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https://www.sightcare-co.com/ - 0 views

www.sightcare-co.com

sight care sightcare group training nearsightedness food for eyesight carey codd vitasight vision how to cure bad eye tips fix improve your red light eyes diet improvement skincare malaysia costos de medicare indonesia singapore eyecare

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
Nathan Goodyear

Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic P... - 0 views

atvb.ahajournals.org/...949

Copper iron arteriosclerosis metal plaques

shared by Nathan Goodyear on 06 Jul 11 - No Cached
  • Statistically elevated levels of iron were detected in the intima of lesions compared with healthy controls
  • Elevated levels of copper were also detected (7.51 versus 2.01 pmol/mg tissue, lesion versus healthy control, respectively
  • These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression
  • Nathan Goodyear on 06 Jul 11
     
    Iron and Copper accumulation in blood vessel wall may play role in diesease progression
Nathan Goodyear

Copper | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...copper

copper

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    good read on copper deficiency by the Linus Pauling Institute.
Nathan Goodyear

Aluminum and copper in drinking water enhance... [J Neuroimmunol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16697052

aluminum copper Al Cu brain inflammation oxidative water

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    Aluminum and Copper individually increase brain inflammation, but this study found synergistic effect on inflammation.  This test was in a mouse model using a 3 month introduction of contaminated water.
Nathan Goodyear

Copper deficiency after gastric surgery: a reason ... [Am J Med Sci. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19365170

deficiency copper gastric bypass

shared by Nathan Goodyear on 25 Jan 11 - No Cached
  • Nathan Goodyear on 25 Jan 11
     
    Copper deficiency present in gastric bypass patients: results in physiologic dysfunction in neurotransmitter synthesis
Nathan Goodyear

The role of copper in neurodegenerative disease. [Neurobiol Dis. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...10448050

Copper Alzheimer's disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    Copper imbalance contributes to development of Alzheimer's disease
Nathan Goodyear

Study of some biomarkers in hair of children with autism : Middle East Current Psychiatry - 0 views

journals.lww.com/...n_hair_of_children_with.2.aspx

Autism ASD Mercury Copper

shared by Nathan Goodyear on 19 May 11 - No Cached
  • positive correlation of CARS score with both mercury and copper,
  • Nathan Goodyear on 19 May 11
     
    positive correlation found between Mercury, Copper and Autism
Nathan Goodyear

High Fructose Feeding Induces Copper Deficiency in... [J Hepatol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21781943

fructose diet dietary Copper cu deficiency non-alcoholic fatty liver disease NAFLD

shared by Nathan Goodyear on 21 Oct 11 - No Cached
  • Nathan Goodyear on 21 Oct 11
     
    high Fructose dietary intake results in Copper deficiency.  Result is increase in non-alcoholic fatty liver.
Nathan Goodyear

Heart failure improvement from a supplement containing copper | European Heart Journal - 0 views

eurheartj.oxfordjournals.org/...117.1

heart failure copper cardiovascular disease cardiovascular disease

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    heart failure improved with copper supplementation.
Nathan Goodyear

Cardiovascular Disease from Copper Deficiency-A History - 0 views

jn.nutrition.org/...489.full.pdf+html

copper cardiovascular disease CVD heart disease cardiovascular disease

shared by Nathan Goodyear on 22 Dec 15 - No Cached
  • Nathan Goodyear on 22 Dec 15
     
    low copper associated with cardiac disease--particularly sudden death.
Nathan Goodyear

Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ra... - 0 views

acb.sagepub.com/...344.abstract

asthma selenium zinc copper glutathione hs-CRP TBARS FEV1 FVC catalase inflammation minerals

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • Nathan Goodyear on 07 Jul 16
     
    Asthma associated with low selenium, low zinc, high copper, low glutathione peroxidase, glutathione reductase, and catalase activity; in contrast, increased hs-CRP, and TBARS was  noted.  Interesting that FEV1 and FVC positively correlated with Se levels.
Nathan Goodyear

Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Defici... - 0 views

www.ncbi.nlm.nih.gov/...PMC3661234

superoxide disumutase SOD ADD ADHD attention deficit disorder copper

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    low SOD found to be associated with ADD/ADHD
Nathan Goodyear

Turning Tumor-Promoting Copper into an Anti-Cancer Weapon via High-Throughput Chemistry - 0 views

www.ncbi.nlm.nih.gov/...PMC3786439

copper cancer Cu Zn

shared by Nathan Goodyear on 06 Oct 21 - No Cached
  • Nathan Goodyear on 06 Oct 21
     
    Cu and cancer and means to lower
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic 
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
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