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indiacardiacsurg

New Heart Transplant Program Launched by Dr. Naresh Trehan India - 0 views

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    Under the best cardiac surgeon in Gurgaon's leadership, the heart transplant program will provide low-cost hospitals for heart transplant surgery in India with individualized treatment for patients with advanced heart failure in India. Dr. Naresh Trehan India will see patients alongside cardiologists, as well as nurse practitioners, social workers, and other specialists to provide comprehensive care and support patients with end-stage heart disease. For Appointment- +91-9370586696 Email id: nareshtrehan@indiacardiacsurgerysite.com
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

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    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

ESC | Congresses | HEART FAILURE 2013 | Scientific Programme - 0 views

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    CoQ10 in those with prior MIs, found to have reduced hospital readmission, less heart failure, and lower cardiovascular death.  Enough said.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
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  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
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    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

Thyroid hormone and heart failure. [Curr Heart Fail Rep. 2006] - PubMed - NCBI - 0 views

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    Hypothyroidism is found to be associated with low T3, reduced heart contractility, and poor prognosis in heart failure
Nathan Goodyear

Testosterone Supplementation in Heart Failure - 0 views

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    Review of 4 studies found that Testosterone therapy improved exercise capacity in those patients with heart failure.
Nathan Goodyear

Low vitamin C levels may raise heart failure patients' risk / American Heart Association - 0 views

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    patients with heart failure and low vitamin C levels have higher inflammation as measured by hs-CRP and elevated risk of worse outcomes
indian-health

Cardiac Surgery India Provides Expertise in All Aspects of Cardiac Care - 0 views

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    Cardiac surgery India is one of the highest in the world, all thanks to heart failure surgeons in India who excel in conducting heart surgery.
Nathan Goodyear

Heart failure improvement from a supplement containing copper | European Heart Journal - 0 views

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    heart failure improved with copper supplementation.
Nathan Goodyear

Cross-sectional relationship of a Mediterranean type diet to diastolic heart function i... - 0 views

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    Cardiac systolic/diastolic function improved with Mediterranean diet in individuals with chronic heart failure.
Nathan Goodyear

Effect of the Mediterranean diet on heart failure biomarkers: a randomized sample from ... - 0 views

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    Mediterranean diet reduces heart failure risk as determined by modified biomarkers: decreased ox LDL, natriuretic peptide...
Nathan Goodyear

Will testosterone replacement therapy become a new treatment of chronic heart failure? ... - 0 views

  • TRT could improve significantly the exercise capacity of patients, compared with placebo
  • it could be seen that the effect of TRT on SBP and DBP was controversial
  • in men with congestive heart failure, testosterone reduced the Q-Td, whereas placebo had no effects
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  • The MVC and PTmax were significantly improved in TRT patients but remained unchanged in the placebo group
  • handgrip strength improved significantly with testosterone treatment
  • According to EF assessed by echocardiography, no differences were observed between the patients who were prescribed testosterone and those who received placebo
  • There were no differences between the groups in circulating levels of NT pro-BNP, and inflammatory markers were unchanged, except for a decrease in TNF-α from baseline in the placebo group
  • Testosterone supplementation therapy appeared to be safe, and the subjects who accepted testosterone treatment did not appear any obvious adverse reactions.
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    Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.
Nathan Goodyear

Arch Intern Med -- Abstract: Subclinical Hypothyroidism and the Risk of Heart Failure, ... - 0 views

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    subclinical hypothyroidism associated with increased risk of heart failure
Nathan Goodyear

Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure: The C... - 0 views

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    increased risk of heart failure found in patients with TSH > 10.
Nathan Goodyear

Testosterone supplementation in Heart Failure: A meta-analysis - 0 views

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    study shows that testosterone therapy provides benefits in heart failure patients.
Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

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    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
Nathan Goodyear

Safety and hemodynamic effects of intravenous trii... [Am J Cardiol. 1998] - PubMed result - 0 views

  • Acute intravenous administration of triiodothyronine is well tolerated in patients with advanced heart failure
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    T3 beneficial in those with acute heart failure
Nathan Goodyear

Thyroid hormone abnormalities in heart failure: po... [Thyroid. 1996] - PubMed result - 0 views

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    T3 improves cardiac output in those with heart failure
Nathan Goodyear

Uric acid in chronic heart failure: a marker of chronic inflammation - 0 views

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    uric acid is inflammatory marker associated with chronic heart failure
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

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    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
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