
  • Mesh-tissue complexes removed for mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
  • The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
  • In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
  • For hernia meshes, if the fibers are too close (<1 mm), the fibrotic response to neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
  • Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
  • mesh shrinkage (50-70%) has been described to occur after transvaginal insertion of prolapse meshes
  • Nathan Goodyear on 31 Aug 18
     
    Mesh and the abnormal immune response.
Nathan Goodyear

Growth Inhibition of Ovarian Tumor-Initiating Cells by Niclosamide | Molecular Cancer T... - 0 views

mct.aacrjournals.org/...1703.long

Niclosamide Tumor-initiation cells TIC ovarian cancer cancer CSC cancer stem cells

shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • Ovarian cancer is the most lethal gynecologic malignancy and the fifth-most cause of overall cancer death of women in developed countries
  • An increasingly accepted cancer stem cell hypothesis regards tumors as caricatures of normal organs, possessing a hierarchy of cell types, at various stages of aberrant differentiation, descended from precursor tumor-initiating cells (TIC) cells that are highly resistant to conventional cytotoxics
  • Significant changes of gene expression in 2,928 genes were identified after niclosamide treatment for different time periods
  • ...14 more annotations...
  • uncoupling of mitochondrial oxidative phosphorylation is believed to be its anti-helminthic mechanism of action
  • we hypothesized that niclosamides antagonistic effects on OTICs could, in part, be due to its disruption of metabolism
  • niclosamide represses metabolic enzymes responsible for bioenergetics, biosynthesis, and redox regulation specifically in OTICs, presumably leading to mitochondrial intrinsic apoptosis pathways, loss of tumor stemness, and growth inhibition
  • niclosamide treatment resulted in a more than 20% increase in reactive oxygen species (ROS) in cultured OTICs
  • niclosamide, which has proved to be safe and effective for the past 2 decades against numerous parasites, inhibited OTIC growth both in vitro and in vivo
  • Our results showed that genes participating in protein complexes of oxidative phosphorylation were downregulated
  • Niclosamide is believed to inhibit mitochondrial oxidative phosphorylation
  • Niclosamide was reported to inactivate NF-κB, causing mitochondrial damage and the generation of ROS, leading to apoptosis of leukemic stem cells
  • niclosamide were identified in a screen for mTOR-signaling inhibitors
  • mTOR was reported to maintain stemness properties of HSCs by inhibiting mitochondrial biogenesis and ROS levels (39), implying that mTOR inhibitors (such as niclosamide) may interfere with mitochondria and various metabolic pathways in TICs via disruption of antioxidant responses
  • We observed Wnt hyperactivity in OTICs, in agreement with previous hypotheses of Wnt inhibitor effectiveness as an ovarian cancer therapy
  • niclosamide has now been independently identified in screens for Wnt inhibitors
  • downregulation of the Wnt/β-catenin target oncogenes survivin and c-Myc
  • ovarian carcinogenesis, the cell-to-cell signaling pathway Notch (8), were also suppressed by niclosamide (data not shown). These results agree with another recent niclosamide study in leukemia (49), and it has been widely hypothesized that disruption of Notch signaling may represent a highly effective therapy for ovarian and other solid tumors, via its essentiality to maintaining TIC stemness
  • Nathan Goodyear on 16 Apr 18
     
    Niclosamide, common anti-parasitic medication, inhibits cellular metabolism and increases ROS; both of which provide powerful anti-proliferative, anti-cancer treatment mechanism in TICs. Powerful target therapy for cancer stem cells. Also shown to inhibit Wnt stimulated oncogenes survivin and c-Myc, disrupts Notch signaling, inactivates NF-kappaBeta, and inhibits mTOR-signaling.  This has been found in in vitro and in vivo studies.
Nathan Goodyear

Oncotarget | Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in... - 0 views

www.oncotarget.com/index.php

Niclosamide cancer ovarian cancer

shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • Ovarian cancer is the most lethal gynecologic malignancy in the world
  • paclitaxel represents a breakthrough in the treatment of ovarian cancer, the overall 5-year survival rate of patients with stage III disease is still approximately 40%
  • Targeting cancer stem cells is an emerging concept in cancer therapy
  • ...8 more annotations...
  • Ovarian cancer stem cells play an important role in chemoresistance and cancer recurrence
  • Furthermore, recent studies indicate that niclosamide exhibits anticancer effects against various human cancer cells by acting on multiple cell signaling pathways and inducing mitochondrial uncoupling [16–21]
  • has low systemic bioavailability (~10%) when administered orally, which is beneficial for treating local parasitic infections of the intestines while minimizing systemic exposure
  • The nano-NI demonstrated significantly higher inhibitory effects on sphere formation than the original niclosamide did
  • the nano-NI formulation decreased the metabolic activity of ovarian cancer cells and caused a metabolic shift from oxidative phosphorylation to glycolysis
  • This toxicity evaluation showed that oral nano-NI had no toxic effect on either group of mice in terms of weight, plasma albumin levels, and blood cell counts, and revealed no adverse effects on vital organ function in the rodents, which suggests that nano-NI is safe for animals
  • niclosamide inhibits tumor cell growth by interrupting multiple pathways (Wnt, Notch, STAT3, NF-κB, and mTORc1) and the generation of reactive oxygen species in several cancer cells
  • The current standard therapy for ovarian cancer includes taxanes and platinum-based chemotherapy after cytoreductive surgery. Among treated patients, nearly 70 to 80% will experience disease recurrence
  • Nathan Goodyear on 16 Apr 18
     
    nano-Niclosamide more effective than traditional Niclosamide in in vitro and in vivo ovarian cancer.
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