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Nathan Goodyear

Low-dose Interleukin-2 in the Treatment of Autoimmune Disease | touchONCOLOGY - 0 views

www.touchoncology.com/...2-treatment-autoimmune-disease

cancer autoimmune disease Tregs Treg cells Treg immune system disease IL-2

shared by Nathan Goodyear on 04 Apr 18 - No Cached
Amol kashikar liked it
  • affect approximately 5 to 8 % of the US population
  • the incidence and prevalence of autoimmune diseases are rising
  • Type 1 diabetes (T1D), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD) account for the majority of the patients with autoimmune diseases
  • ...9 more annotations...
  • Autoimmune diseases are characterized by a breakdown of mechanisms that allow the immune system to distinguish between self and nonself and maintain immunologic self-tolerance
  • Tregs, which are important in the maintenance of peripheral immune tolerance.
  • Several subtypes of Tregs exist, the most well studied being CD4+ cells that express high-level CD25 and the transcription factor forkhead box P3 (FOXP3)
  • Treg deficiency or dysfunction is associated with autoimmune disease
  • In clinical studies, decreased levels of circulating CD25+CD4+ T cells have been reported in patients with autoimmune disease
  • These data have led to the hypothesis that augmentation of Tregs may be a useful therapeutic strategy in autoimmune disease
  • Treg augmentation has resulted in clinical improvements in numerous animal models of autoimmune diseases
  • the administration of in vitro expanded CD4+CD25highCD127-Tregs has been found to be safe and may help to preserve β-cell function in children with T1D
  • ability of IL-2 to augment the numbers and function of CD4+ Tregs.
  • Nathan Goodyear on 04 Apr 18
     
    Great article.  Immune dysfunction plays role in autoimmune disease and cancer.  Treg cells sit at the center of autoimmunity.  This artice highlights the different uses: low dose IL2 therapy to augment Tregs and reduce autoinflammation and high dose IL2 to augment Treg cells in the fight against cancer.
Nathan Goodyear

Autoimmune Hypogonadism as Part of an Autoimmune Polyglandular Syndrome - 0 views

rsx.sagepub.com/...S52.abstract

polyglandular autoimmune syndrome type 1 hypogonadism autoimmune low T low Testosterone low T Testosterone disease hormones

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    autoimmune hypogonadism is associated with autoimmune polyglandular syndrome type 1.
Nathan Goodyear

Autoimmune Hypogonadism as Part of an Autoimmune Polyglandular Syndrome - 0 views

rsx.sagepub.com/...S52.short

autoimmune hypogonadism polyendocrine syndrome type 1 autoimmune disease APS-1 hormones

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    autoimmune hypogonadism is a common cause of hypogonadism in those with autoimmune polyglandular syndrome.  This is rare outside APS-1.
Nathan Goodyear

Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Est... - 0 views

www.jimmunol.org/...6267.long

MS RA rheumatoid arthritis psoriasis multiple sclerosis Estriol autoimmune disease inflammation hormone hormones E3

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • A beneficial effect of pregnancy on clinical symptoms has been observed in MS and other Th1-mediated autoimmune diseases, including rheumatoid arthritis (RA), psoriasis, uveitis, and thyroiditis
  • In general, Th1 lymphocytes secrete proinflammatory cytokines (e.g., IL-2, IL-12, IFN-γ, and TNF-α) that promote cellular immunity, while Th2 lymphocytes produce anti-inflammatory cytokines (e.g., IL-4, IL-5, IL-6, and IL-10) that promote humoral immunity
  • Th2 cytokines are associated with the down-regulation of Th1 cytokines and may confer protection from Th1-mediated autoimmune diseases
  • ...1 more annotation...
  • During pregnancy, there is a shift from Th1 to Th2 that occurs both locally, at the fetal maternal interface, (23, 24, 25), and systemically
  • Nathan Goodyear on 19 Mar 14
     
    MS is in part a Th1 autoimmune disease.  Estriol therapy induces a shift to Th2 through increase in Th10.  Estriol also decreases TNF-alpha cytokine production.
Nathan Goodyear

Immunotherapy in People with Cancer and Autoimmune Diseases - NCI - 0 views

www.cancer.gov/...immune-diseases-clinical-trial

autoimmune autoimmune disease disease cancer

shared by Nathan Goodyear on 04 Feb 23 - No Cached
  • Nathan Goodyear on 04 Feb 23
     
    Quote that 30% of cancer patients have coexisting autoimmune disease. No real reference for that percentage.
Nathan Goodyear

NK cells in autoimmunity: a two-edg'd weapon o... [Autoimmun Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18486926

natural killer NK autoimmune autoimmune disease autoimmunity

shared by Nathan Goodyear on 04 Feb 13 - No Cached
  • Nathan Goodyear on 04 Feb 13
     
    NK cells play role in autoimmune disease.
Nathan Goodyear

Autoimmunity and Heavy Metals - 0 views

lup.sagepub.com/...449.abstract

autoimmunity heavy metals

shared by Nathan Goodyear on 15 Mar 11 - No Cached
  • Gold may cause autoimmune thrombocytopenia, immune complex-mediated glomerulonephritis and other autoimmune disorders
  • there is solid evidence that mercury can induce autoimmune disease both in humans and experimental animals.
  • Nathan Goodyear on 15 Mar 11
     
    Heavy metals cause some autoimmune diseases
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC2701249

DHEA hormone hormones autoimmune disease autoimmune Lupus SLE

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA therapy has provided benefit in autoimmune disease.  IN this study they review the previous articles and physiology behind DHEA's proposed benefit in autoimmune disease.
Nathan Goodyear

Estriol and Progesterone: A New Role for Sex Hormones - 0 views

www.ncbi.nlm.nih.gov/...PMC3614637

Estriol Progesterone autoimmune disease inflammation hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Pregnancy-associated Th2 shift has been proposed as a mechanism underlying the improvement of Th1-mediated autoimmune diseases (as rheumatoid arthritis, multiple sclerosis (MS), autoimmune thyoriditis, uveitis, and psoriatic arthritis
  • Th2-mediated autoimmune diseases (as systemic lupus erythematosus)
  • During pregnancy PRG serum level increases by a factor of 4, while estrogen estriol (E3) serum concentration increases by a factor of 20
  • ...1 more annotation...
  • In pregnant women at or near term there is a daily production of about 300 μmol (80 mg) of E3 and 1 mmol (300 mg) of PRG
  • Nathan Goodyear on 09 May 16
     
    Estriol and Progesterone associated, as found with pregnancy, associated with decrease in Th1 autoimmune disease.
Nathan Goodyear

Vitamin D and autoimmune thyroid diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC4012880

vitamin d autoimmune disease autoimmune thyroid disease TPO thyroid autoimmune thyroid antibodies

shared by Nathan Goodyear on 07 Feb 16 - No Cached
  • Nathan Goodyear on 07 Feb 16
     
    low vitamin D implicated in increased anti thyroid antibodies and autoimmune thyroid disease.
Nathan Goodyear

Global Academy for Medical Education: Gut inflammation linked to worsening spondyloarth... - 0 views

www.globalacademycme.com/...e01e38e5f99ae7da56c32ddd0.html

autoimmune disease autoimmune disease spondyloarthritis gut inflammation dysbiosis

shared by Nathan Goodyear on 25 Jun 14 - No Cached
  • Nathan Goodyear on 25 Jun 14
     
    Just a press release, but gut inflammation is associated with increased early treatment in those with autoimmune spondyloarthritis compared to those without gut inflammation.  Inflammation clearly plays a role in all autoimmune disease.
Nathan Goodyear

High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome - 0 views

www.eje.org/...363.full.pdf+html

autoimmune thyroiditis autoimmune thyroid disease thyroid PCOS polycystic ovarian syndrome hormone hormoens autoimmune

shared by Nathan Goodyear on 03 Jun 13 - No Cached
  • Nathan Goodyear on 03 Jun 13
     
    Increased rate of autoimmune thyroid disease found in women with the hormonal imbalances found in PCOS.  
Nathan Goodyear

Regulatory NK-Cell Functions in Inflammation and Autoimmunity - 0 views

www.ncbi.nlm.nih.gov/...PMC2710290

NK natural killer inflammation autoimmune autoimmune disease autoimmunity

shared by Nathan Goodyear on 04 Feb 13 - No Cached
  • Nathan Goodyear on 04 Feb 13
     
    good review on NK cell role in inflammation and autoimmune disease
Nathan Goodyear

JAMA Network | JAMA Dermatology | Sex Hormones and the Genesis of Autoimmunity - 0 views

archderm.jamanetwork.com/article.aspx

Hormone hormones autoimmune disease Lupus SLE inflammation

shared by Nathan Goodyear on 31 Jul 13 - No Cached
  • Nathan Goodyear on 31 Jul 13
     
    Hormones and autoimmune disease.  This article specifically touches on SLE.  Good discussion on the biochemical signaling of hormones and their contribution to the increased autoimmunity found in women.
Nathan Goodyear

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Me... - 0 views

www.ncbi.nlm.nih.gov/...PMC3993051

vitamin D TPO autoimmune autoimmune disease autoimmune thyroid disease thyroid hormones

shared by Nathan Goodyear on 07 Feb 16 - No Cached
  • Nathan Goodyear on 07 Feb 16
     
    low vitamin D associated with increased autoimmune thyroid TPO antibodies in women.  This association was found in pre menopause women, but not post menopause women.
Nathan Goodyear

Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurode... - 0 views

www.ncbi.nlm.nih.gov/...PMC2637808

curcumin inflammation disease turmeric natural cardiovascular disease CVD autoimmune disease myeloperoxidase Diabetes IBD inflammatory bowel disease

shared by Nathan Goodyear on 15 Oct 13 - No Cached
  • The starting dose was 500 mg/day and if no toxicity was noted, the dose was then escalated to another level in the order of 1,000, 2,000, 4,000, 8,000, and 12,000 mg/day. There was no treatment-related toxicity up to 8 g/day but the bulky volume of the drug was unacceptable to the patients beyond 8 g/day.
  • The serum concentration of curcumin usually peaked at 1 to 2 hours after oral intake of curcumin and gradually declined within 12 hours
  • Nathan Goodyear on 15 Oct 13
     
    Great article on the benefits of curcumin in therapy for inflammation and disease.
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Nathan Goodyear

Celiac Disease and Autoimmune Thyroid Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2111403

autoimmune thyroid disease hypothyroidism hypothyroid TPO gluten sensitivity gluten celiac disease celiac

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    increased incidence of autoimmune thyroid disease and celiac disease or gluten sensitivity.
Nathan Goodyear

Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease... - 0 views

ebm.rsmjournals.com/...1136.full

low vitamin D vitamin D deficiency vitamin D autoimmune disease autoimmune disease environmental factor

shared by Nathan Goodyear on 15 May 13 - No Cached
  • Nathan Goodyear on 15 May 13
     
    low vitamin D associated with increase prevalence of autoimmune disease.
Nathan Goodyear

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3580532

vitamin d vitamin D T reg Th17 inflammation autoimmune disease lupus SLE

shared by Nathan Goodyear on 31 Jul 13 - No Cached
  • Nathan Goodyear on 31 Jul 13
     
    Vitamin D support provides benefit in those with Lupus.  The proposed mechanism is through the balance of Treg cells and Th17 cells.  This imbalance plays a role in the etiology of autoimmune disease and those with autoimmune disease, such as in Lupus, frequently have low vitamin D levels.
Nathan Goodyear

Autoimmune response following influenza vaccination in... [Lupus. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22235050

autoimmune vaccine vaccination flu

shared by Nathan Goodyear on 11 Nov 13 - No Cached
  • Nathan Goodyear on 11 Nov 13
     
    Flu vaccine shown to induce autoimmune reaction in those with autoimmune inflammatory rheumatic disease and in the healthy as well.
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