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Nathan Goodyear

The Cardiovascular Risk of Adult GH Deficiency (GHD) Improved after GH Replacement and ... - 0 views

jcem.endojournals.org/...1088.short

HGH IGF-1 deficiency human growth hormone CVD cardiac heart cardiovascular

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    in those adults with HGH deficiency, HGH replacement found to improve lipids, IGF-1, and cardiac function.
Nathan Goodyear

EHP - Competitive Androgen Receptor Antagonism as a Factor Determining the Pr... - 0 views

ehp.niehs.nih.gov/...1205391

pesticides androgen receptor antagonists testosterone AR male men

shared by Nathan Goodyear on 14 Nov 12 - No Cached
  • Nathan Goodyear on 14 Nov 12
     
    Many pesticides function as androgen receptor antagonists.  Others as Xenoestrogens.  Estrogen-like toxins and androgen receptor antagonists...a potent cocktail to disrupt male androgen signaling.
Nathan Goodyear

Update in TSH Receptor Agonists and Antagonists - 0 views

jcem.endojournals.org/...4287.abstract

receptors receptor thyroid TSHR

shared by Nathan Goodyear on 06 Dec 12 - No Cached
  • Nathan Goodyear on 06 Dec 12
     
    Just abstract is available to this just released article, but the opening sentence shows the importance of receptors: "the physiological role of the TSH receptor (TSHR) as a major regulator of thyroid functions is well understood..."
Nathan Goodyear

Vitamin D, Mitochondria, and Muscle - 0 views

jcem.endojournals.org/...961.full

vitamin vitamin d vitamins muscle phosphocreatine mitochondria

shared by Nathan Goodyear on 18 Mar 13 - No Cached
  • Nathan Goodyear on 18 Mar 13
     
    editorial discussion of the benefit of vitamin D in mitochondrial function.   Those in the vitamin D repletion arm of the study had a quicker recovery time to restored phospho-creatinine levels.  The quicker the recovery of phospho-creatinine levels, the shorter recovery phase and the likely improvement in athletic performance.
Nathan Goodyear

Androgens and penile erection: evidence for a direct relationship between free testoste... - 0 views

onlinelibrary.wiley.com/...abstract

ED testosterone men male

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    testosterone replacement in men found to improve penile blood flow and thus improve erectile function.
Nathan Goodyear

Effect of systemic vitamin C on free fatty ac... [Diabetes Metab. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15671911

vitamin C lipid peroxidation antioxidant vitamin

shared by Nathan Goodyear on 05 Jun 13 - No Cached
  • Nathan Goodyear on 05 Jun 13
     
    Vitamin C shown to improve endothelial function, but not shown to decrease lipid peroxidation marker.
Nathan Goodyear

Coronary Heart Disease in Smokers - 0 views

circ.ahajournals.org/...1233.full

IV vitamin C vitamin C IV vitamin C CHD coronary heart disease heart disease smokers

shared by Nathan Goodyear on 05 Jun 13 - No Cached
  • Nathan Goodyear on 05 Jun 13
     
    IV vitamin C shown to reduce pro oxidant effects of smoking and improved endothelial function.
Nathan Goodyear

Metabolic management of brain cancer - 0 views

www.sciencedirect.com/...S0005272810006857

brain cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Glutamine is a major metabolic fuel for both brain tumor cells and tumor-associated macrophages (TAMs)
  • the malignant phenotype of brain tumor cells that survive radiotherapy is often greater than that of the cells from the original tumor.
  • Conventional chemotherapy has faired little better than radiation therapy for the long-term management of malignant brain cancer
  • ...37 more annotations...
  • most conventional radiation and brain cancer chemotherapies can enhance glioma energy metabolism and invasive properties, which would contribute to tumor recurrence and reduced patient survival [34].
  • We contend that all cancer regardless of tissue or cellular origin is a disease of abnormal energy metabolism
  • complex disease phenotypes can be managed through self-organizing networks that display system wide dynamics involving oxidative and non-oxidative (substrate level) phosphorylation
  • As long as brain tumors are provided a physiological environment conducive for their energy needs they will survive; when this environment is restricted or abruptly changed they will either grow slower, growth arrest, or perish [8] and [19]
  • New information also suggests that ketones are toxic to some human tumor cells and that ketones and ketogenic diets might restrict availability of glutamine to tumor cells [68], [69] and [70].
  • The success in dealing with environmental stress and disease is therefore dependent on the integrated action of all cells in the organism
  • Tumor cells survive in hypoxic environments not because they have inherited genes making them more fit or adaptable than normal cells, but because they have damaged mitochondria and have thus acquired the ability to derive energy largely through substrate level phosphorylation
  • Cancer cells survive and multiply only in physiological environments that provide fuels (mostly glucose and glutamine) subserving their requirement for substrate level phosphorylation
  • Integrity of the inner mitochondrial membrane is necessary for ketone body metabolism since β-hydroxybutyrate dehydrogenase, which catalyzes the first step in the metabolism of β-OHB to acetoacetate, interacts with cardiolipin and other phospholipids in the inner membrane
  • the mitochondria of many gliomas and most tumors for that matter are dysfunctional
  • Cardiolipin is essential for efficient oxidative energy production and mitochondrial function
  • Any genetic or environmental alteration in the content or composition of cardiolipin will compromise energy production through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • the Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • the Crabtree effect can be reversible, the Warburg effect is largely irreversible because its origin is with permanently damaged mitochondria
  • The continued production of lactic acid in the presence of oxygen is the metabolic hallmark of most cancers and is referred to as aerobic glycolysis or the Warburg effect
  • We recently described how the retrograde signaling system could induce changes in oncogenes and tumor suppressor genes to facilitate tumor cell survival following mitochondrial damage [48].
  • In addition to glycolysis, glutamine can also increase ATP production under hypoxic conditions through substrate level phosphorylation in the TCA cycle after its metabolism to α-ketoglutarate
  • mitochondrial lipid abnormalities, which alter electron transport activities, can account in large part for the Warburg effect
  • targeting both glucose and glutamine metabolism could be effective for managing most cancers including brain cancer
  • The bulk of experimental evidence indicates that mitochondria are dysfunctional in tumors and incapable of generating sufficient ATP through oxidative phosphorylation
  • Cardiolipin defects in tumor cells are also associated with reduced activities of several enzymes of the mitochondrial electron transport chain making it unlikely that tumor cells with cardiolipin abnormalities can generate adequate energy through oxidative phosphorylation
  • The Crabtree effect involves the inhibition of respiration by high levels of glucose
  • Warburg effect involves elevated glycolysis from impaired oxidative phosphorylation
  • TCA cycle substrate level phosphorylation could therefore become another source of ATP production in tumor cells with impairments in oxidative phosphorylation
  • Caloric restriction, which lowers glucose and elevates ketone bodies [63] and [64], improves mitochondrial respiratory function and glutathione redox state in normal cells
  • DR naturally inhibits glycolysis and tumor growth by lowering circulating glucose levels, while at the same time, enhancing the health and vitality of normal cells and tissues through ketone body metabolism
  • DR is anti-angiogenic
  • DR also reduces angiogenesis in prostate and breast cancer
  • We suggest that apoptosis resistance arises largely from enhanced substrate level phosphorylation of tumor cells and to the genes associated with elevated glycolysis and glutaminolysis, e.g., c-Myc, Hif-1a, etc, which inhibit apoptosis
  • Modern medicine has not looked favorably on diet therapies for managing complex diseases especially when well-established procedures for acceptable clinical practice are available, regardless of how ineffective these procedures might be in managing the disease
  • More than 60 years of clinical research indicates that such approaches are largely ineffective in extending survival or improving quality of life
  • The process is rooted in the well-established scientific principle that tumor cells are largely dependent on substrate level phosphorylation for their survival and growth
  • Glucose and glutamine drive substrate level phosphorylation
  • targeting the glycolytically active tumor cells that produce pro-cachexia molecules, restricted diet therapies can potentially reduce tumor cachexia
  • It is important to recognize, however, that “more is not better” with respect to the ketogenic diet
  • Blood glucose ranges between 3.0 and 3.5 mM (55–65 mg/dl) and β-OHB ranges between 4 and 7 mM should be effective for tumor management
  • Nathan Goodyear on 17 Jun 13
     
    Dr Seyfriend presents his metabolic approach to the treatment of brain cancer.
Nathan Goodyear

Cell Metabolism - The Ubiquitin Ligase Mul1 Induces Mitophagy in Skeletal Muscle in Res... - 0 views

www.cell.com/...S1550413112004056

muscle wasting mitochondria energy metabolism

shared by Nathan Goodyear on 02 Jan 13 - No Cached
  • Nathan Goodyear on 02 Jan 13
     
    loss of mitochondria leads to muscle wasting.  Kind of makes sense.  The muscles lose the ability to make energy and thus the muscle cells die and waste.  Thus, preserve mitochondrial function and you will slow muscle wasting.
Nathan Goodyear

Salivary cortisol monitoring: de... [Allergy Asthma Proc. 2012 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22856637

saliva salivary cortisol testing hormone hormones

shared by Nathan Goodyear on 04 Jan 13 - No Cached
  • Nathan Goodyear on 04 Jan 13
     
    This study found salivary cortisol testing is a better technique for children, in evaluating HPA axis function in children with asthma.
Nathan Goodyear

Testosterone: a vascular hormone in health and disease - 0 views

joe.endocrinology-journals.org/...JOE-12-0582.full.pdf+html

low T low Testosterone testosterone low cardiovascular cardiovascular disease CVD health hormone hormones men male

shared by Nathan Goodyear on 23 Apr 13 - No Cached
  • Nathan Goodyear on 23 Apr 13
     
    testosterone therapy has tremendous cardiovascular benefit in men with low T.  The key here is physiologic replacement of Testosterone.  Testosterone is a vasodilator and anti-inflammatory agent in men with low T.  Testosterone therapy improves cardiac function in those with DHF and angina.  Testosterone is found to be a Ca++ channel blocker--anyone say hypertension treatment?
Nathan Goodyear

3alpha-androstanediol, but not testoste... [Front Aging Neurosci. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20552051

3-alpha androstanediol testosterone metabolite metabolites hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • Nathan Goodyear on 30 Apr 13
     
    Now, this is a rat model, but 3 alpha androstanediol treatment restored cognitive function  greater than testosterone alone.
Nathan Goodyear

International Journal of Obesity - Late-life obesity is associated with smaller global ... - 0 views

www.nature.com/...ijo201213a.html

obesity overweight brain CNS

shared by Nathan Goodyear on 29 Jan 13 - No Cached
  • Nathan Goodyear on 29 Jan 13
     
    Need your brain at its peak performance?  Better lose weight if you are overweight.  Studies show a reduced brain volume and decreased cognitive function in those that are overweight.
Nathan Goodyear

Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older W... - 0 views

biomedgerontology.oxfordjournals.org/...1092.abstract

vitamin D cognitive decline cognitive decline memory women vitamin

shared by Nathan Goodyear on 12 Feb 13 - No Cached
  • Nathan Goodyear on 12 Feb 13
     
    Just an association, but low vitamin  D levels found to be associated with decreased cognitive function in older women.  Found in women with levels < 20.
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

ajcn.nutrition.org/...268.abstract

CHF congestive heart failure CoQ10 heart failure

shared by Nathan Goodyear on 25 Jan 13 - No Cached
  • Nathan Goodyear on 25 Jan 13
     
    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
Nathan Goodyear

Effect of a low-carbohydrate diet on appetite... [Ann Intern Med. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15767618

low carb low carbohydrate diet low carbohydrate glucose insulin type II diabetes diabetes DM

shared by Nathan Goodyear on 08 Feb 13 - Cached
  • Nathan Goodyear on 08 Feb 13
     
    low carbohydrate diet found to improve glucose and insulin function in those obese with type II diabetes
Nathan Goodyear

Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease - 0 views

www.chinaphar.com/...391.pdf

Huperzine-A memory cognition Alzheimer's Alzheimer's disease acetylcholinesterase inhibitor

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    small study, but well designed that showed that huperzine A supplementation improved executive function in Alzheimer's patients. Huperzine A is an acetylcholinesterase inhibitor.
Nathan Goodyear

Pesticide-induced decrease in rat tes... [Ecotoxicol Environ Saf. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23465731

Pesticides pesticide xenoestrogen xenoestrogens alpha lipoic acid ALA tocopherols

shared by Nathan Goodyear on 04 Jul 13 - No Cached
  • Nathan Goodyear on 04 Jul 13
     
    Pesticides disrupt the testicular function, in part, through oxidative damage.  This study found Alpha lipoic acid  to be a promising, effective mechanism to reduce the oxidative stress.  They also found tocopherols to be effect, but to a lesser extent.
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor p43 Induces a Shift in Skelet... - 0 views

www.plosone.org/...journal.pone.0002501

mitochondria T3 thyroid hormone hormones muscle PPAR-gamma PPAR PGC1-alpha

shared by Nathan Goodyear on 29 Jun 13 - No Cached
  • Nathan Goodyear on 29 Jun 13
     
    T3 induces beneficial oxidative changes in muscles through its interaction with mitochondrial receptors.  PGC-1alpha and PPAR-gamma were involved in this process.  The important point here is that T3 is increasing oxidative function of muscle through interaction with mitochondria.
Nathan Goodyear

Minireview: Inflammation and Obesity Pathogenesis: The Hypothalamus Heats Up - 0 views

endo.endojournals.org/...4109.full

inflammation obesity overweight hypothalamus HPA

shared by Nathan Goodyear on 04 Oct 12 - No Cached
  • Leptin, secreted by adipocytes in proportion to body fat mass
  • The saturated fatty acid palmitate (16:0) induces NF-κB signaling through a TLR4-dependent mechanism
  • 18:0 (stearic) and longer saturated fatty acids as well as linolenic acid (18:3) increased proinflammatory cytokines, ER stress markers, and TLR4 activation
  • ...6 more annotations...
  • (SOCS)-3. A member of a protein family originally characterized as negative feedback regulators of inflammation (13, 37), SOCS3 inhibits insulin and leptin signaling
  • IKKβ signaling in discrete neuronal subsets appears to be required for both hypothalamic inflammation and excess weight gain to occur during HF feeding
  • the paradoxical observation that hyperphagia and weight gain occur when hypothalamic inflammation is induced by HF feeding, yet when it occurs in response to systemic or local inflammatory processes (e.g. administration of endotoxin), anorexia and weight loss are the rule
  • , serves as a circulating signal of energy stores in part by providing feedback inhibition of hypothalamic orexigenic pathways [e.g. neurons that express neuropeptide Y and agouti-related peptide (AgRP)]
  • and stimulating anorexigenic neurons
  • signals from Toll-like receptors (TLRs), evolutionarily conserved pattern recognition molecules critical for detecting pathogens, amplified through signaling intermediates such as MyD88 activate the inhibitor of κB-kinase-β (IKKβ)/nuclear factor-κB (NF-κB), c-Jun N-terminal kinase (Jnk) and other intracellular inflammatory signals in response to stimulation by circulating saturated fatty acids
  • Nathan Goodyear on 04 Oct 12
     
    great read on the current understanding of how obesity and resultant inflammation disrupts hypothalamic function.
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