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Nathan Goodyear

Low free testosterone is associated with loss of appendicular muscle mass in Japanese c... - 0 views

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    low Free testosterone found to be associated with muscle mass loss in women when compared to high free Testosterone levels.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

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    Study finds low free Testosterone and low calculated free Testosterone was associated with sarcopenia in Japanese men.  This association was not found with Total Testosterone.
Nathan Goodyear

Muscle Mass Index As a Predictor of Longevity in Older Adults - The American Journal of... - 0 views

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    Higher muscle mass associated with lower mortality in older adults.  so many focus on cardio and forget about resistance training.
Nathan Goodyear

Testosterone restores insulin sensitivity in patients with diabetes and hypogonadism | ... - 0 views

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    This is the abstract from oral presentation at AACE in Las Vegas from May.  Small study finds reduction in fat mass, increase in muscle mass, increase in insulin sensitivity, and reduction in inflammation signaling with Testosterone therapy in men with low Testosterone.  These men were type 2 diabetics.  This is consistent with prior published literature.  However, men without diabetes, this association is hard to reproduce. The degree of glucose control also effects the response to Testosterone therapy i.e. the worse the glucose control, the more the response from Testosterone.  

    Also of note, those men with hypogonatrophic hypogonadism had decreased insulin receptor expression, decreased insulin sensitivity, and decreased GLUT-4 expression versus eugonadal men.  Remember from prior studies, it is the conversion of Testosterone to DHT that increases GLUT-4 transcription, translocation, and expression.
Nathan Goodyear

Effect of Testosterone Treatment on Glucose Metabolism in men With Type 2 Diabetes: A R... - 0 views

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    Study finds no improvement with glucose control in diabetics.  This study looked at moderately controlled diabetes. Studies have previously shown that poorly controlled diabetes definitely benefits more than those with more mild glucose control problems.  Additionally, the Testosterone levels in this study would not have met the definition of low T by other studies.  So, the question is did these men need T?  Second, did the authors design the study long enough to see changes in the insulin sensitivity and glucose control?  Abstract only available and thus I don't have access to that information.  Third, and this might support the 2nd point, increased lean mass and decreased fat mass was found.  This points to positive metabolic change.  Would this have, given more time, resulted in improved glucose control?

    No change in visceral adiposity was seen.  This finding, also, is not new.  Testosterone therapy does not improve visceral adiposity.  Though, increasing fat adiposity, low Testosterone, and associated increase in systemic inflammatory cytokine production results in visceral adiposity, Testosterone therapy does reverse the visceral adiposity.  
Nathan Goodyear

Dehydroepiandrosterone supplementati... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

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    meta-analysis finds reduction in fat mass from DHEA in elderly men.  The authors propose that it is due to the conversion to other hormones.  
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in No... - 0 views

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    Study finds that massive doping of Testosterone, 600 mg weekly, results in increase muscle mass and performance with strength training.  This dosing amounts to about 100 mg daily compared to the 5-10 mg of peak daily production of a young man.
Nathan Goodyear

Changes in fat and lean body mass during androgen-de... [Urology. 2004] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy resulted in an 11% increase in fat mass and just under 4% decrease in lean muscle mass in men.  
Nathan Goodyear

Changes in body composition during a... [J Clin Endocrinol Metab. 2002] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy was found to decrease lean muscle mass and increase abdominal adipose tissue, not visceral.  Significant change in body composition in men depleted of androgens in androgen deprivation therapy.
Nathan Goodyear

Does systemic low-grade inflammation... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Increased fat mass in per pubertal girls is associated with inflammation.  This study evaluated inflammation via hsCRP
Nathan Goodyear

Testosterone administration to elderly men increases skeletal muscle strength and prote... - 0 views

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    Testosterone given to elderly men with low "serum" testosterone shown to increase IGF-1 and increased muscle growth and strength.  So, this study shows that testosterone in men, seems to increase HGH production and thus increase IGF-1 production.  This may be the mechanism by which testosterone promotes muscle growth and increase in strength in men.
Nathan Goodyear

Counteracting muscle wasting in HIV-infected individuals - 0 views

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    HIV/AIDS patients are plagues with muscle loss through varying mechanism. This article discusses the various contributors to the muscle mass found in these men. However, this can be applicable to other men with chronic muscle loss, low T, HGH deficiency...
Nathan Goodyear

Radioimmunoassay and Tandem Mass Spectrometry Measurement of Bedtime Salivary Cortisol ... - 0 views

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    LC-MS/MS shown to be reliable in salivary cortisol evaluation.  Obese individuals create special challenges with regards to coritsol levels, due to peripheral cortisol to cortisone conversion.  

    This study points out that saliva should not be used solely in the diagnosis of Cushing's syndrome due to unreferenced norms.   That however, doesn't nullify salivary cortisol.  It requires a look at the references.  for those that are obese and being evaluated for cushing's.  There is no perfect test.  T

    This study is a little misleading in its conclusion.  Salivary testing is valid, but the reference ranges in the obese with suspected cushing's syndrome needs further evaluation: according to these authors.
Nathan Goodyear

Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Assay for Simultaneous Measur... - 0 views

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    MS-LS show to be highly sensitive in the dual identification of testosterone and cortisol in saliva. These hormones were found to be stable up to 28 days at room temperature. This disproves the argument that saliva, as a test medium, has a very short shelf life.
Nathan Goodyear

ScienceDirect.com - Journal of Chromatography B - Simultaneous determination of salivar... - 0 views

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    LC-MS for salivary testosterone and DHEA validated.  Also, T and DHEA were shown to have specific diurnal rhythms.  Changes in levels were also followed after DHEA therapy.
Nathan Goodyear

Comparison of Liquid Chromatography-Tandem Mass Spectrometry, RIA, and ELISA Methods fo... - 0 views

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    Mass Spectrometry better than RIA and ELISA for urinary estrogen metabolite testing.
Nathan Goodyear

Higher Testosterone Levels Are Associated with Less Loss of Lean Body Mass in Older Men - 0 views

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    Testosterone shown to slow loss of lean body mass, also known as muscle.
Nathan Goodyear

SpringerLink - Amino Acids, Volume 39, Number 2 - 0 views

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    L-Arginine stimulates mitochondrial function, resulting in fat loss and increase muscle mass
Nathan Goodyear

The effects of exercise training on fat-mass loss ... [Sports Med. 2007] - PubMed result - 0 views

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    exercise increases muscle mass
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