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Data from MESA study finds that increasing endogenous Estradiol, Total and free Testosterone, DHEA, and lower SHBG were associated with hypertension in postmenopausal women.

testosterone and Estradiol effect IGF-1 levels.  This small study looked at 8 men and 8 postmenopausal women.  Findings:  low testosterone and high estradiol decrease IGF-1 availability.   Estradiol in postmenopausal women will result in a decrease in IGF-1 through an elevation of IGFBP-1.  In men, testosterone replacement stimulates increased HGH secretion and resultant IGF-1 secretion

Weight loss in postmenopausal women reduces crp levels.  Translated: weight loss reduces fat induced inflammation and thus Cardiovascular disease.

New study reveals that statin drug of any kind increases the risk of type II diabetes by 48% in postmenopausal women

Statin drugs shown to increase risk of Diabetes in postmenopausal women

intake of sugar drinks i.e. coke associated with increased risk of type I endometrial cancer in postmenopausal women.

Study finds that lower SHBG, higher Estradiol, Estrone, Testosterone levels, and free androgen index is associated with increased CRP in "healthy" postmenopausal women.

In women, the postmenopause state is associated with a decrease in SHBG, and increase in free Testosterone and Estradiol.  No increase in Total Testosterone was found in this study.  This was associated with increased insulin resistance and MetS.

Increase in free Testosterone, DHEA, and Estradiol in postmenopause women associated with increase in insulin resistance.

Estrogen therapy in women recently postmenopausal, found to improve symptoms of depression and anxiety.  The mean age of women in this study was 52.7.  Average age of menopause is 51, so apprx 1 year postmenopausal in this study.  Both premarin and bioidentical estradiol was used in different arms of the study.  Bioidentical progesterone was used in all 3 arms.

Low DHEA in postmenopausal women linked to increased risk of mortality, especially Cardiovascular

myo-inositol proven to be a good treatment for those postmenopausal women with metabolic syndrome

Calcium increases cardiovascular events in postmenopausal women.  Levels must be checked for any nutrient prior to starting therapy to ensure appropriate therapy.

Phytoestrogens improve dry eyes in postmenopausal women.

this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.

low free Testosterone shown to increase mortality risk in postmenopausal, diabetic women.  No association was found with total testosterone or SHBG

study of 80,377 postmenopausal women found no increase/decrease in breast cancer in women on estradiol and progesterone (RR 1.0).  However, estradiol and provera (synthetic progestin) found a 69% increased breast cancer risk (RR 1.69).

high carbohydrate intake associated with increased risk of ER/PR negative breast cancer in Postmenopausal women.

Estrogen important in reducing neuroinflammation in Parkinson's disease in postmenopausal women?

Higher Testosterone and low SHBG  in postmenopausal women is associated with increased CVD risk