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wheelchairindia9

Cervical Collar Soft Firm Density - 0 views

www.wheelchairindia.com/...vical-Collar-Soft-Firm-Density

Cervical Collar Soft Firm Density tynor firm density soft cervical collar tynor cervical collar soft firm density collar soft firm density soft collar firm density soft cervical collar firm density

shared by wheelchairindia9 on 21 Mar 16 - No Cached
  • wheelchairindia9 on 21 Mar 16
     
    Cervical Collar Soft Firm Density Cervical Collar Soft (Firm Density) is used for supporting, immobilizing or adjusting the neck in the flexion, extension, or hyperextension position. Recommended where a partial or controlled immobilization of the cervical region is required. Ultimate comfort Effective immobilization Strong support Excellent aesthetics Long life. Cervical Collar Soft Firm Density Features Made of very high density (60 kg./m3) P.U. foam High immobilization, better support , quick relief, no reinforcement, more comfortable, long life. Anatomical design Uniform support to the mandible, Better immobilization, Better comfort Covered with hypoallergenic cotton stockinet Better patient comfort, no allergy or rash even to sensitive skin. Better compliance Perforated collar body Improved ventilation , more patient comfort, better compliance. Fawn colored stockinette Matches skin color, Better aesthetics. Long hook-loop closure tape Ensure snug fitting around neck, easy application and quick removal.
Nathan Goodyear

Plasma lipoproteins: composition, structure and biochemistry - 0 views

lipidlibrary.aocs.org/...index.htm

apolipoproteins cholesterol VLDL chylomicrons LDL HDL lipoproteins biochemistry

shared by Nathan Goodyear on 21 May 13 - No Cached
  • triacylglycerols
  • The most abundant lipid constituents are triacylglycerols, free cholesterol, cholesterol esters and phospholipids (phosphatidylcholine and sphingomyelin especially ), though fat-soluble vitamins and anti-oxidants are also transported in this way
  • the lipoprotein aggregates should be described in terms of the different protein components or apoproteins (or 'apolipoproteins'
  • ...8 more annotations...
  • Density is determined largely by the relative concentrations of triacylglycerols and proteins and by the diameters of the broadly spherical particles
  • these classes can be further refined by improved separation procedures, and intermediate-density lipoproteins (IDL) and subdivisions of the HDL (e.g. HDL1, HDL2, HDL3 and so forth
  • the main groups are classified as chylomicrons (CM), very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), based on the relative densities of the aggregates on ultracentrifugation
  • the various lipid components should not be considered as absolute, as they are in a state of constant flux
  • Apo A1 is the main protein component of HDL
  • Apo A2 is the second most important HDL apolipoprotein
  • Lipoproteins are spherical (VLDL, LDL, HDL) to discoidal (nascent HDL) in shape with a core of non-polar lipids, triacylglycerols and cholesterol esters, and a surface monolayer, ~20Å thick, consisting of apoproteins, phospholipids and non-esterified cholesterol, which serves to present a hydrophobic face to the aqueous phase
  • The lipoproteins can be categorised simplistically according to their two main metabolic functions. The principal role of the chylomicrons and VLDL is to transport triacylglycerols ‘forward’ as a source of fatty acids from the intestines or liver to the peripheral tissues. In contrast, the HDL remove excess cholesterol from peripheral tissues and deliver it to the liver for excretion in bile in the form of bile acids (‘reverse cholesterol transport’). While these functions are considered separately here for convenience, it should be recognised that the processes are highly complex and inter-related, and they involve transfer of apoproteins, enzymes and lipid constituents among the heterogeneous mix of all the lipoprotein fractions.
  • Nathan Goodyear on 21 May 13
     
    Awesome review of apolipoproteins, their function, and their metabolism.
Nathan Goodyear

Understanding lipoproteins as transporters of cholesterol and other lipids - 0 views

advan.physiology.org/...105.full

lipoproteins apolipoproteins cholesterol atherosclerosis CVD CAD

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • the density of each lipoprotein is clearly in a constant state of flux
  • Two lipoprotein fractions are primarily involved in transport of lipid to peripheral tissues, very low density lipoproteins (VLDL) from the liver and chylomicrons from the intestinal tract
  • As lipid is removed from these two fractions, the density of each fraction increases, thereby transforming VLDL into intermediate-density lipoprotein (IDL) and ultimately LDL, and chylomicrons into chylomicron remnants
  • ...5 more annotations...
  • LDL-cholesterol has been described, and overly simplified, as “bad cholesterol” and HDL-cholesterol as “good cholesterol.”
  • HDL, is primarily involved in returning lipid, largely cholesterol, to the liver in a process called reverse cholesterol transport
  • Two primary subfractions of HDL have been classified as the higher-density HDL3, and the less dense, more lipid-filled HDL2
  • Recent investigations are also suggesting that smaller, denser lipoproteins are associated with increased risk of atherosclerotic development
  • lipoproteins as transporters of lipid
  • Nathan Goodyear on 03 Jul 13
     
    Brief, but good review of lipoproteins and apoliproteins.
Nathan Goodyear

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Me... - 0 views

press.endocrine.org/...jcem.86.2.7219

low t low Testosterone Testosterone SHBG FAI free androgen index male hormone hormones aging obesity

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • NUMEROUS CROSS-SECTIONAL INVESTIGATIONS have demonstrated lower concentrations of circulating testosterone (T) and/or free T in older men
  • Two small-scale longitudinal investigations have observed decreases, with aging, in total T
  • T levels decline at a more or less constant rate, with age, in men, with no period of accelerated decline
  • ...15 more annotations...
  • aging in men is associated with decreases in bone mineral density (BMD) (18, 19), lean body and muscle mass
  • strength (22, 23) and aerobic capacity (24), as well as with increases in total and abdominal body fat, low-density lipoprotein cholesterol, and/or low-density lipoprotein/high-density lipoprotein cholesterol ratios (25, 26, 27, 28), all of which also occur in nonelderly hypogonadal men
  • Most (1, 5, 6, 7, 8, 9), but not all (10, 11, 12), cross-sectional studies have demonstrated a decrease, with age, in total T in men
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      FAI: 100 x total Testosterone nmol/L/SHBG nmol/L
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      These numbers do point to an increase in ng/dl decline in Total Testosterone with increasing age (decade group)
  • total T, but not free T index, tended to decrease with greater BMI is consistent with prior studies showing that obesity is associated with decreases in both SHBG and total T, with an unchanged T-to-SHBG ratio
  • The conventional definition for T levels is statistical (values more than 2 sd below the mean), rather than functional. Such a definition does not reflect clinical realities, such as the existence of characteristic individual set points for circulating hormone levels, below which one, but not another, individual may develop metabolic changes of hormone deficiency; nor does it address the concept of reserve capacity, the possibility that persons with hormone levels 2 sd below the population mean still may have adequate hormone concentrations to meet their metabolic needs.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      good explanation of problems with just using a number to define low T
  • both T and free T index (a calculated value related to free or bioavailable T) decreased progressively at a rate that did not vary significantly with age, from the third to the ninth decades.
  • contrasts with other studies showing diminished free, as well as total, T in with increasing total (48) or abdominal (49) obesity in men.
  • Our analysis of date-adjusted T and free T index levels, by decade, showed that relatively high numbers of older men in this generally healthy population had at least one hypogonadal value (defined as below the 2.5th percentile for young men)
  • The issue of how properly to define hypogonadism, or indeed any hormone deficiency, remains problematic
  • The decrease in free T index was somewhat steeper than that of total T, owing to a trend for an increase in SHBG with age
  • LH for gonadal function
  • It would clearly be better to define the lower limit of normal for a hormone as: the blood level at which metabolic and/or clinical sequelae of hormone deficiency begin to appear, or the level below which definite benefits can be demonstrated for hormone supplementation for a significant proportion of the population
  • an effect of aging to lower both total and bioavailable circulating T levels at a relatively constant rate, independent of obesity, illness, medications, cigarette smoking, or alcohol intake
  • Nathan Goodyear on 30 Mar 15
     
    Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.
Nathan Goodyear

Breast Cancer Research | Full text | Circulating serum xenoestrogens and mammographic b... - 0 views

breast-cancer-research.com/...R45

xenoestrogens BPA phthalates women breast cancer

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    study finds increased BPA and phthalates in women is associated with increased breast density.
Nathan Goodyear

High aromatase activity in hypogonadal men is associated with higher spine bone mineral... - 0 views

www.ncbi.nlm.nih.gov/...26142101

aromatase activity hypogonadal men low T low Testosterone fat obesity obese lean body mass muscle BMD men male hormoens

shared by Nathan Goodyear on 06 Jul 15 - No Cached
  • Nathan Goodyear on 06 Jul 15
     
    Only abstract available here--high Estradiol:Testosterone, thus high aromatase activity, increased abdominal fat and reduced lean muscle mass.  The authors also reported an higher bone mineral density, but that pales in the comparison of the metabolic dysfunction of high fat and low muscle mass causes.
Nathan Goodyear

High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Fa... - 0 views

www.ncbi.nlm.nih.gov/...PMC4344236

prostate cancer progesterone progesterone receptor hormones cancer prostate

shared by Nathan Goodyear on 03 Jun 18 - No Cached
  • Currently, there is a general agreement of PGR presence in the stromal cells of PCa
  • expressed in both stromal and tumor cells of the PCa tissue
  • In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
  • ...17 more annotations...
  • High density level of PGR in the TE was an independent prognostic factor for CF.
  • Our large-sized study demonstrates a wide distribution of PGR in stromal and epithelial cells of both benign and malignant prostate tissue
  • there seems to be a general agreement of PGR presence in the stromal cells of PCa
  • In line with our findings, several have also reported a high PGR expression in TE of PCa [9,10,23,25]. In contrast, others have demonstrated a total lack of PGR expression in TE
  • the actions of progesterone are tissue specific
  • In our work univariate analysis demonstrated a high PGR expression in TS to be associated with clinical failure in PCa patients. So far we have not yet demonstrated the mechanism underlying this association
  • Several non-genomic proliferative actions of progesterone have been proposed in tumor cells of other organs, including breast [35–37], astrocytoma [38] and osteosarcoma [39] cell lines. However, such results are contradicted by suggestions of anti-proliferative actions of progesterone in endometrial cancer
  • Yu et al. found PGR to be negatively regulating stromal cell proliferation in vitro
  • high PGR density level in TE was associated with CF in patients with Gleason score ≥ 7
  • Bonkhoff et al. have suggested progressive emergence of PGR during PCa progression and metastasis
  • Latil and co-workers found a decreased PGR expression in clinically localized tumors and increased PGR expression in hormone-refractory tumors, when compared with normal prostate tissue
  • Our findings provide further support to these findings, indicating that PGR plays a role in the pathogenesis of PCa
  • Ki67 and PGR in TE were correlated with CF (S3 Text), indicating an association between PGR and proliferative activity
  • The mechanism behind the PGR up-regulation in PCa has not yet been elucidated
  • The PGR is, like the glucocorticoid receptor, similar to androgen receptor with 88% sequence homology in the ligand-binding domain
  • progesterone induced expression of androgen receptor-regulated genes could be a potential mechanism contributing to the development of castrate resistant PCa
  • A possibility of different roles by the two PGR isoforms in normal prostate tissue and PCa, as is suggested for the estrogen receptors [13], must also be taken into account
  • Nathan Goodyear on 03 Jun 18
     
    STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy.  Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.
Nathan Goodyear

Comparison of Sex Steroid Measurements in Men by Immunoassay versus Mass Spectroscopy a... - 0 views

www.ncbi.nlm.nih.gov/...PMC2636568

MS mass spectroscopy immunoassay hormone hormones measurement measurements bone mineral density

shared by Nathan Goodyear on 24 Jun 12 - No Cached
  • Nathan Goodyear on 24 Jun 12
     
    Mass Spectroscopy proves to be better test, specifically specificity, in men due to low Estradiol levels.  This study compared MS to Immunoassay.
Nathan Goodyear

Review of health risks of low testosterone and testosterone administration - 0 views

www.ncbi.nlm.nih.gov/...PMC4391003

low Testosterone low T Testosterone men male hormone hormones health

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • Hypogonadism may be defined either as serum concentration of T (either total T, bioavailable T or free T) or as low T plus symptoms of hypogonadism
  • The Baltimore Longitudinal Study on Aging reported the incidence of total serum T < 325 ng/dL to be 20% for men in their 60s, 30% for men in their 70s and 50% for men over 80
  • The Massachusetts Aging Male Study reported that 12.3% of men aged 40 to 70 had a total serum T of < 200 ng/dL with 3 or more symptoms of hypogonadism
  • ...19 more annotations...
  • The Boston Area Community Health Study reported that 5.6% of men aged 30 to 70 were hypogonadal, as defined by total serum T < 300 ng/dL; or, free serum T < 5 ng/dL plus 3 or more symptoms of hypogonadism
  • In a health screening project among 819 men in Taiwan, the prevalence of hypogonadism (total serum T < 300 ng/dL) ranged from 16.5% for men in their 40s, 23.0% for men in their 50s, 28.9% for men in their 60s, and 37.2% for men older than 70 years of age
  • The prevalence of hypogonadism among men in Taiwan is higher than the prevalence reported in the Massachusetts Male Aging Study
  • CAG repeat sequence, within the androgen receptor (AR). Rajender et al[12] reviewed over 30 studies on the AR trinucleotide repeat and infertility
  • suggestion that CAG repeat length may determine androgen responsiveness, this issue is not clearly settled
  • reported prevalence of low T in older men range from 5.6% to 50%
  • Those in the hypogonadal group (n = 4269) had direct health care costs, that exceeded the eugonadal group (n = 4269) by an average of $7100 over the course of the observation window
  • higher economic burden and presence of co-morbidities for hypogonadism
  • minor to moderate improvements in lean mass and muscle strength
  • increased bone mineral density
  • modest enhancement in sexual function
  • reduced adiposity
  • lessening of depressive symptoms
  • Meta-analyses of clinical TRT trials as of 2010 have identified three major adverse events resulting from TRT: (1) polycythemia; (2) an increase in prostate-related events; and (3) and a slight reduction in serum high-density lipoprotein (HDL) cholesterol
  • polycythemia (> 3.5-fold increase in risk
  • TRT produced a 40% prostate enlargement in older hypogonadal male Veterans over 12 mo
  • no published analysis has reported measurable increases in prostate cancer risk or Gleason score in men undergoing TRT, or in hypogonadal men with a history of prostate cancer undergoing TRT
  • the prostate which highly expresses the type II 5α-reductase enzyme. Inhibition of this enzyme via finasteride (a type II 5α-reductase inhibitor) or dutasteride (a dual type I and II 5α-reductase inhibitor) reduces circulating DHT 50%-75% and > 90%, respectively[47], and reduces prostate mass[48] and prostate cancer risk
  • Normally estradiol partially regulates testosterone levels, at the hypothalamus, blunting LH and FSH release from the pituitary. As a selective estrogen receptor modulator, CC interrupts this pathway, and consequently there is a greater stimulation for the production of testosterone in Leydig cells
    • Nathan Goodyear
      Nathan Goodyear on 28 Apr 15
       
      this would only apply if E1 and/or E2 levels were elevated, which the authors make no mention of.
  • Nathan Goodyear on 28 Apr 15
     
    to be read
Nathan Goodyear

Elderly men over 65 years of age with late-onset hypogonadism benefit as much from test... - 0 views

www.ncbi.nlm.nih.gov/...PMC4392031

low T low Testosterone Testosterone men male hormone hormones late onset hypogonadism hypogonadism

shared by Nathan Goodyear on 21 May 15 - No Cached
  • The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
  • obesity, but also impaired general health, are the more common causes of low testosterone in aging men
  • Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
  • ...30 more annotations...
  • advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
  • Diabetes mellitus was correlated with hypogonadism in most studies
  • coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
  • LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
    • Nathan Goodyear
      Nathan Goodyear on 27 May 15
       
      the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.  
  • Mean weight decreased
  • Waist circumference decreased
  • Total cholesterol decreased
  • Low-density lipoprotein decreased
  • Triglycerides decreased
  • High-density lipoprotein (HDL) increased
  • ratio of total cholesterol to HDL improved
  • Prostate volume increased
  • PSA increased
  • The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
  • weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
  • Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
  • observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
  • the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
  • The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
  • it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
  • Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
  • Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
  • These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
  • The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
  • Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
  • This apparent paradox is explained by the "saturation model,"
  • Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
  • In the present observational study, no cases of major adverse cardiovascular events occurred.
  • the benefits of testosterone therapy are fully achieved only by long-term treatment
  • To achieve maximal benefits, good patient adherence is a prerequisite
  • Nathan Goodyear on 21 May 15
     
    Study finds new difference in Testosterone benefits and/or side effects between men < 65 with low T and men > 65 with low T.
Nathan Goodyear

Correlation analysis between bovine populations, o... [Neuroepidemiology. 1993] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...8327019

cow's milk MS

shared by Nathan Goodyear on 17 May 11 - No Cached
  • Here again we find significant correlations between (i) cow milk production per inhabitant, (ii) national bovine density per inhabitant, and (iii) local bovine geographic density, and MS prevalence. However, these correlations are relatively weaker than that found with fresh liquid milk consumption in our previous study
  • Nathan Goodyear on 17 May 11
     
    Cow's milk as cofactor in MS
Nathan Goodyear

ScienceDirect - Clinical Biochemistry : Correlation between total homocysteine, low-den... - 0 views

www.sciencedirect.com/...S0009912001001874

homocysteine heart attack myocardial infarction

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • usefulness of LDL-C, HDL-C and serum total homocysteine as prognostic markers in myocardial infarction patients
  • Nathan Goodyear on 03 Aug 11
     
    homocysteine shown to be a good prognostic marker for patients with prior heart attacks
Nathan Goodyear

Effects of dietary calcium compared with calcium supplements on estrogen metabolism and... - 0 views

www.ajcn.org/...1428.abstract

calcium dietary supplement supplementation bone density mineral

shared by Nathan Goodyear on 15 Aug 11 - No Cached
  • Nathan Goodyear on 15 Aug 11
     
    dietary calcium proves to be better source than Calcium supplement
Nathan Goodyear

The association between serum dehydroepiandrosterone sulfate (DHEA-... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25692973

DHEA DHEA-S DHEAS BMD osteoporosis men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Only abstract available here, but lower DHEA-S (still in reference normal range) associated with lower bone mineral density and increased osteoporosis risk.
Nathan Goodyear

Lower low density lipid cholesterol levels are associated with Parkinson's disease - 0 views

www.ncbi.nlm.nih.gov/...PMC1906875

LDL cholesterol Parkinson's Parkinson's disease statins Parkinsons disease brain health low density cholesterol

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • Nathan Goodyear on 19 Mar 15
     
    Lower LDL levels associated with increased risk of Parkinson's disease.  LDL levels < 113 were associated with a 3.5 fold increase in Parkinson's disease compared to LDL of 138.
wheelchairindia9

Cervical Pillow Regular - 0 views

www.wheelchairindia.com/...Cervical-Pillow-Regular

Cervical Pillow Regular tynor cervical pillow vissco cervical pillow cervical pillow memory foam tynor cervical pillow regular srm cervical pillow cervical neck support pillow

shared by wheelchairindia9 on 24 Feb 16 - No Cached
  • wheelchairindia9 on 24 Feb 16
     
    Cervical pillow is designed to keep the neck in the slightly hyperextension position at night to counter the stress and strain of the day where we tend to keep the neck in the opposite "flexion" position. It cures the cervical problems while you sleep. Cervical Pillow Regular Specifications Optimal foam density Scientific design Resilient PU foam Cervical Pillow Regular Features: Provides muscle relaxation Proper support to neck Plush covering Provides soft feel Good aesthetics. Durablity
wheelchairindia9

Tynor Cervical Pillow Regular - 0 views

www.wheelchairindia.com/...Tynor-Cervical-Pillow-Regular

Tynor Cervical Pillow Regular Cervical Pillow Regular For sale Cervical Pillow Regular Online Buy Cervical Pillow Regular Cervical Pillow Regular Price Cervical Pillow Regular Tynor Cervical Pillow Regular India

shared by wheelchairindia9 on 07 Apr 16 - No Cached
  • wheelchairindia9 on 07 Apr 16
     
    Tynor Cervical Pillow Regular Cervical pillow is designed to keep the neck in the slightly hyperextension position at night to counter the stress and strain of the day where we tend to keep the neck in the opposite "flexion" position. It cures the cervical problems while you sleep. Optimal foam density. Scientific design. Plush covering. Resilient PU foam. Tynor Cervical Pillow Regular Features Soft and cushiony, more comfort, good resilience, effective support to the neck and longer functional life. Maintains the neck in slight hyperextension, provides muscle relaxation and proper support to neck. Provides soft feel, good aesthetics and durability. Tynor Cervical Pillow Regular Measurements Measure distance between edge of sternum and lower jaw with neck in extension position.
Nathan Goodyear

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Deg... - 0 views

www.ncbi.nlm.nih.gov/...PMC3501844

exercise diabetes epigenetics muscle mitochondria VO2max

shared by Nathan Goodyear on 03 Oct 17 - No Cached
  • epigenetic modifications of single genes have been shown to affect the pathogenesis of T2D
  • An FH of T2D is an independent predictor of future risk for the disease
  • exercise for 6 months is associated with epigenetic changes, e.g., decreased DNA methylation of RUNX1 and MEF2A, two key transcription factors involved in exercise training (42–44), of THADA, previously associated with T2D (1), and of NDUFC2, which is part of the respiratory chain (45) was observed after exercise
  • ...4 more annotations...
  • exercise changed both DNA methylation and expression of a number of genes, including ADIPOR1, ADIPOR2, and BDKRB2, encoding receptors for adiponectin and bradykinin, respectively, which both regulate metabolism in muscle
  • we cannot draw a conclusion as to whether differential expression is a consequence rather than a cause of changes in methylation
  • ageing is associated with increased DNA methylation and decreased expression of genes involved in oxidative phosphorylation in human muscle
  • exercise can induce genome-wide epigenetic changes in human muscle and that the response may differ in people with different genetic predispositions to metabolic disease
  • Nathan Goodyear on 03 Oct 17
     
    Six months of exercise induce epigenetic changes through decrease in methylation.  This study was designed to look at those with a family risk of DM.  They found a difference in the methylation status of muscle between those with a family h/o diabetes and those without.  This would have implications in therapeutic difference prior to diagnosis.  Even a increased VO2max and skeletal muscle mitochondrial density was found to be the result of decreased methylation of the NDUFC2 gene after exercise.
Nathan Goodyear

Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the ... - 0 views

www.nejm.org/...NEJMoa021993

CRP c-reactive protein LDL cholesterol cardiovascular disease cardiovascular events

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    CRP is more predictive than LDL in predicting cardiovascular events.
Nathan Goodyear

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and R... - 0 views

www.ncbi.nlm.nih.gov/...27701660

statins diabetes LDL

shared by Nathan Goodyear on 27 Oct 16 - No Cached
  • Nathan Goodyear on 27 Oct 16
     
    statins associated with increase risk of type II diabetes for some with genetic variants.
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