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Nathan Goodyear

ESR1 Mutations in Breast Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC6788940

aromatase inhibitor breast cancer aromatase inhibition ESR1 aromatase inhibitors aromatase

shared by Nathan Goodyear on 24 May 21 - No Cached
  • Nathan Goodyear on 24 May 21
     
    ESR1 mutation a result of AI resistance.
Nathan Goodyear

Influence of Testosterone Therapy on Clinical and Immunological Features of Autoimmune ... - 0 views

jcem.endojournals.org/...32.abstract

testosterone therapy autoimmune diseases disease men male low T inflammation inflammatory cytokines ESR RF ANA

shared by Nathan Goodyear on 12 Aug 12 - No Cached
  • Nathan Goodyear on 12 Aug 12
     
    Testosterone therapy in men with Sjogren's disease and Lupus reduces inflammation (ESR, RF, ANA).  In fact, clinical remission was noted in all patients.
Nathan Goodyear

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic... - 0 views

www.ncbi.nlm.nih.gov/...PMC3962576

microglia LDN low dose naltrexone pain inflammation

shared by Nathan Goodyear on 05 Jul 17 - No Cached
  • orally active competitive opioid receptor antagonist
  • 4.5 mg, though the dosage can vary a few milligrams below or above that common value
  • At the low dosage level, naltrexone exhibits paradoxical properties, including analgesia and anti-inflammatory actions
  • ...10 more annotations...
  • LDN may be an effective treatment for FM
  • In addition to the antagonist effect on mu-opioid and other opioid receptors, naltrexone simultaneously has an antagonist effect on non-opioid receptors (Toll-like receptor 4 or TLR4) that are found on macrophages such as microglia
  • It is via the non-opioid antagonist path that LDN is thought to exert its anti-inflammatory effects
  • Once activated, microglia produce inflammatory and excitatory factors that can cause sickness behaviors such as pain sensitivity, fatigue, cognitive disruption, sleep disorders, mood disorders, and general malaise
  • The neuroprotective action appears to result when microglia activation in the brain and spinal cord is inhibited
  • By suppressing microglia activation, naloxone reduces the production of reactive oxygen species and other potentially neuroexcitatory and neurotoxic chemicals
  • suppressed TNF-alpha, IL-6, MCP-1, and other inflammatory agents in peripheral macrophages
  • individuals with greater ESR at baseline experienced a greater drop in pain when taking LDN
  • LDN has been reported to reduce not only self-reported pain in that condition but also objective markers of inflammation and disease severity
  • Naltrexone has also shown some promise in improving disease severity in multiple sclerosis
  • Nathan Goodyear on 05 Jul 17
     
    LDN maybe useful in treating chronic pain via anti-inflammatory effects on microglia.
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