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wheelchairindia9

Wrist and Forearm Splints Causes and Recovery Period | Health | Article Point - 0 views

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    Wrist and forearm splints may be suggested for people with weak wrists or for those that have been previously injured, for tendonitis wrist support and even as a preventative for those who awaken in the morning with pain or numbness after sleeping on their hands at night. The best orthopedic wrist braces for carpal tunnel syndrome, occupational stabilization and relief from the pain of wrist strains and sprains. This Right hand wrist and forearm splint from tynor is meant to be used among patients suffering from any injury or sprain in these regions. The splint is meant to provide controlled compression in various orthopaedic conditions. The splint immobilizes the area that helps in a speedier recovery. It has anatomical thumb opening that allows free movement of the thumb. It provides a lot of comfort and is easily breathable. Forearm splint is the term used to describe the forearm pain similarly the pain of lower leg over the shin is known as shin splints. Forearm splint describes the painful disease of elbow or wrist joint. Continuous pain in forearm is often caused by tendonitis, joint injury or hairline fracture of forearm bones (proximal radius or ulna near elbow joint). Overstretching of the elbow joint often causes forearm injury. Symptoms consist of a dull pain in the forearm. Pain is minor initially but increases as activity continues. Often pin-pointed to the dorsal or back of the hand side of the forearm, mid-way between the wrist and elbow. The patient may experience weakness in the wrist extensor muscles and tenderness deep in the forearm. Pain may be reproduced by attempting to bend the wrist backwards against resistance. They provided wrist splints are used in different medical institutions and hospitals for management of hand fractures. Our offered wrist splints are manufactured by skilled professionals using optimum quality basic material and advanced technology as per the set norms of market. As well, these wrist splints can be availed in v
Nathan Goodyear

Hypercalcemia of malignancy and new treatment options - 0 views

  • Hypercalcemia of malignancy occurs as the result of direct bone metastasis and via humoral mechanisms such as parathyroid hormone-related protein (PTHrP) or 1,25-dihydroxyvitamin D mediated pathways
  • ectopic secretion of parathyroid hormone (PTH) has been implicated
  • Hypercalcemia due to osteolytic bone lesions is common in multiple myeloma, leukemia, and breast cancer
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  • Humoral hypercalcemia is predominant in squamous cell, renal cell and ovarian cancers, and lymphomas are associated with 1,25-dihydroxyvitamin D mediated hypercalcemia
  • 20% of cases of hypercalcemia of malignancy and is frequently encountered in multiple myeloma, metastatic breast cancer, and to a lesser extent in leukemia and lymphoma
  • Physiologic bone turnover requires the complementary activity of osteoblasts – mesenchymal stem cell-derived bone-forming cells – and bone-resorbing cells of monocyte and macrophage lineage known as osteoclasts
  • In local osteolytic hypercalcemia, the RANKL/RANK interaction results in excessive osteoclast activation leading to enhanced bone resorption and thus hypercalcemia
  • In addition, osteoclast activation is also mediated by malignancy secreted cytokines, including interleukin-1, initially termed “osteoclast stimulating factor”
  • Macrophage inflammation protein 1-alpha (MIP 1-alpha)
  • hypercalcemia is through extra-renal 1,25-dihydroxyvitamin D (calcitriol) production
  • 1% of cases
  • increased production of 1,25-dihydroxyvitamin D occurs nearly exclusively in Hodgkin and non-Hodgkin lymphoma with case reports of the same in ovarian dysgerminoma
  • 1-α-hydroxylase in the kidney, a process regulated by PTH
  • in 1,25-dihydroxyvitamin D induced hypercalcemia, malignant cells likely recruit and induce adjacent macrophages to express 1-α-hydroxylase, converting endogenous calcidiol into calcitriol.31 Calcitriol then binds to receptors in the intestine leading to heightened enteric calcium reabsorption with resultant hypercalcemia
  • this mechanism of disease is best conceptualized as an absorptive form of hypercalcemia
  • Ectopic production of PTH by malignant cells has been described in a handful of cases involving cancer of the ovary and lung, as well as neuroendocrine tumors and sarcoma
  • primary hyperparathyroidism and malignancy comprising nearly 90% of cases of hypercalcemia
  • an initial panel consisting of PTH, PTHrP, phosphorus, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D should be obtained
  • Lymphoma, a hypercalcemia due to 1,25-dihydroxyvitamin D mediated pathways, is implied by elevations in 1,25-dihydroxyvitamin D without concomitant elevations in 25-hydroxyvitamin D. In such cases, PTH is low and PTHrP undetectable
  • Treatment of hypercalcemia of malignancy is aimed at lowering the serum calcium concentration by targeting the underlying disease, specifically by inhibiting bone resorption, increasing urinary calcium excretion, and to a lesser extent by decreasing intestinal calcium absorption
  • mildly symptomatic disease
  • marked symptoms
  • hydration with isotonic fluid (if admitted), avoidance of thiazide diuretics, and a low-calcium diet
  • denosumab
  • Denosumab is an RANKL antibody that inhibits osteoclast maturation, activation, and function
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    hypercalcemia in cancer and treatments.
Nathan Goodyear

Doxycycline Decreases Tumor Burden in a Bone Metastasis Model of Human Breast Cancer | ... - 0 views

  • it appears more likely that the effectiveness relies on the properties of doxycycline as an inhibitor of tumor cell proliferation and less on its effect as a MMP inhibitor
  • Our results suggest that doxycycline may be useful not only for the treatment of osteolytic but also for the treatment of osteoblastic bone metastasis
  • A prominent feature of bone metastasis of breast cancer is the uncoupling of bone remodeling
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  • doxycycline can improve this to some extent by increasing bone formation
  • the current study clearly demonstrates the benefit of doxycycline when administered from the time of the development of the tumor
  • In conclusion, doxycycline greatly reduced tumor burden and could also compensate for the increased bone resorption frequently associated with bone metastasis from breast cancer
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    doxycycline useful in breast cancer animal model to reduce tumor burden through inhibition of tumor cell proliferation and inhibition of MMP.
Nathan Goodyear

Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties ... - 0 views

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    IN men with low Testosterone, Testosterone therapy improved trabecular bone, but not cortical bone.  Growth hormone provided no additional benefit.  This study looked at men with panhypopituitarism.
Nathan Goodyear

Low Vitamin D Status Has an Adverse Influence on Bone Mass, Bone Turnover, and Muscle S... - 0 views

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    normal versus low vitamin D in adolescent girls is found to be associated with increased grip strenght and lower bone turnover with increased bone mass.
Nathan Goodyear

Zoledronic acid in the management of metastatic bone disease - 0 views

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    zometa useful in treatment of metastatic bone disease for purpose of prevention of pathological fractures and treatment of bone pain.
Nathan Goodyear

Bariatric Surgery Results in Cortical Bone Loss - 0 views

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    no surprise here.  Bariatric surgery was found to result in bone loss.  Disruption of the GI tract and absorption is going to result in malnutrition states and bone loss will be one of the side effects.
wheelchairindia9

Tynor Wrist and Forearm Splint Right-Left - 0 views

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    Tynor Wrist and Forearm Splint Right-Left Wrist and Forearm Splint is designed to immobilize and provide firm and comfortable support to hand and wrist in various orthopedic conditions. It maintains the wrist in the functional position. Aesthetically appealing. Customizable splint. Perfect immobilization. Controlled compression. Anatomical thumb opening. Tynor Wrist and Forearm Splint Right-Left Features Made out of PUF fused Matty fabric Breathable Excellent aesthetics Improved comfort Enhanced life. Removable, Aluminum Splints Customized fitting Required degree of dorsi-flexion can be achieved Very good grip and immobilization Design features Long length of the brace, ensures enhanced immobilization Brace abuts the Palmer crease , allows free finger movement. Elegant tabs , allow easy application and removal Elegant tabs, also enhance the aesthetics of the product. Black Color, enhances the aethetics Hook loop closures Easy to apply and remove Ensures optimal compression , Built in opening for thumb abduction Better pain relief and healing. Thumb remains relaxed, no fatigue Improves comfort Tynor Wrist and Forearm Splint Right-Left Measurements Measure the Circumference at a distance 6" from the wrist along the arm
Nathan Goodyear

Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a D... - 0 views

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    Gastric Bypass leads to bone loss; through malabsorption
Nathan Goodyear

Low testosterone levels are associated with poor peripheral bone mi... - PubMed - NCBI - 0 views

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    low Testosterone as defined by levels < 300 was found to be associated with bone loss in aging men.
Nathan Goodyear

Imaging of bone metastasis: An update - 0 views

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    Great review of imaging for bone metastasis.
Nathan Goodyear

The effect of calcium supplementation on bone loss... [Osteoporos Int. 2009] - PubMed r... - 0 views

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    calcium supplementation slows bone loss; but benefits lost after 4 years
Nathan Goodyear

Bone Loss in Adolescents After Bariatric Surgery -- , 10.1542/peds.2010-0785d -- Pediat... - 0 views

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    Weight loss surgery in teens results in bone loss; long-term implications is very poor
wheelchairindia9

Tynor Rib Belt - 0 views

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    Tynor Rib Belt Rib belt is applied to the thoracic and upper abdominal region to compress and bind the rib cage during rib fractures and postoperative care, while allowing sufficient flexibility for comfortable breathing. Extra porous. With splinting pad. No buckling or rolling over. Controlled compression. Tynor Rib Belt Features Light weight and thin construction, does not peep through the clothes improves patient compliance. Extra porous webbing improves ventilation and comfort of the patient. Broad hook and loop tape panel offers better holding and size adjust ability. Optimal compression, tones up abdominal muscles following surgery, CS or delivery. Special nylon reeves prevent rolling over of belt. Tynor Rib Belt Measurements Measure circumference around the chest.
Nathan Goodyear

Waldenstrom's macroglobulinemia presenting with lytic bone lesions: a rare presentation - 0 views

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    Waldenstrom's macroglobulinemia with osteolytic bone lesions.
Nathan Goodyear

Waldenstrom's Macroglobulinemia Associated Bone Disease the UAMS Experience | Blood Jou... - 0 views

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    waldenstrom's macroglobulinemia found to have 24% bone disease.
Nathan Goodyear

Lytic Bone Lesions as a Prominent Feature in Waldenstrom's Macroglobulinemia. - PubMed ... - 0 views

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    Waldentstrom's macroglobulinemia with lytic bone lesions.  Only abstract available here.  Treatment, other than chemo, is radiation to effected site.
fnfdoc

Symptoms Of Aplastic Anemia | Your Health Our Priority - 0 views

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    Aplastic Anemia is a rare but serious disease of the blood cells. It is diagnosed by the inability of the bone marrow to synthesize RBCs, WBCs and platelets. The spongy bone marrow contains stem cells that are actively involved in Hematopoiesis.
Nathan Goodyear

Cancers | Free Full-Text | Integrin αvβ3 Signaling in Tumor-Induced Bone Disease - 0 views

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    Integrin αvβ3 increased and involved in bone metastasis
Nathan Goodyear

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23... - 0 views

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    high leptin, high PTH, fibroblastic growth factor, and bone alkaline phosphatase associated with obesity.
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