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Nathan Goodyear

Long-term effects of finasteride on prostate specific antigen levels: results from the ... - 0 views

www.ncbi.nlm.nih.gov/...16093979

5 alpha reductase finasteride 5 alpha reductase inhibitors PSA BPH prostate disease cancer men male hormones

shared by Nathan Goodyear on 14 Oct 15 - No Cached
  • Nathan Goodyear on 14 Oct 15
     
    PSA increased more in men with prostate cancer compared to no disease in men on finasteride therapy. This supports the idea that finasteride has a greater PSA reduction in benign prostate disease compared to prostate cancer.
Nathan Goodyear

Effect of Finasteride on the Sensitivity of PSA for Detecting Prostate Cancer - 0 views

jnci.oxfordjournals.org/...1128.long

PSA prostate BPH prostate cancer 5 alpha reductase finasteride male hormones men

shared by Nathan Goodyear on 14 Oct 15 - No Cached
  • Nathan Goodyear on 14 Oct 15
     
    Finasteride more likely to lower PSA associated with benign prostate conditions compared to cancer of prostate.
Nathan Goodyear

High-grade prostate cancer and finasteride. - 0 views

www.ncbi.nlm.nih.gov/...19930174

finasteride 5 alpha reductase 5 alpha reductase inhibitors prostate disease cancer men male hormones PSA

shared by Nathan Goodyear on 14 Oct 15 - No Cached
  • Nathan Goodyear on 14 Oct 15
     
    finasteride lacks the 5 alpha reductase specificity (type 1 > 2) for high grade prostate cancer.
Nathan Goodyear

Anaemia in men receiving combined finasteride and fl... [BJU Int. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10233450

anemia testosterone DHT prostate cancer finasteride flutamide

shared by Nathan Goodyear on 02 Sep 11 - No Cached
  • Nathan Goodyear on 02 Sep 11
     
    anti-testosterone therapy with finasteride and flutamide in prostate cancer leads to anemia, proving that testosterone and DHT protect against anemia.
Nathan Goodyear

ingentaconnect Finasteride: A Review of its Use in Male Pattern Hair Loss - 0 views

www.ingentaconnect.com/...art00014

finasteride propecia male-pattern baldness

shared by Nathan Goodyear on 31 Mar 11 - No Cached
  • Nathan Goodyear on 31 Mar 11
     
    finasteride, propecia, improves male-pattern baldness in men
Nathan Goodyear

[The Prostate Cancer Prevention Trial (PCPT). Relevance for clinical practice]. - 0 views

www.ncbi.nlm.nih.gov/...17874228

5 alpha reductase inhibitors 5alpha reductase finasteride prostate disease cancer men male hormones PSA

shared by Nathan Goodyear on 14 Oct 15 - No Cached
  • Nathan Goodyear on 14 Oct 15
     
    Finasteride does not increase prostate cancer.
Nathan Goodyear

Pharmacological approaches to reducing the risk of... [Eur Urol. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19200641

finasteride 5 alpha-reductase inhibitors prostate cancer

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • 5alpha-reductase inhibitors (5-ARIs).
  • there is no evidence that 5-ARIs or any other approach to prostate cancer risk reduction will reduce the risk of lethal prostate cancers
  • Nathan Goodyear on 02 Mar 11
     
    5 alpha-reductase inhibitors, such as finasteride, have not been shown to reduce lethal prostate cancer
Nathan Goodyear

Progesterone-induced stimulation of mammary tumorigenesis is due to the proge... - 0 views

www.sciencedirect.com/...S0960076015000060

5 alpha reductase inhibitors 5 alpha reductase progesterone 5alpha-pregnane breast cancer

shared by Nathan Goodyear on 07 Jul 20 - No Cached
  • Nathan Goodyear on 07 Jul 20
     
    5 alpha reductase inhibitor, finasteride inhibits pro-tumor progesterone metabolite pathway.
Nathan Goodyear

Clinical dose ranging studies with finasteride, a type 2 5α-reductase inhibit... - 0 views

www.eblue.org/...abstract

finasteride propecia male-pattern baldness

shared by Nathan Goodyear on 31 Mar 11 - No Cached
  • Nathan Goodyear on 31 Mar 11
     
    propecia, 5-alpha reductase inhibitor, improves male pattern baldness
Nathan Goodyear

An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and... - 0 views

www.pnas.org/...13589.full

3-beta androstanediol DHT metabolite prostate cancer ER-beta ER beta CYP7b1 cytochrome male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Although the prostate is an androgen-dependent tissue, estrogens influence both normal functions and pathological changes in this gland
  • This dual action may be due to the existence of two estrogen receptors, ERα and ERβ
  • ERα and ERβ have similar affinities for estradiol-17β
  • ...6 more annotations...
  • In this study we have shown that regulation of the levels of 3βAdiol by CYP7B1 is a key factor in regulation of prostatic growth
  • We provide evidence that proliferating cells in the prostate epithelium have elevated levels of AR and that AR protein but not mRNA levels are regulated by ERβ and its ligand 3βAdiol in the prostate epithelium.
  • because inhibition of 5α-reductase causes accumulation of testosterone and removal of ERβ action increases the level of AR in the prostate, the overall effect of Finasteride would be to favor proliferation of the prostate epithelium
  • studies show that ERβ tends to be lost in advanced prostate cancer.
  • DHEA is converted in the body to 5-androstene-3β,17β-diol, which is also a ligand for estrogen receptors (25, 39) and a substrate for CYP7B1
  • At the peak of proliferation, the proliferating epithelial cells in the ventral prostate expressed high levels of CYP7B1 but had no detectable ERβ, whereas in nonproliferating cells the level of ERβ was high and that of CYP7B1 was low.
  • Nathan Goodyear on 27 Jan 14
     
    3-beta androstanediola, a product of 3alpha-HSD from DHT binds to ER beta and down regulates AR in prostate cancer.  This study proposes that the mechanism is via CYP7B1.  CYP7B1 inactivates 3-beta androstanediol.  Interesting, because 3-beta androstanediol is considered "inactive" when compared to 3-alpha androstanediol and its interaction with ER alpha.  
Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Cognitive effects of testosterone and finasteride administration in older hypogonadal men - 0 views

www.ncbi.nlm.nih.gov/...PMC4136953

aging men male low T low Testosterone cognition depression hormone hormones testosterone

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Testosterone found to provide small improvement in depression in men > 60 and starting serum Testosterone levels < 300.  Small improvement in cognition also noted.  
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