Skip to main content

Home/ Dr. Goodyear/ Group items tagged hyperthyroidism

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

DISTURBED MINERAL METABOLISM IN HYPERTHYROIDISM: GOOD CORRELATION WITH TRMODOTHYRONINE ... - 0 views

onlinelibrary.wiley.com/...abstract

HYPERTHYROIDISM T3 hypercalcemia phosporus alkaline phosphatase MINERAL METABOLISM

shared by Nathan Goodyear on 09 Sep 11 - No Cached
  • Nathan Goodyear on 09 Sep 11
     
    hyperthyroidism, whether medication induced or iatrogenic, results in elevated calcium, phosphorus, and alkaline phosphates.  The T3 levels show the best correlation
Nathan Goodyear

Subclinical thyroid dysfunctions are independent risk factors for mortality in a 7.5-ye... - 0 views

www.eje-online.org/...569

subclinical thyroid dysfunctions

shared by Nathan Goodyear on 24 Mar 11 - No Cached
  • subclinical hyperthyroidism is an independent risk factor for all-cause and cardiovascular mortality, while subclinical hypothyroidism is associated with all-cause mortality
  • Nathan Goodyear on 24 Mar 11
     
    sub-clinical hypothyroidism and sub-clinical hyperthyroidism associated with increased mortality
Nathan Goodyear

Vitamin D Deficiency Modulates Graves' Hyperthyroidism Induced in BALB/c Mice by Thyrot... - 0 views

www.ncbi.nlm.nih.gov/...PMC2646531

vitamin vitamin d deficiency vitamin D deficiency low vitamin D Graves Graves disease hyperthyroid autoimmune disease autoimmune disease inflammation

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    Low vitamin D plays a role in immune response associated with Graves disease.  This study found small impact, but impact nonetheless.
Nathan Goodyear

Hypovitaminosis D and bone mineral m... [J Clin Densitom. 2010 Oct-Dec] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20663698

vitamin D hyperthyroid HYPERTHYROIDISM bone

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    Hyperthyoid states found to be associated with low vitamin D.  The exact association is unknown.
Nathan Goodyear

Prevalence and significance of steatorrhe... [Am J Gastroenterol. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9672342

Graves disease hyperthyroid hyperthyroidism vitamin D deficiency

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    Graves' disease is associated with a 46% increase in fat malabsorption.  This is important as it relates to the described association with vitamin D deficiency and Graves' disease.  
Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

press.endocrine.org/...jc.2013-3589

depression thyroid elderly TSH

shared by Nathan Goodyear on 16 Apr 14 - No Cached
  • Nathan Goodyear on 16 Apr 14
     
    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Plasma Total Homocysteine in Hyper- and Hypothyroid Patients before and durin... - 0 views

www.clinchem.org/...1738

homocysteine hypothyroid hypothryoidism

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    hypothyroid patients have higher homocysteine levels than hyperthyroid patients; Elevated homocysteine is predictive of cardiovascular disease
Nathan Goodyear

http://www.nature.com/ijo/journal/v24/n2s/pdf/0801281a.pdf?origin=publication_detail - 0 views

www.nature.com/...0801281a.pdf

SHBG IR insulin resistance insulin Estrogen Estradiol obesity hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Elevated insulin levels in men is associated with decreased liver production of SHBG and thus reduced SHBG levels.  Obesity is associated with decreased urinary cortisol in this study.  The authors found the low cortisol also contributed to the low SHBG as well. Low SHBG is associated with puberty, obesity, IR, hypothyroidism, and during androgen therapy.  SHBG is increased as a result of aging, short-term fasting, Estrogen, hyperthyroid, and liver disease.
Nathan Goodyear

Thyroid hormones act indirectly to increase sex hormone-binding globulin prod... - 0 views

jme.endocrinology-journals.org/...19.full

thyroid hormones hypothyroid hyperthyroid SHBG liver

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    Thyroid hormones stimulate SHBG levels.  
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Effects of Hypo- and Hyperthyroidism on Noradrenergic Activity and Glycerol Concentrati... - 0 views

press.endocrine.org/...jc.2003-030576

thyroid hormone adipose tissue adipose fat obesity metabolism noradrenaline norepinephrine

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Thyroid hormone increased localized norepinephrine production and liposlys resulting in decreases SQ adipose tissue compared to hypothyroid.  This study showed a localized effect of adipose tissue by thyroid hormone. 
Nathan Goodyear

Clinical controversies in screening women for thyr... [J Midwifery Womens Health. 2006 ... - 0 views

www.ncbi.nlm.nih.gov/...16647667

TSH screening

shared by Nathan Goodyear on 16 Dec 10 - No Cached
  • In November 2002, the American Association of Clinical Endocrinologists (AACE) released new guidelines for clinical practice for the diagnosis and treatment of hyperthyroidism and hypothyroidism, which includes a new thyroid-stimulating hormone (TSH) reference range of 0.3 to 3.0 mIU/
  • Nathan Goodyear on 16 Dec 10
     
    TSH "screening" needs to be between 0.3 and 3 according to American Association of Clinical Endocrinologists
Nathan Goodyear

Effects of chronic estradiol treatment on the thyr... [BMC Res Notes. 2009] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...19715616

estradiol thyroid function hyperthyroid hypothyroid

shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • Nathan Goodyear on 02 Feb 11
     
    too little/ too much estrogen can negatively effect thyroid function; hormone balance one of the 5 points to health
Nathan Goodyear

Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid ... - 0 views

onlinelibrary.wiley.com/...abstract

thyroid hypothyroid hypothyroidism leptin obesity overweight

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The data are consistent with the hypothesis that leptin and the pituitary–thyroid axis interact in the euthyroid state, and that hypothyroidism reversibly increases leptin concentrations
  • Nathan Goodyear on 08 Mar 11
     
    thyroid and leptin interact to control weight
Nathan Goodyear

Comprehensive study of urinary cortiso... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16402926

thyroid hypothyroid hypothyroidism hyperthyroidism cortisol metabolites hormones hormone

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    Thyroid effects urinary cortisol metabolites.
1 - 16 of 16
Showing 20▼ items per page