Skip to main content

Home/ Dr. Goodyear/ Group items tagged coronary

Rss Feed Group items tagged

Nathan Goodyear

Statins use and coronary artery plaque composition: Results from the International Mult... - 0 views

  • Statin use is associated with an increased prevalence and extent of coronary plaques possessing calcium
  • As compared with individuals not taking statins, those taking statins possessed a significantly higher prevalence of obstructive CAD, as well as higher numbers of vessels with obstructive CAD
  • non-calcified plaques (NCP)
  • ...11 more annotations...
  • non-calcified (NCP), mixed (MP), or calcified (CP) plaque
  • statin use was each associated with a significantly higher prevalence of NCP, MP and CP
  • statin use was associated with increased presence of MP [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.27–1.68, p < 0.001] and CP (OR 1.54, 95% CI 1.36–1.74, p < 0.001], but not NCP
  • statin use was associated with increasing numbers of coronary segments possessing MP and CP but not associated with increasing numbers of coronary segments possessing NCP
  • North America, Europe and Asia
  • A total of 6673 individuals (2413 on statin therapy and 4260 not on statin therapy) comprised the study population
  • we identified a strong association of statin use to coronary artery plaque features
  • statin use was associated with a differentially increased prevalence and extent of MP and CP
  • one potential unifying hypothesis is that rather than regression of coronary plaque, statins may contribute to the conversion of coronary plaque constituents, perhaps by conversion of NCP to plaque possessing calcium
  • Coronary computed tomographic angiography (CCTA)
  • Statin use was associated with a higher frequency of severe coronary artery stenoses as well as numbers of coronary vessels with obstructive CAD
  •  
    Study finds statin therapy associated with increased coronary plaque with calcium.
Nathan Goodyear

What does my patient's coronary artery calcium score mean? Combining information from t... - 0 views

  •  
    good review of the coronary calcium score and associated risk estimates.
Nathan Goodyear

CORONARY ARTERY CALCIUM SCORE VERSUS A MULTIPLE BIOMARKER APPROACH FOR CORONARY HEART D... - 0 views

  •  
    Coronary artery calcium is positively associated with CAD risk.  It compares to multiple biomarker assessment, BNP, and homocysteine assessment.
Nathan Goodyear

Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term... - 0 views

  •  
    Study finds that 57% of study participants saw a 14% reduction in coronary calcium score with combined EDTA plus tetracycline.  The reduction may seem modest, and it is, but the delivery method of the EDTA is going to limit the effects.  EDTA should be given IV.
Nathan Goodyear

Dietary patterns and the risk of major adverse cardiovascular events in a global study ... - 0 views

  •  
    Mediterranean diet reduces major cardiovascular event incidence in those individuals with coronary artery disease.
Nathan Goodyear

The omega-3 index as a risk factor for coronary heart disease - 0 views

  •  
    Omega-3 fatty acids can be used to predict risk for coronary heart disease death, especially sudden cardiac death.
Nathan Goodyear

Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Art... - 0 views

  •  
    SNP in 4q25 associated with increased Atrial fibrillation post coronary artery bypass.
Nathan Goodyear

Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels - NEJM - 0 views

  •  
    lowering homocysteine reduced the rate of coronary restenosis.  A combination of folic acid, Vitamin B12, and Vitamin B6 were used to lower homocysteine.
Nathan Goodyear

Sex steroids and cardiovascular disease Yeap BB - Asian J Androl - 0 views

  • Levels of SHBG are higher in older men, therefore levels of free T decline more steeply than total T as men's age increases.
  • calculations based on mass action equations may not reflect precisely free T measured using a reference method
  • free T declines more steeply with age than total T in both cross-sectional [35] and longitudinal studies, [36] as does free E2 in comparison to total E2
  • ...22 more annotations...
  • T may slow development of or progression of atherosclerosis by modulating effects on insulin resistance, inflammation, endothelial function, preclinical atherosclerosis or the vasculature.
  • these cross-sectional and longitudinal studies support a relationship between low circulating T with CIMT and higher E2 with its progression
  • lower levels of T are biomarkers for aortic vascular disease
  • circulating free T was negatively associated with the presence of AAA
  • luteinizing hormone (LH) was positively associated.
  • low levels of total or bioavailable T were associated with aortic atherosclerosis manifested as calcified deposits detected by radiography
  • Men with total or free T in the lowest quartile had increased adjusted ORs for PAD defined as ABI <0.90, as did men with free E2 in the highest quartile of values
  • The apparent association of SHBG with intermittent claudication reflects the correlation of total T with SHBG, while the contribution of E2 to risk of PAD remains unclear
  • men with total T in the lowest quartile of values (<11.7 nmol l−1 ) experienced an increased incidence of stroke or transient ischemic attack
  • lower total T with increased incidence of CVD events
  • cohort studies in mostly older men have supported the association of lower androgen levels with higher mortality
  • lower total or free T levels were associated with mortality in older men, but with discordant results for cause-specific mortality and for associations of E2
  • several large studies identifying lower endogenous levels of total or free T as independent predictors of all-cause or CVD-related deaths in middle-aged and older men
  • T exhibits anti-inflammatory effects, enhances flow-mediated brachial artery reactivity, and reduces arterial stiffness
  • Short-term T therapy had a beneficial effect on exercise-induced myocardial ischemia in middle-aged men with coronary artery disease or chronic stable angina, [95],[96],[97] and reduced angina frequency in older men with diabetes and coronary artery disease
  • T therapy resulted in an increase in treadmill test duration and time to ST segment depression
  • there are interventional studies supporting a protective effect of exogenous T against myocardial ischemia in men with coronary artery disease
  • employ conservative doses
    • Nathan Goodyear
       
      This dosing is 100 fold higher then peak production of a  young man at 20-22.
  • Observational studies indicate that lower levels of endogenous T in older men are associated with the presence of carotid atherosclerosis, aortic and peripheral vascular disease, and incidence of CVD events and mortality
  • Interventional studies have shown beneficial effects of exogenous T on vascular function and on exercise-induced myocardial ischemia in men with coronary artery disease
    • Nathan Goodyear
       
      the therapies employed in these studies were massively overdosed.
  •  
    Nice review of all the sex hormones and their relationship to CVD in men.  
Nathan Goodyear

A reverse J-shaped association of leisure time physical activity with prognosis in pati... - 0 views

  •  
    Increased risk of cardiovascular events and all-cause mortality is highest in the least active population in those with coronary heart disease.  However, those with the highest, strenuous physical activity were also at increased risk--though less than the inactive group.
Nathan Goodyear

Coronary Artery Calcium Scores: Current Thinking and Clinical Applications - 0 views

  •  
    coronary artery calcium scores
Nathan Goodyear

Interpretation of the Coronary Artery Calcium Score in Combination with Conventional Ca... - 0 views

  •  
    A more recent article on the interpretation of the coronary calcium score.  Score alone must be taken in context with the individual.
Nathan Goodyear

The association between androgen levels and premature coronary artery disease in men. -... - 0 views

  •  
    low free Testosterone is found to be associated with a 3.3 fold increased risk of premature coronary artery disease.  The free Testosterone here is 17.3 pg/ml, but could be as high as 25 pg/ml.  
indian-health

Top 12 Cardiologists in Bangalore Leaders in the Treatment of Coronary Artery Disease - 0 views

  •  
    Best cardiac surgery hospitals Bangalore recently received the coveted three-star rating from the Society of Thoracic Surgeons (STS) for its patient care and outcomes in isolated coronary artery bypass grafting (CABG) procedures.
Nathan Goodyear

Low serum testosterone and increased mortality in men with coronary heart disease -- Ma... - 0 views

  •  
    low serum testosterone associated with increased mortality in men with coronary disease. This study used "bio-available" testosterone and total testosterone.
Nathan Goodyear

Running: the risk of coronary events † - 0 views

  •  
    This study shows that "healthy marathon" runners may not be as healthy as once thought.  Basically, current strategies to assess coronary artery calcification is inadequate.  Point: damage is being done that is not being detected.
Nathan Goodyear

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge H... - 0 views

  •  
    vitamin E, in doses up to 800 IU daily, found to be safe and effective in reducing risk of non-fatal MI in individuals with symptomatic coronary atherosclerosis.
Nathan Goodyear

Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart diseas... - 0 views

  •  
    low DHEA and DHEA-S associated with increased risk of Coronary Heart Disease in elderly men.
Nathan Goodyear

Low serum testosterone level was associated with extensive coronary artery calcificatio... - 0 views

  •  
    In men > 65, low Testosterone is associated with CAD.
Nathan Goodyear

Hostility and physiological responses to laborator... [J Psychosom Res. 2010] - PubMed ... - 0 views

  •  
    saliva cortisol testing used to evaluate stress in coronary syndrome patients
1 - 20 of 119 Next › Last »
Showing 20 items per page