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Nathan Goodyear

Monitoring the circadian rhythm of se... [Domest Anim Endocrinol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23688596

saliva salivary cortisol testing HPA hormone hormones

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    Animal study finds very good correlation of salivary cortisol and free plasma cortisol.
Nathan Goodyear

Associations between brain-derived neu... [Neuro Endocrinol Lett. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24977975

BDNF brain derived neurotrophic factor Estradiol Estrogen women female hormone hormones brain health mental

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    BDNF correlates with Estradiol in women.
Nathan Goodyear

Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25135988

post-menopause post menopause women female hormones hormone estradiol estrone testosterone DHEA prolactin SHBG dehydroepiandrosterone breast cancer

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
Nathan Goodyear

Cardiovascular risk associated with tes... [Expert Opin Drug Saf. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25139126

cardiovascular disease risk men male hormone hormones Testosterone low T low Testosterone fat muscle muscle mass metabolism

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Testosterone therapy in men with low Testosterone, over 34 weeks, found to improve metabolism, reduce fat and increase muscle mass and not associated with any increase cardiovascular risk.
Nathan Goodyear

http://qjmed.oxfordjournals.org/content/early/2014/08/18/qjmed.hcu173.full.pdf#page=1&v... - 0 views

qjmed.oxfordjournals.org/...qjmed.hcu173.full.pdf

Testosterone therapy steroids bodybuilding cardiovascular disease risk men male hormone hormones

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Case study published ahead of print--chronic Testosterone use in body building and cardiovascular event in a young man.
Nathan Goodyear

Endocrine actions of pesticides m... [Environ Sci Pollut Res Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25138556

pesticides organophosphates xenoestrogens hormone hormones free T4 TSH sexual development

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    low dose pesticide (organophosphates) exposure associated with delayed sexual development in boys and girls.  In addition, there was an inverse correlation with free T4 and a positive correlation with TSH.  
Nathan Goodyear

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial - 0 views

ajcn.nutrition.org/...1586.abstract

vitamin d vitamin vitamins cancer post-menopause women calcium menopause post-menopausal

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Study finds that optimization of vitamin D and Calcium levels reduces all-cancer risk in postmenopausal women.
Nathan Goodyear

Adverse Effects of Androgen Deprivation Therapy and... [Eur Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25097095

androgen deprivation therapy ADT prostate men male cancer cardiovascular disease obesity diabetes fatigue muscle loss

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Androgen deprivation Therapy is full of risks--of particular is cardiovascular disease, obesity, fatigue, diabetes, insulin resistance...
Nathan Goodyear

Urinary estrogen metabolites in women at high risk for breast cancer - 0 views

carcin.oxfordjournals.org/...1532.full

breast cancer CA estrogen metabolism 2:16 OHE 2-OH-estrone 16-alpha-OH-estrone

shared by Nathan Goodyear on 10 May 12 - No Cached
  • obesity has also been linked to preferential estrogen metabolism via the 16-alpha-hydroxylation pathway; thus, a prediction of the mechanism by which obesity could increase breast cancer risk would be through a lowering of the 2:16 ratio in favor of the 16 pathway
  • increased BMI was associated with a lower 2:16 OHE ratio
  • Our data show a significant association between alcohol use, defined as at least one drink per day or an average of seven per week, and 2:16 OHE ratio
  • ...10 more annotations...
  • An alcohol-induced rise in estrogens as a consequence of alcohol catabolism in the liver has been reported
  • The only study that looked at the association between alcohol and wine consumption in healthy women did not report a clear association
  • smoking has been reported to increase induction of the 2-hydroxylation metabolic pathway (24). However, the few epidemiological studies conducted on healthy women showed no difference in estrogen metabolites with smoking status (22) or smoking dose (20), in line with our findings.
  • Family history of a first-degree family member with breast cancer confers a 2- to 4-fold risk of developing breast cancer
  • 16% of breast cancers are due to unidentified hereditary factors
  • Estrogen metabolism occurs through enzymes whose activity is determined by the presence of specific genetic polymorphisms, thus can be defined as unique to each individual.
  • the metabolism is also influenced by a number of environmental factors, which change over a lifetime
  • significantly lower 2:16 OHE ratio in women who have known breast cancer risk factors compared with healthy women
  • There was an additional significant association specifically with BMI and alcohol use, which also supports the evidence that these factors affect estrogen metabolism
  • Profiling estrogen metabolites may identify women who are more likely to develop breast cancer within a population of women with known risk factors
  • Nathan Goodyear on 10 May 12
     
    urinary estrogen metabolites shown to provide insight into breast cancer risk.  This study suggested that a low 2:16 OHE ratio increase breast cancer risk.
Nathan Goodyear

Urinary Hydroxyestrogens and Breast Cancer Risk among Postmenopausal Women: A Prospecti... - 0 views

cebp.aacrjournals.org/...2137.short

estrogen metabolism estrogen metabolism estrone breast cancer risk post-menopause post menopause HRT hormone therapy 2-OH-estrone

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds increases risk of breast cancer in postmenopausal women on HRT with increased 2OH-estrone metabolism.  Confusing?
Nathan Goodyear

Estrogen Metabolism and Breast Cancer : Epidemiology - 0 views

journals.lww.com/...lism_and_Breast_Cancer.15.aspx

estrogen metabolism estrogen metabolism estrogen metabolite metabolite metabolites breast cancer 2-OH-estrone 16alpha-OH-estrone 2:16alpha-OHE1

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Maybe the risks of estrogen metabolism is age dependent?  This Long Island Breast Cancer Study Project found that an increased 2:16alphOH-estrone ratio was associated with a reduced premenopausal, invasive breast cancer risk.  This association declined when looked at in postmenopausal women.
Nathan Goodyear

Circulating Estrogen Metabolites and Risk for Breast Cancer in Premenopausal Women - 0 views

cebp.aacrjournals.org/...2273.short

estrogen metabolism estrogen metabolite estrogen metabolism breast cancer 2-OH-estrone 16alpha-OH-estrone estrone metabolite metabolites

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Epidemiologic study finds no association between increased 2OH-estrone metabolism and increased 2OH:16alphaOH-estrone metabolism and a reduction in breast cancer risk.
Nathan Goodyear

Delivery mode shapes the acquisition and structure of the initial microbiota across mul... - 0 views

www.ncbi.nlm.nih.gov/...PMC2900693

human microbiome gut flora newborns newborn bacteria delivery mode

shared by Nathan Goodyear on 20 Aug 14 - No Cached
  • Nathan Goodyear on 20 Aug 14
     
    Study finds infants born vaginally have gut flora similar to mother's vaginal flora--Lactobacillus, Prevotella, or Sneathia species.  In contrast, those born via C/S have gut flora similar to that on the skin surface--staphylococcus, corynebacterium...
Nathan Goodyear

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting M... - 0 views

www.cell.com/...S0092-8674(14)00821-6

antibiotics obesity gut flora microbiome bacteria metabolism

shared by Nathan Goodyear on 20 Aug 14 - No Cached
  • Nathan Goodyear on 20 Aug 14
     
    Study finds antibiotics given in late-pregnancy and during first months of life led to obesity in mice via altered gut flora.  This timed exposure was equal to life-time exposure.  This study points to the timing of antibiotic exposure as the key.
Nathan Goodyear

The effect of a low-fat, plant-based lifestyle intervention (CHIP) on serum HDL levels ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3849684

diet nutrition metabolic syndrome metabolism plant-based low fat diet low-fat HDL

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Study finds a decrease in metabolic syndrome parameters with a low-fat, plant-based diet.  Also of note, HDL decreased.
Nathan Goodyear

Chronic fatigue syndrome and mitochondrial dysfunction - 0 views

www.ncbi.nlm.nih.gov/...PMC2680051

mitochondria CFS fatigue chronic fatigues syndrome

shared by Nathan Goodyear on 18 Aug 14 - No Cached
  • Nathan Goodyear on 18 Aug 14
     
    Discussion of the mitochondrial role in chronic fatigue syndrome.  As the authors conclude, there is dysfunction, but whether the cause is primary or secondary or likely varies from individual to individual is yet undetermined.
  • Blu Electronic Cigarettes on 20 Aug 14
     
    very helpful post!
Nathan Goodyear

Association of serum uric acid levels to in... [Pediatr Diabetes. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25131560

obesity obese children uric acid CRP inflammation

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    Obese children found to have elevated uric acid and CRP levels.  The serum uric acid levels were associated with inflammatory biomarkers.
Nathan Goodyear

Lipid-Lowering Effects of Curcumin in Patients... [Phytother Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25131839

metabolic syndrome curcumin tumeric HDL LDL triglycerides cholesterol natural alternative

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    Spice it up for cholesterol.  Study finds small, but significant, improvement in in HDL, LDL, and triglycerides with daily curcumin in those with metabolic syndrome.
Nathan Goodyear

Neuropsychopharmacology - Striatal Dopaminergic and Serotonergic Markers in Human Heroi... - 0 views

www.nature.com/...1395617a.html

dopamine serotonin heroin opiates brain

shared by Nathan Goodyear on 19 Aug 14 - No Cached
  • Nathan Goodyear on 19 Aug 14
     
    study points to a modest decrease in dopamine and serotonin production in heroic users.  There appears to be a decrease in dopamine production, which could be via a down regulation of tyrosine hydroxylase enzyme and thus release.  Decreased homovanillate also noted.  Other studies have pointed to a decrease/downregulation of D2/D3 receptors.
Nathan Goodyear

Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, ... - 0 views

press.endocrine.org/...jc.2014-2555

phthalate phthalates EDC endocrine disrupting chemicals low T low Testosterone low T Testosterone hormone hormones

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Phthalate exposure is a cause of low Testosterone in men, women, and children.   In boys 6-12, exposure was associated with a 24-34% reduction in Testosterone.
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