ARG plus GHRH test, high sensitivity (96 and 95%, respectively) and specificity (92 and 91%, respectively) for GH deficiency were achieved
The greatest diagnostic accuracy occurred with the ITT and the ARG plus GHRH test
95% specificity could be achieved with the ARG plus L-DOPA and ARG tests only with very low peak GH cut-points (0.25 and 0.21 microg/liter, respectively) and not at all with the L-DOPA test
Although serum IGF-I levels provided less diagnostic discrimination than all five GH stimulation tests, a value below 77.2 microg/liter was 95% specific for GH deficiency
study evaluated 6 tests for HGH deficiency diagnosis. Ninety-five percent specificity found with ARG + l-DOPA and ARG alone. However, the authors found a 95% specificity with IGF-1 < 77. Although, IGF-1 is false negative in up to 65% of those with HGH deficiency.
good article discussing the positive impact of IGF-1 on atherosclerosis. This hormone, under the control of HGH, is important in the healing and regenerative process. Thus, the use of the term "anti-aging". However, these two hormones simply help the body heal, repair, and regenerate itself. Not surprising, inflammation (TNF-alpha) counteracts these positive effects.
HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...
testosterone and Estradiol effect IGF-1 levels. This small study looked at 8 men and 8 postmenopausal women. Findings: low testosterone and high estradiol decrease IGF-1 availability. Estradiol in postmenopausal women will result in a decrease in IGF-1 through an elevation of IGFBP-1. In men, testosterone replacement stimulates increased HGH secretion and resultant IGF-1 secretion
Testosterone given to elderly men with low "serum" testosterone shown to increase IGF-1 and increased muscle growth and strength. So, this study shows that testosterone in men, seems to increase HGH production and thus increase IGF-1 production. This may be the mechanism by which testosterone promotes muscle growth and increase in strength in men.
oral estrogen therapy decreased IGF-1 concentrations in those women taking growth hormone, requiring high dosing of HGH versus that in women using estrogen through a transdermal approach.
Birth control pills were found to reduce IGF-1 levels in the short term and long term. Those that had used birth control pills had lower IGF-1 levels compared to those that had never used birth control pills. This fits with the current knowledge that oral estrogen reduces HGH and IGF-1. Those were in post-menopausal women, but this is in pre-menopaus women. This has implications on health, weight, disease...
epidemiological studies are the only thing that has linked GH to cancer risk; review of human studies of children and adults finds no increase risk of cancer associated with HGH therapy.
These data also suggest that endogenous progesterone could play a modulation role on pituitary hormone secretion, stimulating GH and PRL release and enhancing the inhibitory action of sleep on TSH secretion.
normally cycling young women, daytime GH and PRL secretions are increased in luteal phase