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Nathan Goodyear

Homocysteine and MTHFR Mutations - 0 views

circ.ahajournals.org/...e289.full

homocysteine MTHFR CVD cardiovascular death CAD c677T A1298c

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • The most common MTHFR mutation is called the MTHFR C677T mutation
  • Another common mutation is called MTHFR A1298C
  • Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation)
  • ...4 more annotations...
  • Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
  • Regardless of whether you have an MTHFR mutation in both genes or not, the treatment for elevated homocysteine is the same—dietary intervention and supplementation with folic acid and vitamins B6 and B12
  • Overall, evidence from these studies indicates that, so long as the homocysteine level is normal, MTHFR mutations do not significantly increase the risk of heart attack or stroke
  • Studies investigating the association of MTHFR mutations and venous blood clots have been inconsistent, with some studies showing a slight association, but most studies have not shown any association
  • Nathan Goodyear on 02 Feb 15
     
    Good review of MTHFR and homocysteine.
Nathan Goodyear

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide... - 0 views

circ.ahajournals.org/...1193.long

BH4 5-methyltetrahydrofolate tetrahydrobiopterine MTHFR MTHFR A1298C eNOS NO nitric oxide atherosclerosis cardiovascular disease CVD

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis.  Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.
Nathan Goodyear

MTHFR C677T polymorphism associates with unexplained infertile male factors | SpringerLink - 0 views

link.springer.com/...s10815-005-6795-0

MTHFR C677T infertility male infertility epigenetics

shared by Nathan Goodyear on 19 Sep 17 - No Cached
  • Nathan Goodyear on 19 Sep 17
     
    The title is just as it says. No infertility was noted with MTHFR A1298C.
Nathan Goodyear

Folate | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...folate

Folate folic acid MTHFR micronutrients

shared by Nathan Goodyear on 23 Aug 15 - No Cached
  • Nathan Goodyear on 23 Aug 15
     
    Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.
Nathan Goodyear

IJMS | Free Full-Text | Defective Homocysteine Metabolism: Potential Implications for S... - 0 views

www.mdpi.com/...htm

homocysteine MTHFR

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    very nice review of homocysteine pathways.
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