Skip to main content

Home/ Dr. Goodyear/ Group items tagged micronutrients

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Quantitative data on the magnitude of the systemic inflammatory response and its effect... - 0 views

www.ajcn.org/...64.abstract

inflammation micronutrients Vitamin A B-6 C D

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    As systemic inflammation goes up: the reliability of plasma micronutrients goes down.  The micronutrients listed in this study (Se, A, B-6, C and D) decreased as inflammation increased.  The take home is, the reliability of micronutrient testing must take into account inflammation
Nathan Goodyear

Nutrition Journal | Full text | Micronutrient deficiency in obese subjects undergoing l... - 0 views

www.nutritionj.com/...34

micronutrient deficiencies obesity.

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Nathan Goodyear on 31 Aug 12
     
    micronutrient deficiencies found to be common in obese individuals.  And it stands to reason, that amino acid (protein) shakes do nothing to correct this.
Nathan Goodyear

Parenteral Micronutrient Therapy (June 2008) Townsend Letter for Doctors & Patients - 0 views

www.townsendletter.com/...clinical0608.htm

IV therapy micronutrient parenteral

shared by Nathan Goodyear on 02 Nov 12 - No Cached
  • Nathan Goodyear on 02 Nov 12
     
    pro's/con's of IV therapy.
fitspresso

LeanBiome™ (Official) | Get Save UpTo $540 Today Only! - 0 views

usleanbiome.com

leanbiome us lean biome usa uk buy get does work discount 2022 australia legit weight loss bioma customer reviews review canada website ireland product

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    LeanBiome™ (Official) | Get Save UpTo $540 Today Only! usleanbiome.com LeanBiome™ Hurry Up! Offer Expires in: 00 HOUR 29 MINUTE 59 SECOND LeanBiome Attention! Get Special 84% Discount Today Faster fat burning and weight loss Healthy cholesterol and sugar levels Higher energy levels Regular price: $129 Only for: 39$ What Is LeanBiome? LeanBiome Lean for Good is a weight loss dietary supplement derived from scientifically researched ingredients and comprehensively developed to help people achieve sustainable weight control. The formula comes in a capsule format that is easy to take and is made with natural ingredients from plants and other sources to achieve its goals. The main ingredient in LeanBiome is piperine, which has been found to affect the body's ability to absorb micronutrients and other compounds more effectively. LeanBiome is a dietary supplement that claims to help weight management. It contains 100% natural ingredients that support healthy weight loss. It does not interfere with any natural process making it safe for use. It ranks among the top weight loss supplements that claim to provide a permanent solution. LeanBiome is made by a company named Lean for Good. It is made with natural and research-backed ingredients that help you lose excess fat without hassles. It is sold in capsule form. The company assures the composition is GMO, gluten, and soy-free. As for manufacturing standards, you need not fret. The company makes the supplement in a facility certified by the FDA. How Does LeanBiome Work? The starting period of the LeanBiome program includes a detoxification process that effectively removes any accumulated ree radicals, toxins, fand oxidative stress. This cleansing enables improved blood circulation, setting the stage for the body to initiate its own fat-burning mechanisms. To enhance metabolic activity, introducing the lean bacteria contained in LeanBiome to your gut microbiome is a beneficial approach. This activation triggers r
Nathan Goodyear

Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and... - 0 views

ajcn.nutrition.org/...136.abstract

blood pressure glycine amino acids

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    This study links glycine to increased blood pressure.  However, meat is the primary source of glycine. So, if the meat is loaded with omega-6, hormones...these will be the source of the inflammation and resultant increase in blood pressure, not the glycine.  One must read these studies closely.  No conclusion can be made from this study.
Nathan Goodyear

Folate | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...folate

Folate folic acid MTHFR micronutrients

shared by Nathan Goodyear on 23 Aug 15 - No Cached
  • Nathan Goodyear on 23 Aug 15
     
    Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.
Nathan Goodyear

Dietary Fiber - 0 views

advances.nutrition.org/...151.full

dietary fiber

shared by Nathan Goodyear on 28 Apr 11 - No Cached
  • decreased risk of coronary heart disease with dietary fiber consumption
  • Good sources of dietary fiber include whole grains, legumes, vegetables, nuts and seeds, and fruits
  • most experts recommend that fiber should be obtained through the consumption of foods, because this form allows consumption of many micronutrients and bioactive compounds contained in high-fiber foods, which provide their own nutritional benefits.
  • ...2 more annotations...
  • increase in the consumption of foods containing fiber to reduce obesity, cardiovascular disease, type 2 diabetes, and some cancers.
  • One of the products of fermentation, butyrate, is able to regulate gene transcription through its actions as a histone deacetylase inhibitor, which affects cell proliferation, differentiation, and apoptosis of colon cells
  • Nathan Goodyear on 28 Apr 11
     
    Great short review on Fiber and health benefits
Nathan Goodyear

Oncotarget | Vitamin C and Doxycycline: A synthetic lethal combination therapy targetin... - 0 views

www.impactjournals.com/...index.php

cancer doxycycline IV vitamin C vitamin C

shared by Nathan Goodyear on 14 Jun 17 - No Cached
  • These eight distinct cancer types included: DCIS, breast (ER(+) and ER(-)), ovarian, prostate, lung, and pancreatic carcinomas, as well as melanoma and glioblastoma. Doxycycline was also effective in halting the propagation of primary cultures of CSCs from breast cancer patients, with advanced metastatic disease (isolated from ascites fluid and/or pleural effusions)
  • Doxycycline behaves as a strong radio-sensitizer, successfully overcoming radio-resistance in breast CSCs
  • cancer cells can indeed escape the effects of Doxycycline, by reverting to a purely glycolytic phenotype. Fortunately, the metabolic inflexibility conferred by this escape mechanism allows Doxycycline-resistant (DoxyR) CSCs to be more effectively targeted with many other metabolic inhibitors, including Vitamin C, which functionally blocks aerobic glycolysis
  • ...36 more annotations...
  • Vitamin C inhibits GAPDH (a glycolytic enzyme) and depletes the cellular pool of glutathione, resulting in high ROS production and oxidative stress
  • DoxyR CSCs are between 4- to 10-fold more susceptible to the effects of Vitamin C
  • Doxycycline and Vitamin C may represent a new synthetic lethal drug combination for eradicating CSCs, by ultimately targeting both mitochondrial and glycolytic metabolism
  • inhibiting their propagation in the range of 100 to 250 µM
  • metabolic flexibility in cancer cells allows them to escape therapeutic eradication, leading to chemo- and radio-resistance
  • used doxycycline to pharmacologically induce metabolic inflexibility in CSCs, by chronically inhibiting mitochondrial biogenesis
  • This treatment resulted in a purely glycolytic population of surviving cancer cells
  • DoxyR cells are mainly glycolytic
  • MCF7 cells survive and develop Doxycycline-resistance, by adopting a purely glycolytic phenotype
  • Cancer stem cells (CSCs) are thought to be the “root cause” of tumor recurrence, distant metastasis and therapy-resistance
  • the conserved evolutionary similarities between aerobic bacteria and mitochondria, certain classes of antibiotics inhibit mitochondrial protein translation, as an off-target side-effect
  • Vitamin C was more potent than 2-DG; it inhibited DoxyR CSC propagation by > 90% at 250 µM and 100% at 500 µM
  • IC-50
  • DoxyR CSCs are between 4- to 10-fold more sensitive to Vitamin C than control MCF7 CSCs
  • Berberine, which is a naturally occurring antibiotic that also behaves as an OXPHOS inhibitor
  • treatment with Berberine effectively inhibited the propagation of the DoxyR CSCs by > 50% at 1 µM and > 80% at 10 µM.
  • Doxycycline, a clinically approved antibiotic, induces metabolic stress in cancer cells. This allows the remaining cancer cells to be synchronized towards a purely glycolytic phenotype, driving a form of metabolic inflexibility
  • Doxycycline-driven aerobic glycolysis
  • new synthetic lethal strategy for eradicating CSCs, by employing i) Doxycycline (to target mitochondria) and ii) Vitamin C (to target glycolysis)
  • Doxycycline inhibits mitochondrial biogenesis and OXPHOS,
  • hibits glycolytic metabolism by targeting and inhibiting the enzyme GAPDH
  • CSCs act as the main promoter of tumor recurrence and patient relapse
  • a metabolic shift from oxidative to glycolytic metabolism represents an escape mechanism for breast cancer cells chronically-treated with a mitochondrial stressor like Doxycycline, as mitochondrial dys-function leads to a stronger dependence on glucose
  • Vitamin C has been demonstrated to selectively kill cancer cells in vitro and to inhibit tumor growth in experimental mouse models
  • many of these actions have been attributed to the ability of Vitamin C to act as a glycolysis inhibitor, by targeting GAPDH and depleting the NAD pool
  • here we show that DoxyR CSCs are more vulnerable to the inhibitory effects of Vitamin C, at 4- to 10-fold lower concentrations, between 100 to 250 μM
  • concurrent use of Vitamin C, with standard chemotherapy, reduces tumor recurrence and patient mortality
  • after oral administration, Vitamin C plasma levels reach concentrations of ~70-220 μM
  • intravenous administration results in 30- to 70- fold higher plasma concentrations of Vitamin C
  • pro-oxidant activity results from Vitamin C’s action on metal ions, which generates free radicals and hydrogen peroxide, and is associated with cell toxicity
  • it has been shown that high-dose Vitamin C is more cytotoxic to cancer cells than to normal cells
  • This selectivity appears to be due to the higher catalase content observed in normal cells (~10-100 fold greater), as compared to tumor cells. Hence, Vitamin C may be regarded as a safe agent that selectively targets cancer cells
  • the concurrent use of Doxycycline and Vitamin C, in the context of this infectious disease, appeared to be highly synergistic in patients
  • Goc et al., 2016, showed that Doxycycline is synergistic in vitro with certain phytochemicals and micronutrients, including Vitamin C, in the in vitro killing of the vegetative spirochete form of Borrelia spp., the causative agent underlying Lyme disease
  • Doxycycline, an FDA-approved antibiotic, behaves as an inhibitor of mitochondrial protein translation
  • CSCs successfully escape from the anti-mitochondrial effects of Doxycycline, by assuming a purely glycolytic phenotype. Therefore, DoxyR CSCs are then more susceptible to other metabolic perturbations, because of their metabolic inflexibility
  • Nathan Goodyear on 14 Jun 17
     
    Not especially new, but IV vitamin C + daily doxycycline found to kill cancer stem cells.
Nathan Goodyear

Cooperation of Doxycycline with Phytochemicals and Micronutrients Against Active and Pe... - 0 views

www.ncbi.nlm.nih.gov/...PMC4997053

Lyme Lyme disease vitamin C vitamin D doxycycline natural therapies

shared by Nathan Goodyear on 07 Jul 17 - No Cached
  • Nathan Goodyear on 07 Jul 17
     
    nice study that looked at natural therapies i.e. vitamin C, vitamin D... coupled with doxycycline in treating the bacteria Borrelia that is the cause of Lyme.
1 - 11 of 11
Showing 20▼ items per page