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Nathan Goodyear

Erectile dysfunction and coronary disease: Evaluating the link - 0 views

www.maturitas.org/...abstract

ED erectile dysfunction erectile dysfunction cardiovascular disease CVD heart disease

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    ED in men precedes cardiovascular disease by 3-5 years.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

www.neurology.org/...2035.abstract

pesticides disease Parkinson's Parkinson's disease solvents environmental toxins toxins paraquat

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    meta-analysis finds that exposure to pesticide and solvents increase Parkinson's disease by 80%.  One potentially problematic pesticide was paraquat.
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC2701249

DHEA hormone hormones autoimmune disease autoimmune Lupus SLE

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA therapy has provided benefit in autoimmune disease.  IN this study they review the previous articles and physiology behind DHEA's proposed benefit in autoimmune disease.
Nathan Goodyear

Exposure to pesticides or solvents and risk of Parkinson disease - 0 views

www.neurology.org/...2035

pesticides Parkinson's disease PD Parkinson's disease

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Meta-analysis finds link between insecticides and Parkinson's disease.  This is not a political issue.  This is science.
Nathan Goodyear

Cancer as a metabolic disease - 0 views

www.biomedcentral.com/...1743-7075-7-7.pdf

cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Dr. Seyfried provides a different perspective on cancer as a metabolic disease and not as a "genetic" disease as is the current dogma. Dr. Seyfried is well published on this topic and presents valid points to show that a ketogenic diet with intermittent fasting is anti-cancer.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Heart-brain medicine: Update 2008 - 0 views

www.ccjm.org/...S5.full

neurology inflammation psychiatry psychiatric disease CVD cardiovascular depression PTSD

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    It does appear that medicine is moving in the direction of a non-linear approach to disease.  This brief review discusses the early analysis of the relationship of psychiatric conditions, inflammation, and cardiovascular disease.
Nathan Goodyear

Huperzine A for Alzheimer's disease. [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425924

alzheimer disease Alzheimer's disease Alzheimer's Huperzine-A memory cognition

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?
Nathan Goodyear

Long-term effects of finasteride on prostate specific antigen levels: results from the prostate cancer prevention trial. - 0 views

www.ncbi.nlm.nih.gov/...16093979

5 alpha reductase finasteride 5 alpha reductase inhibitors PSA BPH prostate disease cancer men male hormones

shared by Nathan Goodyear on 14 Oct 15 - No Cached
  • Nathan Goodyear on 14 Oct 15
     
    PSA increased more in men with prostate cancer compared to no disease in men on finasteride therapy. This supports the idea that finasteride has a greater PSA reduction in benign prostate disease compared to prostate cancer.
Nathan Goodyear

Benefit of pregnancy in inflammatory arthritis -- Straub et al. 64 (6): 801 -- Annals of the Rheumatic Diseases - 0 views

ard.bmj.com/801.full

Pregnancy hormones autoimmune disease disease inflammation Estriol Progesterone

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    Pregnancy shifts the immune system to a balance of Th2 expression.  Pregnancy is associated with decrease inflammation i.e. an immunosuppressive state.  Estriol and Progesterone are dominantly produced during pregnancy.   An associated decrease in autoimmune disease is present as a result of the immunosuppressive state of pregnancy.
Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

www.ncbi.nlm.nih.gov/...PMC3614637

Estriol Progesterone autoimmune disease inflammation hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
  • ...1 more annotation...
  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
  • Nathan Goodyear on 09 May 16
     
    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25636536

mercury gold nickel lupus autoimmune disease autoimmune disease RA rheumatoid arthritis arthritis Sjogren's

shared by Nathan Goodyear on 26 Sep 16 - No Cached
  • Nathan Goodyear on 26 Sep 16
     
    increased delayed type hypersensitivity reactions in individuals with certain autoimmune diseases.
Nathan Goodyear

ScienceDirect.com - Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology - Borrelia burgdorferi lipopolysaccharide and its role in the pathogenesis of lyme disease - 0 views

www.sciencedirect.com/...S0176672486801158

Lyme borrelia burgdorferi LPS lipopolysaccharides disease microbiology

shared by Nathan Goodyear on 18 Apr 12 - No Cached
  • Nathan Goodyear on 18 Apr 12
     
    Borrelia burgdorferi (lyme disease) shown to express LPS, just like dream negative bacteria.
Nathan Goodyear

Low S-adenosylmethionine concentrations fo... [Clin Chem Lab Med. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15259382

SAMe IBD Crohn's disease Ulcerative Colitis methylation methyl donor

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    SAMe found to be low in those with Crohn's and Ulcerative colitis disease.  Is IBD a methylation disease.  Is IBD a detoxification deficiency state due to lack of methylation?
Nathan Goodyear

Cortisol, Testosterone, and Coronary Heart Disease - 0 views

www.cenegenicsfoundation.org/..._From_The_Caerphilly_Study.pdf

cortisol:testosterone cortisol testosterone ischemic heart disease CVD CAD insulin resistance cardiovascular disease

shared by Nathan Goodyear on 29 Jun 12 - No Cached
  • Nathan Goodyear on 29 Jun 12
     
    Cortisol:Testosterone ratio associated with statistical increase risk of ischemic heart disease. This was mediated through the insulin resistance.
Nathan Goodyear

Glutathione and Parkinson's Disease - ACAM Integrative Medicine (IM) Blog - 0 views

acam.typepad.com/...ne-and-parkinsons-disease.html

IV glutathione Parkinson's disease treatment therapy

shared by Nathan Goodyear on 14 Dec 11 - No Cached
  • Nathan Goodyear on 14 Dec 11
     
    IV glutathione therapy as adjuvant in people with Parkinson's disease
Nathan Goodyear

Environmental Health | Full text | Arsenic in drinking water and cerebrovascular disease, diabetes mellitus, and kidney disease in Michigan: a standardized mortality ratio analysis - 0 views

www.ehjournal.net/4

arsenic diabetes environmental health disease mortality drinking

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    low levels of Arsenic in drinking water in Michigan shown to increase diabetes and other diseases
Nathan Goodyear

IOS Press - Journal Article - 0 views

iospress.metapress.com/...vux3g01201610607

neuroinflammation excitotoxicity inflammation air pollution air pollution Alzheimer's disease IL-6 IL-1 TNF-alpha IFN-gamma

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas.  Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults.  This is the same process found in Alzheimers and other excitotoxicity disease states.  Addtionally, it is also involved in most chronic diseases of aging.
Nathan Goodyear

Influence of Testosterone Therapy on Clinical and Immunological Features of Autoimmune Diseases Associated with Klinefelter's Syndrome - 0 views

jcem.endojournals.org/...32.abstract

testosterone therapy autoimmune diseases disease men male low T inflammation inflammatory cytokines ESR RF ANA

shared by Nathan Goodyear on 12 Aug 12 - No Cached
  • Nathan Goodyear on 12 Aug 12
     
    Testosterone therapy in men with Sjogren's disease and Lupus reduces inflammation (ESR, RF, ANA).  In fact, clinical remission was noted in all patients.
Nathan Goodyear

When and how to evaluate mildly elevated liver enzymes in apparently healthy patients - 0 views

ccjm.org/195.full

elevated liver enzymes non-alcoholic fatty disease (NAFLD)

shared by Nathan Goodyear on 05 Mar 12 - No Cached
  • Nathan Goodyear on 05 Mar 12
     
    with an estimated 25% of Americans with non-alcoholic fatty liver disease (NAFLD), elevated liver enzymes are becoming a more common finding.  Nice review article on what the tests mean and what disease are underlying.
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