review study of 263 studies finds no association between LDL and mortality in elderly. In fact, the review found an inverse association between LDL and mortality i.e. increasing LDL associated with lower mortality in elderly.
The microbiota of the large intestine plays an important role in host metabolism and
maintenance of host health
Our results defining a standard adult profile, together with previous reports, showed
that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
In infant fecal microbiota, we observed Bifidobacterium as the dominant group
this observation is strongly related to diet, being enhanced by breast
feeding
Significant higher numbers
of Bifidobacterium were observed in infants versus adults and seniors
the gastrointestinal tract
is first colonized by facultative anaerobes, such as E. coli
Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
diet
change must be considered among the primary causes for such a shift of microbiota
between infants and adults.
In the case of elderly subjects, our qPCR results indicated a significant increase
in the counts of E. coli when compared to adults. This data is consistent with other publications indicating
that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
a number of authors reported a reduction
in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota
status
Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those
obtained by Ley et al
Compared with young adults, the elderly have a different digestive physiology, characterized
at a physiological level by a reduction in transit and of digestive secretions
The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced
age
Good discussion of the gut microbiome. Age effects the gut bacteria balance. The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study. Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
low vitamin D and PTH in black and white elderly associated with increased mortality; however, the black elderly have lower vitamin D levels in comparison to their white counterparts. How does this play a in increased advanced disease? I believe quite a bit.
Testosterone given to elderly men with low "serum" testosterone shown to increase IGF-1 and increased muscle growth and strength. So, this study shows that testosterone in men, seems to increase HGH production and thus increase IGF-1 production. This may be the mechanism by which testosterone promotes muscle growth and increase in strength in men.
Those men with higher estradiol levels found to have increased stroke risk. This study only looked at elderly men > 71. This should come as no surprise as E2 in men is know to increase inflammatory signaling.
Even back in 1980, DHT metabolism was known. Elderly men, 3alpha oxidoreductase is decreased resulting in decreased DHT to 3-alpha-diol. This study discussed the DHT metabolite as inactive. We now know that is not the case.
This study points to an association between a low-normal TSH and cognitive decline in the elderly. An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit. The results of this study do as well.
Study found no significant effect of subclinical hypothyroidism on weight in the elderly. However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Commode chairs are best suited for people who cannot use a regular toilet. The chairs enable patients who have limited mobility due to an accident or any medical condition to use the toilet with ease. The chair allows the patient to use the toilet without causing discomfort to the legs and back. The chair can be used by people who are restricted to a bed or wheelchair. A commode chair is a useful mobility for people of any age who are recovering from injury or surgery. The chair offers a reasonable level of independence to the user; a handy device to be presented to someone who needs it and for whom care. Commode Wheelchairs which are specially designed for aged and physically challenged people. These wheelchairs can be used for indoor toilet purposes. Fabricated using quality raw material, these wheelchairs are suitable for domestic and hospital purpose.
There are two types for handicapped and disability product like Commode Wheelchair-
Commode Wheelchair Rainbow 6
Commode Wheelchair Rainbow 7
Commode Wheelchair Rainbow 6:
Karma commode wheelchair rainbow 6 comes with lot of exiting features for elderly or physically challenged person who want commode in wheelchair. Karma Rainbow 6 has single seat with center cut commode having cushion cover on top and removable pan or plastic commode seat with pot.
Commode Wheelchair Rainbow 6 Features:
Frame Material : M.S.Chrome Plated
Single Seat with center cut commode
Both Option Available In Single Seat
Plastic Commode Seat With Pot.
Cushioned Top Cover
Square Pan Commode Pan
Removable Pan
Commode Wheelchair Rainbow 6 Measurements:
Frame Style : Foldable
Open Position Wheel To Wheel Width In : 26" (Inches)
Seat Width : 18" (Inches)
Total Width in Closing Position : 11" (Inches)
Rear Wheel Size : 24" (Inches)
Front Wheel Size : 8" (Inches)
Seat to Floor Height : 19" (Inches)
Seat Depth : 18" (Inches)
Total Height : 34" (Inches)
Max User Weight Capacity : 110 (kgs)
The benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins.
obesity, but also impaired general health, are the more common causes of low testosterone in aging men
Severe LOH is associated with substantially higher risks of all-cause and cardiovascular mortality,
advanced age, obesity, a diagnosis of metabolic syndrome, and poor general health status were predictors of LOH
Diabetes mellitus was correlated with hypogonadism in most studies
coronary heart disease, hypertension, stroke, and peripheral arterial disease did not predict hypogonadism, they did correlate with the incidence of low testosterone
LOH can be defined by the presence of at least three sexual symptoms associated with a total testosterone level of less than 11 nmol/L (3.2 ng/mL) and a free testosterone level of less than 220 pmol/L (64 pg/mL)
the European Male Aging study defined low T as total < 320 ng/dl and free < 64 pg/ml.
Mean weight decreased
Waist circumference decreased
Total cholesterol decreased
Low-density lipoprotein decreased
Triglycerides decreased
High-density lipoprotein (HDL) increased
ratio of total cholesterol to HDL improved
Prostate volume increased
PSA increased
The benefits for men older than 65 years of age were compared with those of younger men, and the improvements in body weight, metabolic factors, psychological functioning, and sexual functioning were of the same magnitude in both age groups
weight loss was progressive over the 6-year period, effects of testosterone on lipids and on psychological and sexual functioning reached a plateau after approximately 3 years and these effects were sustained
Effects of testosterone on hematopoiesis, on the prostate, and on bladder function were not more severe in older men than in younger men
observe a mild increase in prostate volume and serum PSA over time, which is a normal finding in aging men. Maybe somewhat surprising, postvoiding residue and the IPSS did not deteriorate with aging but showed a degree of improvement
the severity of the metabolic syndrome is associated with the severity of lower urinary tract symptoms
The symptoms of the metabolic syndrome improve upon testosterone treatment and testosterone may thus have a favorable effect on lower urinary tract symptoms
it seems reasonable to conclude that the risks of testosterone administration to elderly men are not disproportionately higher in elderly men than in younger men.
Despite evidence to the contrary, physicians still harbor a wrongful association between testosterone and the development of prostate pathology (prostate cancer and benign prostate hyperplasia)
Not surprisingly, the incidence of prostate cancer was higher in older men; however, it was lower than expected in both groups
These observations suggest that the incidence of prostate cancer in patients receiving testosterone therapy, both in the younger and in the older group, was not greater than in the general population not receiving testosterone treatment
The historical fear that raising testosterone levels will result in more prostate cancer has been dispelled, particularly by the work of Abraham Morgentaler
Higher serum testosterone levels fail to show an increased risk of prostate cancer, and supraphysiological testosterone does not increase prostate volume or PSA in healthy men
This apparent paradox is explained by the "saturation model,"
Recent studies indicate no increased risk of prostate cancer among men with serum testosterone in the therapeutic range
In the present observational study, no cases of major adverse cardiovascular events occurred.
the benefits of testosterone therapy are fully achieved only by long-term treatment
To achieve maximal benefits, good patient adherence is a prerequisite
This study found that high serum testosterone associated with a reduction of cardiovascular events in elderly men. Studies have shown that low T is associated with increased cardiovascular mortality and in cardiovascular events, but this study takes it one step further: testosterone reduces those risks.