Group items tagged models - Dr. Goodyear

Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15932748

progesterone treatment brain inflammation neurology NF-kapppB cytokines inflammatory TBI traumatic brain injury

shared by Nathan Goodyear on 09 Jul 12 - No Cached

Nathan Goodyear on 09 Jul 12

progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.</div>

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IOS Press - Journal Article - 0 views

iospress.metapress.com/...c828m5t46j6850x5

progesterone hormone hormones neuroprotection brain neurology

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

progesterone shown to have neuroprotective effects in brain ischemic rat model.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to have neuroprotective effects in brain ischemic rat model.</div>

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Effects of progesterone administration on infarct volume and functional deficits follow... - 0 views

www.ncbi.nlm.nih.gov/...PMC2656912

progesterone hormone hormones brain neurology

shared by Nathan Goodyear on 10 Jul 12 - No Cached

Nathan Goodyear on 10 Jul 12

progesterone shown to provide substantial reduction in volume of infarct in rat stroke model. This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.

<div class="cArrow"> </div><div class="cContentInner">progesterone shown to provide substantial reduction in volume of infarct in rat stroke model. This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.</div>

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Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of ... - 0 views

circ.ahajournals.org/...1605.long

estradiol estrogen EPCs MI CVD endothelial progenitor cells hormone hormones

shared by Nathan Goodyear on 11 Jul 12 - No Cached

Nathan Goodyear on 11 Jul 12

Estradiol shown to increase EPC activity post MI in female MI rat model

<div class="cArrow"> </div><div class="cContentInner">Estradiol shown to increase EPC activity post MI in female MI rat model</div>

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Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice - 0 views

diabetes.diabetesjournals.org/...2574.full

obesity overweight weight-loss M1 macrophage M2 ATM inflammation TNF-alpha IL-6

shared by Nathan Goodyear on 03 Jan 12 - No Cached

Nathan Goodyear on 03 Jan 12

M1 macrophages (and a high M1/M2 ratio) promote inflammation and insulin resistance in obese individuals; This is in contrast to M2 macrophages. Obese individuals will see a shift in M2 to M1. The exact mechanism is yet unknown. But M2 macrophages have been shown to resolve insulin resistance in this obese mice model

<div class="cArrow"> </div><div class="cContentInner">M1 macrophages (and a high M1/M2 ratio) promote inflammation and insulin resistance in obese individuals; This is in contrast to M2 macrophages. Obese individuals will see a shift in M2 to M1. The exact mechanism is yet unknown. But M2 macrophages have been shown to resolve insulin resistance in this obese mice model</div>

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Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse mode... - 0 views

www.greenmedinfo.com/...ibit-breast-cancer-mouse-model

curcumin NF-KappaB inflammation breast cancer CA

shared by Nathan Goodyear on 19 Jan 12 - No Cached

Nathan Goodyear on 19 Jan 12

curcumin shown to augment paclitaxel in breast cancer treatment. Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased apoptosis, and decreased MM-9.

<div class="cArrow"> </div><div class="cContentInner">curcumin shown to augment paclitaxel in breast cancer treatment. Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased apoptosis, and decreased MM-9.</div>

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Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in... - 0 views

endo.endojournals.org/...5340.full

LPS lipopolysaccharides inflammation obesity NF-KappaB insulin resistance IR

shared by Nathan Goodyear on 19 Jan 12 - No Cached

Nathan Goodyear on 19 Jan 12

proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade. This plays a key role in the obesity epidemic.

<div class="cArrow"> </div><div class="cContentInner">proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade. This plays a key role in the obesity epidemic.</div>

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Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats - 0 views

ajpendo.physiology.org/...E949.full

leptin gherlin obesity overweight weight-loss weight

shared by Nathan Goodyear on 21 Nov 11 - No Cached

Nathan Goodyear on 21 Nov 11

leptin sensitivity and not gherlin shown to play role in obesity in Diet induce obesity rat model

<div class="cArrow"> </div><div class="cContentInner">leptin sensitivity and not gherlin shown to play role in obesity in Diet induce obesity rat model</div>

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GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin... - 0 views

www.ncbi.nlm.nih.gov/...PMC2956412

Omega-3 n-3 DHA EPA inflammation insulin diabetes DM GPR120 receptor cytokines

shared by Nathan Goodyear on 16 Jul 12 - No Cached

Nathan Goodyear on 16 Jul 12

Omega-3, DHA and EPA, exert anti-inflammatory effects through GPR120 receptor. This improved insulin sensitivity and had diabetes effects in-vivo model. The effect was through the reduction of macrophage-induced inflammatory cytokines.

<div class="cArrow"> </div><div class="cContentInner">Omega-3, DHA and EPA, exert anti-inflammatory effects through GPR120 receptor. This improved insulin sensitivity and had diabetes effects in-vivo model. The effect was through the reduction of macrophage-induced inflammatory cytokines.</div>

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Caloric restriction increases adiponectin expression by adipose tissue and prevents the... - 0 views

www.jnutbio.com/...abstract

calorie restriction adiponectin insulin resistance adipocytes fat tissue cells overweight obesity

shared by Nathan Goodyear on 31 Jul 12 - No Cached

Nathan Goodyear on 31 Jul 12

Calorie restriction increases adiponectin secretion from adipocytes. Another plus of calorie restriction. Remember, adiponectin and insulin are inversely associated. Granted, this is in a rat model, but still supporting the overall health benefits of calorie restriction.

<div class="cArrow"> </div><div class="cContentInner">Calorie restriction increases adiponectin secretion from adipocytes. Another plus of calorie restriction. Remember, adiponectin and insulin are inversely associated. Granted, this is in a rat model, but still supporting the overall health benefits of calorie restriction.</div>

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Estrogen receptor (ER) β, a modulator of ERα in the uterus - 0 views

www.pnas.org/...5936.full

receptors ER-alpha ER-beta hormones hormone

shared by Nathan Goodyear on 16 Aug 12 - No Cached

induction of PR is an ERα-mediated event and repression of epithelial PR is ERβ mediated.
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Nathan Goodyear on 16 Aug 12

ER alpha and ER beta have different effects on the uterus in this mice model. ER beta modulates ER alpha. ER beta decreases PR, whereas ER alpha increases PR.

<div class="cArrow"> </div><div class="cContentInner">ER alpha and ER beta have different effects on the uterus in this mice model. ER beta modulates ER alpha. ER beta decreases PR, whereas ER alpha increases PR.</div>

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Septic impairment of capillary blood flow requires NADPH oxidase but not NOS and is rap... - 0 views

www.ncbi.nlm.nih.gov/...PMC2572871

IV intravenous vitamin C BH4 tetrahydrobiopterine sepsis ascorbic acid

shared by Nathan Goodyear on 29 Feb 12 - No Cached

Nathan Goodyear on 29 Feb 12

IV vitamin C and BH4 shown to resolve blood flow restriction in Sepsis rat model. Again, revealing the benefits of not only vitamin C, but IV vitamin C.

<div class="cArrow"> </div><div class="cContentInner">IV vitamin C and BH4 shown to resolve blood flow restriction in Sepsis rat model. Again, revealing the benefits of not only vitamin C, but IV vitamin C.</div>

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Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 trans... - 0 views

www.ncbi.nlm.nih.gov/...PMC2725435

IV vitamin C brain Alzheimer's disease dementia cognition cognitive function learning

shared by Nathan Goodyear on 08 Mar 12 - No Cached

Nathan Goodyear on 08 Mar 12

IV vitamin C improves cognitive function in mice model.

<div class="cArrow"> </div><div class="cContentInner">IV vitamin C improves cognitive function in mice model. </div>

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Effect of supplementation of vi... [J Nutr Sci Vitaminol (Tokyo). 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11814146

vitamin C ascorbic acid Alzheimer's disease acetylcholine memory

shared by Nathan Goodyear on 08 Mar 12 - No Cached

Nathan Goodyear on 08 Mar 12

vitamin C inhibits acetylcholinesterase. This will increase acetylcholine and thus can play a role in Alzheimer's disease. People with Alzheimers disease have low levels of Vitamin C. Vitamin C shown to improve memory in Alzheimer's mouse model.

<div class="cArrow"> </div><div class="cContentInner">vitamin C inhibits acetylcholinesterase. This will increase acetylcholine and thus can play a role in Alzheimer's disease. People with Alzheimers disease have low levels of Vitamin C. Vitamin C shown to improve memory in Alzheimer's mouse model.</div>

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'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunc... - 0 views

jp.physoc.org/2485

HFCS high-fructose corn syrup n-3 omega-3 metabolic syndrome brain insulin MetS

shared by Nathan Goodyear on 16 May 12 - No Cached

Nathan Goodyear on 16 May 12

diets with high high-fructose corn syrup and low omega-3 shown to slow cognitive processing in rat model. This is basically, metabolic syndrome of the brain, as it is the result of hyperinsulinemia.

<div class="cArrow"> </div><div class="cContentInner">diets with high high-fructose corn syrup and low omega-3 shown to slow cognitive processing in rat model. This is basically, metabolic syndrome of the brain, as it is the result of hyperinsulinemia.</div>

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Antiinflammatory Effects of Estrogen on Microglial Activation - 0 views

endo.endojournals.org/...3646.long

Estradiol E2 neurodegenerative disease Parkinsons's Alzheimer's inflammation microglial glial cells hormones hormone estrogen

shared by Nathan Goodyear on 07 Jun 12 - No Cached

Nathan Goodyear on 07 Jun 12

Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease. this study looked at a rat model. The effect was not through inhibition of NF-kappaB, but through MAP kinase.

<div class="cArrow"> </div><div class="cContentInner">Estradiol (E2) shown to be neuroprotective in those with microglial excitotoxicity diseases, such as Parkinson's and Alzheimer's disease. this study looked at a rat model. The effect was not through inhibition of NF-kappaB, but through MAP kinase.</div>

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Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by alt... - 0 views

www.researchgate.net/...lance_among_CD4_T-cell_subsets

EGCG epigallocatechin-3-gallate autoimmune disease MS cytokine cytokines inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached

Nathan Goodyear on 22 Jan 14

EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis. Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.

<div class="cArrow"> </div><div class="cContentInner">EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis. Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.</div>

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Elevated androgens and prolactin in aromatase-... [Endocrinology. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11356695

prostate cancer hormone hormones androgens Testosterone DHT estrogens male men BPH

shared by Nathan Goodyear on 21 Jan 14 - No Cached

Nathan Goodyear on 21 Jan 14

aromatase knockout mice, thus elevated androgens without estrogen production, develop BPH but not prostate cancer. This points to estrogen as the important hormone in carcinogenesis of the prostate. Granted this is a animal model.

<div class="cArrow"> </div><div class="cContentInner">aromatase knockout mice, thus elevated androgens without estrogen production, develop BPH but not prostate cancer. This points to estrogen as the important hormone in carcinogenesis of the prostate. Granted this is a animal model.</div>

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20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits po... - 0 views

europepmc.org/...23295467

scleroderma vitamin D vitamin d inflammation autoimmune disease