Group items tagged

Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.

metformin shown to result in increased homocysteine through depletion of folate. Metformin is also known to deplete vitamin B12 and CoQ10.  

It appears that Levodopa administration in those with Parkinson's disease will deplete methylation (SAMe), and thus increase homocysteine, which is a neurotoxin.  Additionally, depletion of methylation is associated with depression, commonly seen in Parkinson's disease

Good list of drug-induced nutrient depletions

The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.

Critically ill patients found to be depleted in glutathione, vitamin C, Zinc, and too a lesser extent: vitamin E.  The obvious treatment would be to replace those identified deficiencies

Elevated ammonia depletes glutamate and BCCA in muscle and plasma.  A decrease in BCCA is through an up regulation of glutamine in an attempt to eliminate ammonia.

Patients with CAP found to be depleted of vitamin C...a metabolic scurvy if you will.

Depletion of glutathione is means of triggering cytotoxicity in leukemia cells. Detoxification crisis is at the heart of the means to destroy cancer cells.

Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  

in this study, children with autism found to have detoxification impairment.  Particularily here, methylation disruption and glutathione depletion.

good read on glutathione in MS.  Glutathione is depleted in MS.  

new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!

animal model finds that glutathione depletion increases hyperactivity of bronchioles.  Early exposure to glutathione ethyl ester, a precursor to glutathione, blunted the airway hyperactivity.

ketogenic diet found to not deplete muscle glycogen in endurance athletes.  The metabolism of the endurance athletes can do this via the high fat oxidation--estimates of 80%.

statin therapy shown to decrease genetic expression of the ubiquitin proteasome pathway.   Not only do statins damage mitochondria through CoQ10 depletion, but this study shows a new component of the damage statins do: they actually change the human genetic expression.  This should startle you.

SAMe, at doses of 1200 mg, shown to decrease mortality rate and prolong transplantation in those with cirrhosis.  Very likely, these individuals, if tested, had low SAMe and methyl donors as well as depleted glutathione. This is a set up for low phosphotidyl choline/ethanolamine levels resulting in fat accumulation.

glutathione depletion plays early, active role in the development of Parkinson's disease

glutathione depletion could be used as an early marker in Parkinson's Disease

Vitamin B12 deficiency will decrease methionine synthase activity, which will result in elevated homocysteine and the risk of DVT increases as a result.  In this article, the cause of the vitamin B12 depletion was metformin.  Diabetics and those with insulin resistance are already at an increased risk of blood clots.