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Nathan Goodyear

1210_article_14 - 0 views

jpp.krakow.pl/...14_article.html

neurotoxic thimerosal vaccinations

shared by Nathan Goodyear on 03 Apr 11 - No Cached
  • These modulatory effects - which most likely involve binding with functional thiol residues - are interwoven with neurotoxic actions of both mercurials.
  • THIM is metabolized in the body to ethyl mercury (EtHg) and subsequently to inorganic mercury forms, which accumulate in tissues of vital organs, including the brain (22). Information about neurochemical and neurotoxic effects of THIM is still limited, but the existing data indicate that in pharmacodynamics and toxicity THIM/EtHg does not differ significantly from methyl mercury (MeHg), which has been studied more extensively, although these compounds differ somewhat in pharmacokinetics (8).
  • Several studies documented that the neurotoxic effects of mercurials involve glutamate-mediated excitotoxicty, due to their ability to inhibit uptake of glutamate in astrocytes, resulting in an increase of the extracellular level of this excitatory amino acid
  • Nathan Goodyear on 03 Apr 11
     
    neurotoxic effects of thimerosal
Nathan Goodyear

In vitro neurotoxicity of methylisothiazolinone, ... [J Neurosci. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12196562

methylisothiazolinone MI neurotoxic neurology brain neurotoxicity

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Scary.  Common component of many OTC creams and ointments contain chemical, methylisothiazolinone that is neurotoxic.
Nathan Goodyear

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates - 0 views

www.ncbi.nlm.nih.gov/...PMC2661898

Mn manganese brain neurotoxicity

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    nice discussion of the biochemical mechanism that Manganese leads to neurotoxicity.
Nathan Goodyear

Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms - 0 views

www.pnas.org/...18569.abstract

lupus brain function neurotoxic autoantibodies

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • Nathan Goodyear on 03 Mar 11
     
    neurotoxic effects in clients with Lupus
Nathan Goodyear

Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity - 0 views

www.jneurosci.org/...6125.abstract

mitochondrial dysfunction

shared by Nathan Goodyear on 03 Mar 11 - No Cached
  • These results suggest that early mitochondrial damage plays a key role in induction of glutamate neurotoxicity.
  • Nathan Goodyear on 03 Mar 11
     
    mitochondrial dysfunction and neurotoxicity
Nathan Goodyear

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of... - 0 views

brain.oxfordjournals.org/...1259.short

kynurenine inhibition inflammation neurotoxicity

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • A number of the catabolites produced along this pathway show neurotoxic or neuroprotective activities, and their role in the generation of central nervous system inflammation is well documented.
  • Nathan Goodyear on 12 Apr 11
     
    kyneurenine pathway leads to CNS inflammation and neurotoxicity
Nathan Goodyear

Involvement of environmental merc... [Rev Environ Health. 2006 Apr-Jun] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16898674

mercury lead Pb Hg glial cell microglia brain inflammation oxidative neurotoxicity

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    environmental mercury and lead shown to act synergistically to activate glial cell activity.  This glial cell activity is associated with oxidative stress, inflammation and neurotoxicity.
Nathan Goodyear

The syndrome of irreversible lithium-effectuated n... [Clin Neuropharmacol. 2005 Jan-Fe... - 0 views

www.ncbi.nlm.nih.gov/...15714160

Lithium neurotoxicity

shared by Nathan Goodyear on 10 Dec 10 - No Cached
  • Nathan Goodyear on 10 Dec 10
     
    Silent but irreversible lithium-induced neurotoxicity
Nathan Goodyear

Aluminum vaccine adjuvants appear to contribute to the rising - 0 views

www.greenmedinfo.com/...ibute-rising-prevalence-autism

aluminum vaccine autism ASD

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    some relationship is suggested to exist between Aluminum and autism. So much attention is given to thermerosol, yet aluminum in its own right has been shown to be neurotoxic.  Aluminum is a common component of the flu vaccine 
Nathan Goodyear

Changes in the number of astrocytes and micr... [Neurotoxicology. 1996] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8784824

methylmercury brain inorganic mercury astrocyte microglia

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    low methylmercury shown to accumulate in the brains of monkeys in the form of inorganic mercury.  Specifically, astrocytes and microglial cells accumulated the inorganic mercury.  Long-term low exposure can result in neuro-accumulation of inorganic mercury and neurotoxicity.
Nathan Goodyear

Methylmercury induces oxidative injury, alterations in permeability and glutamine trans... - 0 views

www.ncbi.nlm.nih.gov/...PMC1847599

methylmercury mercury astrocytes glutamate mitochondria brain inflammation oxidative ROS

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    methylmercury mediates neurotoxicity via mitochondrial damage, inflammation, and oxidative stress.  Astrocytes accumulated the methyl mercury.  The destruction of the astrocytes will result in an increase in glutamate.  Methylmercury is synergistic with other toxins in the development of immunoexcitotoxicity.
Nathan Goodyear

PLOS ONE: Metal and Silicate Particles Including Nanoparticles Are Present in Electroni... - 0 views

www.plosone.org/...journal.pone.0057987

electronic cigarette cigarette metals

shared by Nathan Goodyear on 23 Nov 13 - No Cached
  • Nathan Goodyear on 23 Nov 13
     
    study finds equal parts of metal contaminants and silica in electronic cigarettes as in regular cigarettes.  One example is aluminum.  Aluminum is incredibly neurotoxic.
Nathan Goodyear

SpringerLink - Neurotoxicity Research, Volume 15, Number 1 - 0 views

www.springerlink.com/...c8v25k2418440257

neurotoxicity Parkinson's disease Grape seed extract curcumin

shared by Nathan Goodyear on 13 May 11 - No Cached
  • myloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively
  • Curcumin also significantly reduced brain Aβ burden and microglia activation
  • polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD.
  • Nathan Goodyear on 13 May 11
     
    Grape seed extract and curcumin shown to reduce amyloid plaques and reduce inflammation in the brain: promising treatment in Alzheimers disease
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC2689399

hormones MS multiple Sclerosis Estriol progesterone

shared by Nathan Goodyear on 11 Jan 17 - No Cached
  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
  • ...12 more annotations...
  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
  • Nathan Goodyear on 11 Jan 17
     
    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Calcium: A target in the war on Alzheimer's disease - 0 views

dl-web.dropbox.com/...heimers_Disease_WhitePaper.pdf

Alzheimer's disease excitotoxicity neurotoxicity calcium

shared by Nathan Goodyear on 17 Feb 12 - No Cached
  • Nathan Goodyear on 17 Feb 12
     
    good discussion on Alzheimer's disease and the role of calcium
Nathan Goodyear

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimu... - 0 views

www.jneurosci.org/...558.full

microglia microglial cells inflammation Alzheimer's disease neurodegenerative

shared by Nathan Goodyear on 06 Jan 12 - No Cached
  • The activated microglia mount a complex local proinflammatory response
  • PPARγ plays a critical role in regulating the inflammatory responses of microglia and monocytes to β-amyloid
  • Nathan Goodyear on 06 Jan 12
     
    microglial and inflammatory response in Alzheimer's disease.  Agonists of PPAR-gamma inhibit this action.  This has important implications in reducing the local inflammatory response found in the brains of those with Alzheimers and other neuordegenerative disease.
Nathan Goodyear

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity - Gash - 2007... - 0 views

onlinelibrary.wiley.com/...abstract

TCE environmental toxins mitochondria Parkinson's Disease PD

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    TCE shown to mitochondrial toxic and risk factor for Parkinson's disease
Nathan Goodyear

Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease: National I... - 0 views

www.ninds.nih.gov/...kinsons_coenzymeq10_101402.htm

CoQ10 Parkinson's disease Huntington's ecitotoxic neurotoxic

shared by Nathan Goodyear on 07 Nov 11 - Cached
  • Nathan Goodyear on 07 Nov 11
     
    high dose CoQ10 shown to slow disease progression in Parkinson's disease.  A similar study had shown the same finding in Huntington's disease.  Both are excitotoxic diseases
Nathan Goodyear

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimu... - 0 views

www.jneurosci.org/...558.long

inflammation AD alzheimer's neurodegenerative disease PPAR-gamma PPAR microglial alzheimer

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • PPARγ agonists were shown to inhibit the β-amyloid-stimulated expression of the cytokine genes interleukin-6 and tumor necrosis factor α. Furthermore, PPARγ agonists inhibited the expression of cyclooxygenase-2.
  • Nathan Goodyear on 11 Jun 12
     
    Not that we are recommending NSAIDS to reduce inflammation: but the learned biochemical pathways of inflammation involved with AD, allows a natural approach to reduce microglial associated inflammation through PPAR-gamma activation.
Nathan Goodyear

Curcumin attenuates aluminum-induced oxidative ... [Neurotox Res. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21656326

curcumin oxidative stress inflammation mitochondria aluminum AL vaccine vaccination brain neurology

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    Curcumin shown to inhibit oxidative stress, inflammation, and mitochondrial damage caused by Aluminum in rat brain.  Aluminum's effect is not just confined to rat models.  It is well known to cause similar results in the human brain as well.  what is interesting about this article is the clear pathway disruption described as a result of Aluminum exposure.
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