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Nathan Goodyear

Loss of expression of oestrogen receptor beta in c... [Oncol Rep. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15944762

ER beta ER-beta colon cancer estrogen receptor estrogen receptors estrogen receptor beta colorectal

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Loss of ER beta associated with higher risk of colon cancer.  ER beta has been shown to be highly expressed in health colons.  It has been proposed that loss of this ER beta expression is associated with carcinogenesis.
Nathan Goodyear

Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucos... - 0 views

www.ejcancer.com/...abstract

ER estrogen receptor estrogen receptors ER beta ER-beta colon colorectal cancer estrogen receptor beta women hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    ER beta expression is dominantly expressed in normal, healthy colon cells/tissue.  However, like in breast and prostate cancer, ER beta expression is lost in the dedifferentiation of colorectal transformation.
Nathan Goodyear

ERβ Has Nongenomic Action in Caveolae: Molecular Endocrinology: Vol 16, No 5 - 0 views

press.endocrine.org/...mend.16.5.0827

ER estrogen receptor estrogen receptors ER-alpha ER alpha ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Estrogen receptors are primarily located inside the nucleus and in the cytoplasm; not on the cell membrane surface. This article specifically focus' on the non-genomic action of ER-beta.  ER-alpha and ER-beta are classic transcription factors.
Nathan Goodyear

Postmenopausal hormone use and risk for color... [Ann Intern Med. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9556463

colon cancer colorectal hormon hormones therapy treatment HRT post menopause women post-menopause

shared by Nathan Goodyear on 09 Jun 14 - No Cached
  • Nathan Goodyear on 09 Jun 14
     
    Study finds that HRT is associated with a 35% reduction in relative risk of colorectal cancer in postmenopausal women.  Even use within the previous 5 years was associated with reduced risk.  This benefit is lost at 5 years..
Nathan Goodyear

Frontiers | Performance enhancement at the cost of potential brain plasticity: neural r... - 0 views

journal.frontiersin.org/...full

psychostimulants stimulants prescription brain neuroscience neuroplasticity methylphenidate amphetamine dopamine norepinephrine serotonin cognition

shared by Nathan Goodyear on 06 Jun 14 - No Cached
  • Nathan Goodyear on 06 Jun 14
     
    Great article on the detriment of prescription stimulants for cognitive enhancement.  The authors describe an inverted "U" efficacy curve.
Nathan Goodyear

Thousands of Toddlers Are Medicated for A.D.H.D., Report Finds, Raising Worries - NYTim... - 0 views

www.nytimes.com/...oses-in-2-and-3-year-olds.html

ADD ADHD children pediatrics

shared by Nathan Goodyear on 06 Jun 14 - No Cached
  • Nathan Goodyear on 06 Jun 14
     
    What are we doing to our children?  Is this what socialized, big government medicine has gotten us?  
Nathan Goodyear

Anandamide modulates human sperm motility: implications for men with asthenozoospermia ... - 0 views

humrep.oxfordjournals.org/...2058.abstract

sperm male fertility marijuana cannabis endocannabinoid system men

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    Study suggests that marijuana negatively alters sperm shape, motility, and function in in vitro study.  This is proposed to occur through disruption of the endocannabinoid system.
Nathan Goodyear

Comprehensive study of urinary cortiso... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16402926

thyroid hypothyroid hypothyroidism hyperthyroidism cortisol metabolites hormones hormone

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    Thyroid effects urinary cortisol metabolites.
Nathan Goodyear

11Beta hydroxysteroid dehydrogenase ty... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17121533

11-betaHSD 11-betaHSD1 muscle hormone hormones

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I dominantly expressed in muscle.
Nathan Goodyear

Microglia express functional 11 beta-hydroxysteroid deh... [Glia. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20544861

11-betaHSD 11-betaHSD1 microglia brain cortisol hormone hormones

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    microglia in the brain express 11 beta-hydroxysteroid dehydrogenase type 1 only.  This consistent with the brain as a whole.
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16184081

endocrine disrupting chemicals hormone hormones cortisol cortisone endocrine disruptors EDC 11-betaHSD 11-betaHSD1 11beta-HSD2

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

Immunohistochemical localization of ... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9543163

11-betaHSD 11-betaHSD1 cortisol hormone hormones ovary liver fat adipose tissue adrenal glands

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I is highly expressed in liver, adrenal glands, ovaries, and adipose tissue in human immunohistochemical analysis.
Nathan Goodyear

Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expres... - 0 views

diabetes.diabetesjournals.org/...2426.long

11-betaHSD 11-betaHSD1 cortisol hormone hormones liver fat adipose tissue adipose tissue

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type 1 is predominantly expressed in liver and adipose tissue.
Nathan Goodyear

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteri... - 0 views

onlinelibrary.wiley.com/...FD615B31CBA2A30EB588D93.f01t03

ovarian cancer SHBG androgens women female

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    prospective study finds that increasing endogenous androgens is associated with low grade epithelial ovarian cancer and inversely associated with high-grade.
Nathan Goodyear

A novel perspective for Alzheimer's disease... [J Alzheimers Dis. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20966550

alzheimer disease alzheimers amyloid-beta vitamin D vitamin d VDR receptor

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    Alzheimer's model finds that amyloid-beta supresses vitamin D receptor.  This study found that vitamin D therapy protected neurons by up regulating vitamin D receptors.  This prevented cytotoxicity and cell death.
Nathan Goodyear

Coconut oil attenuates the effects of amylo... [J Alzheimers Dis. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24150106

coconut oil coconut oil alzheimers mitochondria amyloid-beta

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    Coconut oil found to "rescue" neurons in vitro exposed to amyloid Beta.  It was also found to reduce/protect against mitochondrial damage from amyloid-beta.
Nathan Goodyear

In Utero Exposure to Selective Serotonin... [J Autism Dev Disord. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24803368

SSRI autism ASD autism spectrum disorder anti-depressants pregnancy

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    First do no harm.  That is the underlying code of medicine.  At least what it should be.  Study finds increased autism rates in mothers using SSRI during pregnancy.  Though the rates are small as the study is so clear to point out.  The increased incidence is quite significant--0.7% to 1.5%.
Nathan Goodyear

Total testosterone and sex hormone-binding globuli... [Maturitas. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23218685

low Testosterone T SHBG metabolic syndrome metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    Total Testosterone and SHBG inversely associated with metabolic syndrome in wide age group of Korean men.  This was found to be independent of age and BMI. 
Nathan Goodyear

Association between testosterone levels and the metabolic syndrome in adult men, The Ag... - 0 views

informahealthcare.com/...13685538.2014.913561

low T Testosterone metabolic syndrome metabolic syndrome aging male men hormone hormones

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    In men <45, a declining Testosterone level is associated with an increasing incidence of Metabolic syndrome.  This association was independent of age.  Testosterone was positively associated with HDL and inversely associated with BMI, waist circumference, Triglycerides, Trigylceride:HDL cholesterols, and glucose.
Nathan Goodyear

Erectile dysfunction may be the first clini... [Clin Res Cardiol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23681359

ED erectile dysfunction CVD endothelial dysfunction insulin resistance men male

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    ED may be the earliest of signs for endothelial dysfunction, insulin resistance, and CVD in young men.
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