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Nathan Goodyear

Subclinical hypothyroidism in young women with... [Fertil Steril. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23103018

PCOS polycystic ovarian syndrome hypothyroid hypothroidism functional hypothyroidism women female hormone hormones

shared by Nathan Goodyear on 14 May 14 - No Cached
  • Nathan Goodyear on 14 May 14
     
    Link exists between PCOS and subclinical hypothyroidism.  Another term is functional hypothyroidism.
Nathan Goodyear

Effect of Levothyroxine Replacement on Lipid Profile and Intima-Media Thickness in Subc... - 0 views

jcem.endojournals.org/...2099.long

levothyroxin subclinical hypothyroidism functional hypothyroidism hypothyroid lipids hypothyroidism cholesterol metabolism thyroid IMT

shared by Nathan Goodyear on 27 Jul 13 - No Cached
  • Nathan Goodyear on 27 Jul 13
     
    synthetic T4, as levothyroxine, in subclinical hypothyroidism is shown to improve cholesterol levels and intima-media thickness.
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

press.endocrine.org/...jc.2011-1329

T4 T3 hypothyroid hypothyroidism thyroid lipids weight loss metabolism cholesterol hormones

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • tissue euthyroidism is the net result of multiple steps including conversion of the prohormone T4 into its active metabolite T3, which is ultimately responsible for signaling at the end-organ target level
  • The circulating and intracellular pools of T3 of treated hypothyroid patients (i.e. devoid of endogenous TH production) depend entirely on the conversion of exogenous l-T4 into T3
  • TH is the major regulator of basal metabolic rate
  • ...8 more annotations...
  • The substitution of l-T3 for l-T4 caused a significant weight loss
  • The substitution of l-T3 for l-T4 caused a significant reduction in lipid parameters
  • Despite the increase in serum T3, the l-T3 treatment did not cause major changes in cardiovascular or musculoskeletal function, as indicated by the echocardiographic and maximal exercise tolerance tests and DXA studies.
  • The changes in serum lipid metabolism parameters are similar to the effects observed with drugs approved for the treatment of dyslipidemia
  • This differential response appears to be limited to the lipid metabolism and SHBG, whereas no differences in indices of insulin resistance were detected. This is remarkable because hyperthyroid states are associated with an increase in hepatic gluconeogenesis (37), and overt thyrotoxicosis is a known cause of secondary diabetes.
  • TH action is increased in the liver, and the SHBG increase supports this hypothesis
  • Similarly, no significant differences were observed in blood pressure, heart rate, or endothelial vascular function
  • In conclusion, the results of this pharmacology, proof-of-concept study indicate that replacement therapy of hypothyroidism with l-T3, compared with l-T4 causes weight loss and favorable changes in the lipid profile without appreciable side effects
  • Nathan Goodyear on 24 Sep 14
     
    Crossover study finds T3 versus T4 results in more weight loss, improved lipid management and increased SHBG without any adverse cardiovascular effects.   The T3 was dosed 3 x daily due to its short half life compared to T4.
Nathan Goodyear

Brazilian Journal of Medical and Biological Research - Is the infertility in hypothyroi... - 0 views

www.scielo.br/scielo.php

functional hypothyroidism prolactin elevated gonadotropins infertility LH FSH

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    functional hypothyroidism associated with elevated prolactin levels and thus gonadotropin dysfunction and infertility
Nathan Goodyear

Effects of thyroxine as compared with thyroxine pl... [N Engl J Med. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9971866

T3 T4 hypothyroidism armour thyroid USP

shared by Nathan Goodyear on 19 Nov 10 - No Cached
  • n patients with hypothyroidism, partial substitution of triiodothyronine for thyroxine may improve mood and neuropsychological function;
  • Nathan Goodyear on 19 Nov 10
     
    Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

jcem.endojournals.org/...6403

hormone thyroid concentrations rT3 reverse T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
  • Nathan Goodyear on 08 Mar 11
     
    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
Nathan Goodyear

Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US nati... - 0 views

www.bmj.com/bmj.i6865

thyroid disease thyroid functional hypothyroidism hypothroidism fertility infertility

shared by Nathan Goodyear on 13 Mar 17 - No Cached
  • Nathan Goodyear on 13 Mar 17
     
    Thyroid therapy in women with subclinical hypothyroidism found to have improved pregnancy rates (lower pregnancy loss).
Nathan Goodyear

Informa Healthcare - Gynecological Endocrinology - 23(5):279 - Summary - 0 views

informahealthcare.com/...09513590701259542

functional hypothyroidism TSH infertility

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    functional hypothyroidism associated with infertility.  Thyroid evaluation doesn't end with TSH.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

press.endocrine.org/...jc.2013-3385

TSH cognition dementia elderly aging brain hormone hormones functional hypothyroidism

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

Articles - TSH, temperature, pulse rate, and other indicators in hypothyroidism - 0 views

www.doctorsaredangerous.com/...TSH.htm

Hypothyroid hypothyroidism thyroid functions TSH

shared by Nathan Goodyear on 14 Mar 11 - No Cached
  • Nathan Goodyear on 14 Mar 11
     
    long. But great post on the dynamics of thyroid function.  Linear thinking can not apply
Nathan Goodyear

Elevated Serum Thyrotropin in Thyroxine-Treated Patients with Hypothyroidism Given Sert... - 0 views

www.nejm.org/...NEJM199710023371415

zoloft SSRI hypothyroid hypothyroidism

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • Nathan Goodyear on 20 Dec 10
     
    zoloft lowers thyroid function
Nathan Goodyear

Metabolic Effects of Liothyronine Therapy in Hypothyroidism: A Randomized, Double-Blind... - 0 views

jcem.endojournals.org/...3466.abstract

T3 T4 hypothyroid hypothyroidism functional armour thyroid cholesterol LDL weight-loss overweight obesity metabolic effects therapy

shared by Nathan Goodyear on 08 Dec 11 - No Cached
  • Nathan Goodyear on 08 Dec 11
     
    T3 shown increase weight loss, lower LDL, decrease apolipoprotein B, decrease T cholesterol versus T4.  This flies in the face of conventional medical dogma, that T 4 (synthroid, levothyroxine) is the only route of thyroid replacement.  In fact, this suppports the use of armour thyroid, a T4/T3 combination.
Nathan Goodyear

Thyroid Disease and the Heart -- Klein and Danzi 116 (15): 1725 -- Circulation - 0 views

circ.ahajournals.org/...1725

thyroid T3 heart cardiovascular hypothyroid hypothyroidism

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • The importance of the recognition of the effects of thyroid disease on the heart also derives from the observation that restoration of normal thyroid function most often reverses the abnormal cardiovascular hemodynamics
  • Nathan Goodyear on 01 Feb 11
     
    T3 and normalization of thyroid function improves heart function in those with significant heart disease
Nathan Goodyear

Assessment of thyroid function during ... [Clin Endocrinol (Oxf). 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19094075

Hashimoto's thyroiditis hypothyroid hypothyroidism autoimmune disease thyroid hormone hormones inflammation

shared by Nathan Goodyear on 28 Aug 13 - No Cached
  • Nathan Goodyear on 28 Aug 13
     
    Hashimoto's Thyroiditis can show variability in thyroid function.
Nathan Goodyear

Small Differences in Thyroid Function May Be Important for Body Mass Index and the Occu... - 0 views

press.endocrine.org/...jc.2004-2225

Thyroid hypothyroid hypothyroidism hormone hormones BMI metabolism obesity weight

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Even small movements of thyroid function within the "reference rage of normal" is associated with significant metabolic, BMI, and weight effects.
Nathan Goodyear

Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodi... - 0 views

www.eje-online.org/...559

hypothyroid hypothyroidism thyroid inflammation cytokines proinflammatory

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    inflammation inhibits thyroid function
Nathan Goodyear

Thyroid Function Tests and Mortality in Aged Hospitalized Patients: A 7-Year Prospectiv... - 0 views

jcem.endojournals.org/...4683.abstract

free T3 fT3 hypothyroid hypothyroidism T3 mortality cardiovascular disease thyroid function

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Nathan Goodyear on 11 Dec 13
     
    Here is an interesting finding:  low free T3 is significantly associated with increased cardiovascular and all-cause mortality in 7 prospective study on hospitalized patients.
Nathan Goodyear

Subclinical hypothyroidism ... [Eur J Obstet Gynecol Reprod Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24768234

LDL cholesterol lipids PCOS polycystic ovarian syndrome TSH thyroid hypothyroid women female hormone hormones

shared by Nathan Goodyear on 14 May 14 - No Cached
  • Nathan Goodyear on 14 May 14
     
    Women with PCOS need a closer follow of their thyroid function.  TSH positively correlated with increasing LDL.
Nathan Goodyear

Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application - 0 views

www.ncbi.nlm.nih.gov/...PMC3134399

T3 cardiovascular death disease heart health MI myocardial infarction CHF heart failure thyroid hormone hormones hypothyroid hypothyroidism CVD

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • Nathan Goodyear on 24 Sep 14
     
    Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.
Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351

T3 hypothyroid hypothyroidism cardiac disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • In DC patients, short-term synthetic L-T3 replacement therapy significantly improved neuroendocrine profile and ventricular performance
  • Nathan Goodyear on 01 Feb 11
     
    T3 provides significant improvement in cardiac function in those with dilated cardiomyopathy
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