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SAMe found to be low in those with Crohn's and Ulcerative colitis disease.  Is IBD a methylation disease?  Is IBD a detoxification deficiency state due to lack of methylation?

Great review on methylation.

SAMe shown to lower liver toxicity in chemotherapy treatment.  SAMe could be a powerful chemotherapeutic adjuvant.  This makes since, because cancer is known to be a hypomethylated state.  Low methyl donors will reduce CBS activity and thus lower glutathione.  This will result in increased oxidative stress and inflammation in the liver.  SAMe will open the CBS activity up and increase glutathione production.

SAMe, at doses of 1200 mg, shown to decrease mortality rate and prolong transplantation in those with cirrhosis.  Very likely, these individuals, if tested, had low SAMe and methyl donors as well as depleted glutathione. This is a set up for low phosphotidyl choline/ethanolamine levels resulting in fat accumulation.

SAMe helps to correct disordered homocysteine metabolism due to B- vitamin deficiency found in Alzheimer's disease.  SAMe show to reduce amyloid production, improve memory, decrease Tau, and reduced plaque formation.  Now, this was in a mice model, but SAMe as a methyl donor can benefit clients with dementia with minimal side effects.