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Nathan Goodyear

Folates and Cardiovascular Disease -- Verhaar et al. 22 (1): 6 -- Arteriosclerosis, Thr... - 0 views

atvb.ahajournals.org/...6

cardiovascular folates disease folate folic acid

shared by Nathan Goodyear on 29 Apr 11 - No Cached
  • benefits of folates independent of homocysteine lowering have also been reported. Potential mechanisms include antioxidant actions, effects on cofactor availability, or direct interactions with the enzyme endothelial NO synthase
  • beneficial effects of folates on cardiovascular risk
  • Nathan Goodyear on 29 Apr 11
     
    Folate improves cardiovascular disease risk
Nathan Goodyear

Folate | Linus Pauling Institute | Oregon State University - 0 views

lpi.oregonstate.edu/...folate

Folate folic acid MTHFR micronutrients

shared by Nathan Goodyear on 23 Aug 15 - No Cached
  • Nathan Goodyear on 23 Aug 15
     
    Nice review on the difference b/t Folate and Folic acid.  Also, brief but worthy of a read, review of the MTHFR polymorphism 677.
Nathan Goodyear

Nutrition and Depression: The Role of Folate : The Basis for Folate Deficiency in Depre... - 0 views

www.medscape.com/...431514_5

folate folic acid B12 depression

shared by Nathan Goodyear on 08 Dec 10 - No Cached
  • Nathan Goodyear on 08 Dec 10
     
    24% of patients with depression had low folate levels; 13% had low B12
Nathan Goodyear

Folate: effects on carcinogenesis and the potentia... [Oncology (Williston Park). 1996]... - 0 views

www.ncbi.nlm.nih.gov/...8953590

folate folic acid cancer risk

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • Diminished folate status appears to promote carcinogenesis.
  • Nathan Goodyear on 15 Feb 11
     
    folate deficiency linked to increase cancer risk
Nathan Goodyear

Folate: Effects on Carcinogenesis and the Potential For Cancer Chemoprevention - Psychi... - 0 views

www.psychiatrictimes.com/...82893

Folate folic acid cancer

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • Nathan Goodyear on 24 Nov 10
     
    Folate deficiency increases risk of Cancer
Nathan Goodyear

Effects of metformin with or without supplemen... [Diabetes Care. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19933994

metformin PCOS diabetes DM homocysteine Folic acid folate vitamin B12 CoQ10 drug-induced nutrient depletion

shared by Nathan Goodyear on 06 Feb 12 - No Cached
  • Nathan Goodyear on 06 Feb 12
     
    metformin shown to result in increased homocysteine through depletion of folate. Metformin is also known to deplete vitamin B12 and CoQ10.  
Nathan Goodyear

SpringerLink - Environmental Health and Preventive Medicine, Volume 7, Number 4 - 0 views

www.springerlink.com/...35l447247110p261

green tea folate health

shared by Nathan Goodyear on 25 Nov 11 - No Cached
  • Nathan Goodyear on 25 Nov 11
     
    green tea is a good source of folate in japanese diets
Nathan Goodyear

Targeting Synaptic Dysfunction in Alzheimer's Disease by Administering a Specific Nutri... - 0 views

iospress.metapress.com/...gg33167h46757165

alzheimer's disease Alzheimer's disease DHA EPA Folate B12 B6 vitamin E C vitamins brain

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Combination of DHA, EPA, choline, phospholipids, Folate, B12, B6, vitamin C and E, and selenium improves memory and cognitive function in those with mild Alzheimer's disease.
Nathan Goodyear

ScienceDirect - The Lancet : Enhancement of recovery from psychiatric illness by methyl... - 0 views

www.sciencedirect.com/science

folate folic acid depression

shared by Nathan Goodyear on 08 Dec 10 - No Cached
  • Nathan Goodyear on 08 Dec 10
     
    1/3 of patients with depression improved with folate replacement
Nathan Goodyear

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in c... - 0 views

www.ajcn.org/...425.short

vitamin B12 Folate Folinic Acid autism spectrum disorders

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • Nathan Goodyear on 28 Jun 11
     
    Active Vitamin B12 and Folate treatment benefits some children with autism spectrum disorders
Nathan Goodyear

PayPerView: A Randomized Study of Low-Dose Subcutaneous lnterleukin-2 Plus Melatonin ve... - 0 views

www.karger.com/...227465

IL-2 cancer melatonin colon cancer colorectal cancer

shared by Nathan Goodyear on 09 Nov 18 - No Cached
  • Nathan Goodyear on 09 Nov 18
     
    Percent survival at 1 year was significantly increased in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05) in study which suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates
Nathan Goodyear

Homocysteine, folate, methylation, and monoamine metabolism in depression -- Bottiglier... - 0 views

jnnp.bmj.com/228

homocysteine depression methylation Folate 5-MTHF Folic Acid psychiatry neurology

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    elevated homocysteine associated with a 2 x higher incidence of depression versus those with low homocysteine.  Methylation plays a role in depression.
Nathan Goodyear

Homocysteine and folate as risk factors for dementia and Alzheimer disease - 0 views

www.ajcn.org/...636.full

dementia alzheimer disease homocysteine folic acid folate

shared by Nathan Goodyear on 23 Jul 12 - No Cached
  • Nathan Goodyear on 23 Jul 12
     
    elevated homocysteine and low folic acid levels associated with increased risk of Alzheimer's disease and dementia.
Nathan Goodyear

Serum Folate, Homocysteine, Brain Atrophy, and Auto-CM System: The Treviso Dementia (TR... - 0 views

iospress.metapress.com/...d265g716533w7m71

Folate folic acid brain homocysteine dementia alzheimer disease

shared by Nathan Goodyear on 04 Dec 13 - No Cached
  • Nathan Goodyear on 04 Dec 13
     
    Folic acid inversely associated with brain atrophy.  Also, homocysteine is associated directly with brain atrophy in the cortical, subcortical, and hippocampus regions.
Nathan Goodyear

http://jpmph.org/upload/pdf/jpmph-45-387.pdf - 0 views

jpmph.org/...jpmph-45-387.pdf

Pb lead homocysteine

shared by Nathan Goodyear on 18 Sep 14 - No Cached
  • Nathan Goodyear on 18 Sep 14
     
    Blood lead levels correlate with homocysteine levels.  Methylation (B12, Folate, B6) plays a role regulating homocysteine levels as well. 
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

mitochondria oxidative stress heart failure heart

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
      Nathan Goodyear on 19 Mar 13
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
  • Nathan Goodyear on 19 Mar 13
     
    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

Homocysteine and MTHFR Mutations - 0 views

circ.ahajournals.org/...e289.full

homocysteine MTHFR CVD cardiovascular death CAD c677T A1298c

shared by Nathan Goodyear on 02 Feb 15 - No Cached
  • The most common MTHFR mutation is called the MTHFR C677T mutation
  • Another common mutation is called MTHFR A1298C
  • Having only one mutation, ie, being heterozygous, is, from a medical perspective, irrelevant. Even when 2 MTHFR mutations are present (eg, 2 C677T mutations, or one C677T mutation and one A1298C mutation)
  • ...4 more annotations...
  • Although these mutations do impair the regulation of homocysteine, adequate folate levels essentially “cancel out” this defect.
  • Regardless of whether you have an MTHFR mutation in both genes or not, the treatment for elevated homocysteine is the same—dietary intervention and supplementation with folic acid and vitamins B6 and B12
  • Overall, evidence from these studies indicates that, so long as the homocysteine level is normal, MTHFR mutations do not significantly increase the risk of heart attack or stroke
  • Studies investigating the association of MTHFR mutations and venous blood clots have been inconsistent, with some studies showing a slight association, but most studies have not shown any association
  • Nathan Goodyear on 02 Feb 15
     
    Good review of MTHFR and homocysteine.
Nathan Goodyear

Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels - NEJM - 0 views

www.nejm.org/...NEJMoa011364

homocysteine vitamin B12 B6 folic acid folate coronary angioplasty

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    lowering homocysteine reduced the rate of coronary restenosis.  A combination of folic acid, Vitamin B12, and Vitamin B6 were used to lower homocysteine.
Nathan Goodyear

Effect of folic acid supplementation on the ... [Atherosclerosis. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22209480

IMT folic acid folate carotid intima-medial thickness atherosclerosis CAD

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    A common tool to monitor the progression of atherosclerosis is carotid intima-medial thickness.  This meta-analysis showed that folic acid reduces carotid intimal medial thickness.
Nathan Goodyear

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease - NEJM - 0 views

www.nejm.org/...NEJMoa060900

HOPE-2 trial vitamin B12 Vitamins B6 folic acid folate homocysteine CVD cardiovascular disease events stroke MI

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, B6, and folic acid shown to lower homocysteine levels and decreased the incidence of stroke.  However, overall mortality and CVD deaths were not.
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