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increased estradiol and estrone levels in men associated with cognitive decline.  This was distinct from age, CVD, and APOE genotype.  This points to a clear association between increased aromatase activity and inflammation that contributes to cognitive decline in men.

Just the abstract here.  Declining estradiol production found to be associated with increased cognitive dysfunction or cognitive decline in those using aromatase inhibitor therapy.  Aromatase inhibition therapy is used to block Testosterone to Estradiol production in women with ER+ breast cancer.

Untold risk of early ovary removal appears to be cognitive decline and increased risk of dementia.  The earlier the age of removal, the more the increased risk of cognitive decline.  

Statin use found to be associated with cognitive decline.  The authors defined use as long-term, though 2 years of use was found to be associated with decline.   interestingly, metabolic syndrome was not found to be associated with cognitive decline.

New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.

Study finds suggestion of cognitive protection by enduring estrogen exposure.  Interesting, that estrogen seems to protect against cognitive decline in women, yet increases cognitive decline in men.

Postmenopausal cognitive decline is a common complaint.  Declining Estradiol and progesterone have been implicated, in part, to this cognitive decline.  This study finds that progesterone increases expression of Transthyretin, a protein that processes amyloid Beta protein.  This amyloid Beta protein is associated with damage found in Alzheimer's. 

Mediterranean diet found to improve cognition and slow progression and/or risk of Alzheimer's disease.

This was the WHI review of data as it pertains to dementia and cognitive decline in women.  The take home here is that the data provides little evidence for premarin with or without medroxyprogesterone acetate in > 65 for prevention of dementia.  However, this is in women > 65 and studies show that younger women do indeed receive benefit, especially in those with early ovary removal.  Another point here, MPA (medroxyprogesterone acetate) increases cognitive decline.  Just don't take MPA, it is a bad drug all the way around!

Article links Fructose, to obesity and cognitive decline.

Meta-analysis of 21 studies on acetyl Carnitine finds improvement with mild cognitive impairment and/or prevention of cognitive deterioration.

small study finds limited improvement in cognition in men with low T and mild Cognitive impairment.  Little application from this study.

This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.

low T appears to be associated with cognitive decline in men.  If low T is present on testing, then therapy is appropriate to improve cognition.

review finds Mediterranean diet associated with improved cognitive function and possible delay in cognitive decline.

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Just an association, but low vitamin  D levels found to be associated with decreased cognitive function in older women.  Found in women with levels < 20.

High salivary cortisol and decrease metabolism of cortisol (urinary) is associated with increased cognitive decline in the elderly.

Medical dogma tells us that menopause is simply an estrogen deficiency.  This new study points to correlation between progesterone decline and cognitive decline in menopausal women.

Study describes the link between fructose, obesity and cognitive decline.