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Nathan Goodyear

DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and... - 0 views

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    DHA enriched diet plus exercis improved cognition through a increase in brain derived neurotrophic factor (BDNF).  The result was increased neuroplasticity.  Additionally, they were shown to reduce hippocampal lipid peroxidation.
Nathan Goodyear

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of ste... - 0 views

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    Estrogen effects in the hippocampus with BDNF (surprise, surprise) appear to have different effects between the sexes.
Nathan Goodyear

An Overview of Brain-Derived Neurotrophic Factor and Implications for Excitotoxic Vulne... - 0 views

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    great review of BDNF and neurogenesis.
Nathan Goodyear

Brain-derived Neurotrophic Factor in Human Saliva: ELISA Optimization and Biological Co... - 0 views

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    BDNF can be found and followed in saliva
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
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    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

Associations between brain-derived neu... [Neuro Endocrinol Lett. 2014] - PubMed - NCBI - 0 views

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    BDNF correlates with Estradiol in women.
Nathan Goodyear

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway: Cell Metabo... - 0 views

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    Brain benefits of exercise explained.  Exercise increases hippocampal BDNF via PGC-1alpha from skeletal muscle.
Nathan Goodyear

The combined effects of exercise and foods in preventing neurological and cognitive dis... - 0 views

  • The most prevalent types of cognitive impairments include disturbances in attention and learning and memory function
  • An association between BDNF and learning and memory was found when measuring the performance of rats on the Morris water maze task
  • exercise and BDNF have been associated with reducing depression and promoting cognitive enhancement.
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  • In addition to reducing oxidative stress and inflammation, DHA serves to improve neuronal function by supporting synaptic membrane fluidity
  • Curcumin has also been shown to protect the hippocampus and to counteract learning impairment
  • insufficient DHA in the brain can compromise neuronal function with subsequent effects on a broad range of neurological and behavioral faculties.
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    diet and exercise increases BDNF.  Diets rich in omega 3, curcumin, and polyphenols increase BDNF and thus increase neuroplasticity and associated cognition.   In contrast, sugar and saturated fats in crease oxidative stress and worsened spatial learning.  This study is a review.  
Nathan Goodyear

Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects o... - 0 views

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    BDNF increased metabolic biomarkers, MAPK, in hippocampus.  This has implications in the treatment of learning disorders.  Exercise has consistently been shown to be the most significant mechanism to increase BDNF.
Nathan Goodyear

Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after... - 0 views

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    animal study finds that HBOT reduced stroke infarct size, increased neurogenesis, increased BDNF, and reduced MPO.
Nathan Goodyear

Dietary omega-3 fatty acids normalize BDNF lev... [J Neurotrauma. 2004] - PubMed - NCBI - 0 views

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    Another rat study as alot of the studies are with BDNF.  Dietary n-3 reduce oxidative stress and inflammation and increase BDNF.
Nathan Goodyear

Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of P... - 0 views

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    Good discussion of sensory processing disruption, dopamine, and BDNF.  This study specifically looked at a monkey model.
Nathan Goodyear

KoreaMed Synapse - 0 views

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    Stress plays role in BDNF levels.  A decrease in BDNF is found in bipolar patients.  Stress will reduce neuroplasticity through a reduction in BDNF.
Nathan Goodyear

DHA dietary supplementation enhances the effects of exercise on synaptic plasticity and... - 0 views

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    Animal study finds that DHA increases BDNF increasing neuroplasticity.
Nathan Goodyear

Intrathecal epigallocatechin gallate treatment... [Neurochem Res. 2013] - PubMed - NCBI - 0 views

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    This rat model found that EGCG promoted neuro-recovery and neuroprotection through BDNF and GDNF in spinal cord injury model.
Nathan Goodyear

Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusi... - 0 views

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    BDNF promotes neurogenesis in the hippocampus.  BDNF promotes neuroplasticity.
Nathan Goodyear

Scopus preview - Scopus - Document details - 0 views

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    BDNF promotes neurogenesis
Nathan Goodyear

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseas... - 0 views

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    BDNF should be the focus of any cognitive and neurodegenerative disease.
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