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Nathan Goodyear

Regenerative potential for allopregnanolone - 0 views

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    Progesterone and allopregnanolone shown to have neuroprotective and neurogenesis properties in the brain. BDNF was positively correlated with progesterone. So as women age, progesterone falls, as progesterone falls, then BDNF falls and neuroplasticity declines and thus we see neurodegenerative disorders. And hormones are not needed? Who are these scientists that don't read research?!
Nathan Goodyear

Fall prevention using olfactory stimulation... [J Am Geriatr Soc. 2012] - PubMed - NCBI - 0 views

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    Lavender essential oil for elderly shown to reduce falls.
Jadibuti jadibuti.net

Home Remedies for Hair Growth - 0 views

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    What is Hair Loss? Hair loss, also known as Alopecia or baldness, is a loss of hair from the head or body. Hair loss happens when frequent falling of hair results in thinning of the hair in the scalp. Losing hair fast may not only be a disease ...
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    What is Hair Loss? Hair loss, also known as Alopecia or baldness, is a loss of hair from the head or body. Hair loss happens when frequent falling of hair results in thinning of the hair in the scalp. Losing hair fast may not only be a disease ...
Nathan Goodyear

http://www.andrologyjournal.org/cgi/rapidpdf/jandrol.112.016386v1.pdf - 0 views

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    This study looked at T:E2 levels in men for seasonal fluctuations.  What is interesting, is that the T:E2 ratio is at it's lowest during the fall months and highest during the summer months.  This does conflict somewhat with studies that have looked at seasons fluctuations of T alone.  But, it does correlate with changes in body habitus and activity levels.
Nathan Goodyear

Seasonality, waist-to-hip ratio, an... [Psychoneuroendocrinology. 2006] - PubMed - NCBI - 0 views

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    another article discusses the seasonal variation of testosterone.  Again, testosterone levels are shown to be highest in the fall months and lowest during the summer months.  This has been found to be the case in both sexes.
Nathan Goodyear

Seasonal variation of salivary testosterone in... [Physiol Behav. 2011] - PubMed - NCBI - 0 views

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    interesting study that showed that testosterone levels in men and women fluctuate seasonally.  The highest levels are found in the fall for both sexes, but lowest during the summer.  Interestingly, birth control eliminated these seasonal variations and resulted in a "flatter seasonal testosterone profile".   So, maybe mean cycle, but on a much different time scale?  Interesting thought.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

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    Testosterone levels fluctuate seasonally, with the peak production in the fall of the year.  Contrast that with LH, with it's peak in the spring of the year.  This study found that men with Klinefelter's syndrome had only seasonal fluctuations of testosterone, suggesting a testicular independent role.  This is a small study.  
Nathan Goodyear

A Vitamin B-12 Supplement of 500 μg/d for Eight Weeks Does Not Normalize Urin... - 0 views

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    current vitamin B12 recommendations are too low.  Proper vitamin B12 biomarker testing reveals this fact. The problem is most people fall prey to the lack of knowledge behind simple serum levels.  Simple B12 serum levels are woefully inadequate. Insurance would rather one stay with inadequate testing to save money, rather than actually read the science to learn about new testing.
Nathan Goodyear

The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implicat... - 0 views

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    discussion of the declining levels of androgens in the aging male.  But the focus of this entire article is wrong.  They are focusing on the blood levels of these androgens.  The biological effects of hormones occur in tissue not blood.  Though this article provides a good discussion of how transport of androgens are effected, it falls far short of providing any useful clinical application, because it fails to discuss peripheral levels of androgens.  
Nathan Goodyear

Testosterone and Visceral Fat in Midlife Women: The Study of Women's Health Across the ... - 0 views

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    New study, SWAN study, finds that bioavailable Testosterone was "significantly positively related" to visceral fat.  As bioavailable Testosterone increases in post-menopausal women, visceral fat increases.  The authors conclude that Testosterone increases visceral fat accumulation.  This increased Testosterone is concluded to be from a decrease in SHBG as a result of falling Estradiol.
Nathan Goodyear

High Estrogen in Men After Injectable Testo... [Am J Mens Health. 2014] - PubMed - NCBI - 0 views

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    Again, Testosterone and here Estradiol are merely there for libido and sex.  What tunnel vision?!  What about hsCRP?  What about fibrinogen?  What about IL-1beta?  What about TNF-alpha?  These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men.   And PSA?  No mention of it here.   This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not.  That is not a well designed study.  One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity.  Second, this was simply a retrospective chart review.  Third, a 50% conversion of 34,000 + men is very high when you look at the literature.  Fourth, they point to gynecomastia as a means of negative?  The cardiovascular implications are more significant.  These studies just seem to focus on superficial things.  Fifth, did libido problems exist before?  What were the free levels?   This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.
Nathan Goodyear

Green Tea Consumption Is Inversely Associated with th... [J Nutr. 2011] - PubMed - NCBI - 0 views

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    drink green tea to prevent the flu this fall/winter
Nathan Goodyear

Testosterone for the aging male; current evidence and recommended practice - 0 views

  • Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin −50%)
  • Testosterone binds only loosely to albumin and so this testosterone as well as free testosterone is available to tissues and is termed bioavailable testosterone
  • Testosterone bound to SHBG is tightly bound and is biologically inactive
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  • Bioavailable and free testosterone are known to correlate better than total testosterone with clinical sequelae of androgenization such as bone mineral density and muscle strength
  • peak levels seen in the morning following sleep, which can be maintained into the seventh decade
  • Samples should always be taken in the morning before 11 am
  • The reliable measurement of serum free testosterone requires equilibrium dialysis. This is not appropriate for clinical use as it is very time consuming and therefore expensive.
  • With increasing age, a greater number of men have total testosterone levels just below the normal range or in the low-normal range. In these patients total testosterone can be an unreliable indicator of hypogonadal status.
  • It is advised that at least two serum testosterone measurements, taken before 11 am on different mornings, are necessary to confirm the diagnosis.
  • Patients with serum total testosterone consistently below 8 nmol/l invariably demonstrate the clinical syndrome of hypogonadism and are likely to benefit from treatment. Patients with serum total testosterone in the range 8–12 nmol/l often have symptoms attributable to hypogonadism and it may be decided to offer either a clinical trial of testosterone treatment or to make further efforts to define serum bioavailable or free testosterone and then reconsider treatment. Patients with serum total testosterone persistently above 12 nmol/l do not have hypogonadism and symptoms are likely to be due to other disease states or ageing per se so testosterone treatment is not indicated.
  • Total testosterone levels fall at an average of 1.6% per year whilst free and bioavailable levels fall by 2%–3% per year.
  • With advancing age there is also a reduction in androgen receptor concentration in some target tissues and this may contribute to the clinical syndrome of LOH
  • Metabolic clearance declines with age
  • Gonadotrophin levels rise during aging (Feldman et al 2002) and testicular secretory responses to recombinant human chorionic gonadotrophin (hCG) are reduced
  • There are changes in the lutenising hormone (LH) production which consist of decreased LH pulse frequency and amplitude, (Veldhuis et al 1992; Pincus et al 1997) although pituitary production of LH in response to pharmacological stimulation with exogenous GnRH analogues is preserved
  • the decreases in testosterone levels with aging seem to reflect changes at all levels of the hypothalamic-pituitary-testicular axis
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    Leptin inhibits male Testosterone production at the level of the hypothalamus and at the testicle level.
star yu

How to Deal with it When Blood Pressure Falls During Dialysis - 0 views

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    "Dear, doctor. Is there natural home remedies for kidney disease, especially for Creatinine 8.1 patients. Many patients asked about what to do when blood pressure falls during dialysis and consequences of doing dialysis. My father is a CKD stage 3 and sufferer from pain on his left side between and left hip and last rib. How to alleviate it?"
finchloe121

How To Diagnose And Defeat Insomnia In An Easy Manner! - 0 views

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    Insomnia is a condition that prevents a person from getting peaceful and sound sleep for hours. It is a symptom that occurs due to various symptoms and causes. This sleep disorder affects people in different ways. If you suffer from insomnia, you may not be able to fall asleep or stay asleep. Cognitive behavioral therapy or CBT is a type of psychotherapy used to treat insomnia, anxiety disorders, depression, eating disorders, marital disorders, and quality of life. Cognitive-behavioral therapy focuses on changing individuals' negative thoughts because thoughts can primarily contribute to the construction of anxiety, depression, and emotional difficulties. Many people typically need at least 3-4 hours of sleep a night, but the average sleep time is 6-9 hours. This means that sleep duration and sleep cycles vary from person to person. The most important thing is to get enough sleep, no matter how long it takes. The best remedy to treat the symptoms of this disorder is to use OTC Zolpidem 5mg Tablets Online.
finchloe121

Insomnia What You Know and What You Don't! - 0 views

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    Most of you would know that insomnia is a sleep problem, and it causes difficulty in falling asleep and staying asleep for a reasonable amount of time. It also affects sleep quality, resulting in daytime inactivity. Most of the time, insomnia can become long-term. This long-term insomnia is called chronic insomnia. This type of insomnia is diagnosed when the patient has trouble sleeping, at least 3 to 4 days a week for at least one month. Acute insomnia or short-term insomnia is the most common type of insomnia that most people have today. As the name suggests, it is a short-term illness and lasts only for a few days or at most three to four weeks. Consult your doctor, get a proper check-up, explain all the problems including your sleep schedule. Initially, severe insomnia symptoms may not require adequate treatment. If a person feels tired and cannot perform his physical activities during the day, he should buy sleeping pills for a short time as per the prescription of his doctor or physician. If your symptoms are not under control, use cheap Temazepam 10 mg tablets available online. You can buy these insomnia pills online from Pharma Health Online.
Nathan Goodyear

Does increased aromatase activity in adipose fibroblasts cause low sexual desire in pat... - 0 views

  • high oestrogen levels in men do not necessarily result in a fall in androgen levels
  • These high oestrogen levels, therefore, seem capable of decreasing sexual libido and lowering sexual activity
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    Increased aromatase activity and resultant estrogen production negatively effects libido in HIV men.  I don't believe that this effect is just found in those with HIV, but can be extrapolated to all.
Nathan Goodyear

The endocrinology of sexual arousal - 0 views

  • A number of age-related changes may be relevant: altered negative feedback of testosterone and hence less increase in luteinizing hormone (LH) with falling testosterone levels, increased sex hormone binding globulin (SHBG) and hence relatively reduced free testosterone and the likelihood of an age-related decline in testosterone receptor sensitivity
  • In the older male, the picture is complicated by various aging effects, including altered hypothalamo–pituitary feedback, increased testosterone binding and reduced receptor sensitivity
  • The neurophysiological basis of NPT is still disputed, but one plausible explanation is that REM sleep is associated with a ‘switching off’ of the noradrenergic cells in the locus coeruleus
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  • the impact of testosterone on the emergence of sexual arousability is less clear
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    Good discussion of the arousal/sexual response differences between men and women from a physiological perspective.  
Nathan Goodyear

Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms ... - 0 views

  • WHt ratio was calculated by dividing waist (cm) by height (cm)
  • nverse relationships of BMI and WC with TT and cFT have been previously documented in unselected cohorts of adult men
  • over the age of 54 years
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  • adjusting WC for height (WHt ratio) improves the prediction of TT and cFT compared with either BMI or WC alone
  • there were inverse correlations between cFT, TT and either BMI or WC
  • for each unit increase in BMI, there was a 2% fall in TT and cFT
  • for each 10 cm increment in WC, TT and cFT levels declined by 7%.
  • The magnitude of this relationship between increasing BMI and decreasing TT is similar to that described in the Massachusetts Male Ageing Study
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    waist to height ratio reliable predictor of low T in men.
Nathan Goodyear

Testosterone for secondary prevention in men with ischaemic heart disease? - 0 views

  • Androgens and in particular testosterone have an inverse relationship with fibrinogen such that low endogenous testosterone is associated with elevated fibrinogen
  • testosterone administration causes a significant fall in fibrinogen
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    this article looks at the use of normalization of testosterone levels in men with CAD.  This study presents the data that low T is associated with increased CAD, yet says more studies needed.  This study should have used salivary testing and been more definitive in their conclusion
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