Group items tagged OPPOSITION - Dr. Goodyear

Methadone induces testosterone suppression in patients with opioid addiction : Scientif... - 0 views

www.nature.com/...srep06189.html

Testosterone methadone opiates low T low Testosterone men male hormone hormones women female

shared by Nathan Goodyear on 02 Sep 14 - No Cached

Nathan Goodyear on 02 Sep 14

Methadone use in men is associated with significant reduction in serum Total Testosterone levels in men. In women, just the opposite is true, though this did not reach statistical significance. The higher the dose of methadone in men, the lower the Testosterone. The link between opiates and low T in men is very strong. This is the first that I am aware of that points to the opposite effect in women.

<div class="cArrow"> </div><div class="cContentInner">Methadone use in men is associated with significant reduction in serum Total Testosterone levels in men. In women, just the opposite is true, though this did not reach statistical significance. The higher the dose of methadone in men, the lower the Testosterone. The link between opiates and low T in men is very strong. This is the first that I am aware of that points to the opposite effect in women.</div>

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The 4-Pregnene and 5α-Pregnane Progesterone Metabolites Formed in Nontumorous... - 0 views

cancerres.aacrjournals.org/...936.long

progesterone metabolite metabolites hormone hormones 5-alpha pregnene 5-alpha pregnenes 3-alpha pregnene 3-alpha pregnenes breast cancer

shared by Nathan Goodyear on 28 Jan 14 - No Cached

Nathan Goodyear on 28 Jan 14

Good discussion of the different effects of progesterone metabolites in breast cancer cell lines (in vitro). This article focused on the biochemical balance of 5alpha pregnane: 3alpha HP. The increase in this ration promoted proliferation and metastasis, where a decreased ratio did the opposite

<div class="cArrow"> </div><div class="cContentInner">Good discussion of the different effects of progesterone metabolites in breast cancer cell lines (in vitro). This article focused on the biochemical balance of 5alpha pregnane: 3alpha HP. The increase in this ration promoted proliferation and metastasis, where a decreased ratio did the opposite</div>

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No pay, no expenses, no laws for Venezuela opposition lawmakers - Locality News - 0 views

www.localitynews.com/enezuelas-opposition-lawmakers

POWER CUTS VENEZUELA OPPOSITION LAWMAKER WORLD NEWS

shared by arunaraayala on 15 Oct 16 - No Cached

arunaraayala on 15 Oct 16

On a minor scale, congressmen say they are also being obstructed from doing their job because of lac...

<div class="cArrow"> </div><div class="cContentInner">On a minor scale, congressmen say they are also being obstructed from doing their job because of lac...</div>

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Performance of salivary cortisol in the diagnosis of Cushing's syndrome, adrenal incide... - 0 views

www.eje-online.org/...31.abstract

saliva salivary hormone hormones cortisol testing Cushing's disease Cushing's syndrome

shared by Nathan Goodyear on 25 Jun 13 - No Cached

Nathan Goodyear on 25 Jun 13

Salivary hormone testing again shown to gold standard. This study looked at salivary cortisol levels in those with Cushing's disease, Cushing's syndrome, and with adrenal incidentaloma. The results make one scratch their head. The sensitivity and specificities of salivary cortisol were very high, exceeding at least 94% with most > 96 and 97%. So, why the opposition? Ignorance I guess.

<div class="cArrow"> </div><div class="cContentInner">Salivary hormone testing again shown to gold standard. This study looked at salivary cortisol levels in those with Cushing's disease, Cushing's syndrome, and with adrenal incidentaloma. The results make one scratch their head. The sensitivity and specificities of salivary cortisol were very high, exceeding at least 94% with most > 96 and 97%. So, why the opposition? Ignorance I guess.</div>

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Evaluation of Plasma, Salivary, and Urinary Cortisol Levels for Diagnosis of Cushing's ... - 0 views

www.jstage.jst.go.jp/..._pdf

saliva salivary hormone hormones Cushing's syndrome testing

shared by Nathan Goodyear on 25 Jun 13 - No Cached

Nathan Goodyear on 25 Jun 13

Salivary cortisol shown to have "high sensitivity and specificity" in subclinical and overt Cushing's syndrome. Again, why the opposition to saliva??? Ignorance.

<div class="cArrow"> </div><div class="cContentInner">Salivary cortisol shown to have "high sensitivity and specificity" in subclinical and overt Cushing's syndrome. Again, why the opposition to saliva??? Ignorance.</div>

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Diet-hormone interactions: Protein/carbohydrate ratio alters reciprocally the plasma le... - 0 views

www.sciencedirect.com/...0024320587900865

nutrition diet carbohydrates fiber protein Testosterone men hormones male hormones cortisol

shared by Nathan Goodyear on 21 Sep 16 - No Cached

Nathan Goodyear on 21 Sep 16

small study, but complex carbs found to increase Testosterone more than high protein diet. That goes against most marketing. In contrast, cortisol was the opposite.

<div class="cArrow"> </div><div class="cContentInner">small study, but complex carbs found to increase Testosterone more than high protein diet. That goes against most marketing. In contrast, cortisol was the opposite.</div>

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11-Ketotestosterone Is a Major Androgen Produced in Human Gonads: The Journal of Clinic... - 0 views

press.endocrine.org/...jc.2016-2311

testosterone 11-ketotestosterone hormones

shared by Nathan Goodyear on 17 Oct 16 - No Cached

Nathan Goodyear on 17 Oct 16

Only abstract available here; 11-ketotestosterone found not to be susceptible to aromatase activity as is testosterone. This was a breast cell culture study. It was found to actually inhibit cell proliferation in opposition to aromatized testosterone.

<div class="cArrow"> </div><div class="cContentInner">Only abstract available here; 11-ketotestosterone found not to be susceptible to aromatase activity as is testosterone. This was a breast cell culture study. It was found to actually inhibit cell proliferation in opposition to aromatized testosterone.</div>

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Validation of salivary testosterone as a screening test for male hypogonadism - 0 views

www.cenegenicsfoundation.org/...test_for_male_hypogonadism.pdf

saliva salivary testosterone hormone hormones men male

shared by Nathan Goodyear on 14 Aug 12 - No Cached

Nathan Goodyear on 14 Aug 12

This study reviewed two studies and both validated salivary testosterone as a method of testing. The statistical significance was very high. Additionally, they found a 47% decline in testosterone over the study lifespan of a man. So, again, what is the opposition to saliva testing? The only thing I can think of is resistance to change and/or lack of education. As a scientist, neither is acceptable.

<div class="cArrow"> </div><div class="cContentInner">This study reviewed two studies and both validated salivary testosterone as a method of testing. The statistical significance was very high. Additionally, they found a 47% decline in testosterone over the study lifespan of a man. So, again, what is the opposition to saliva testing? The only thing I can think of is resistance to change and/or lack of education. As a scientist, neither is acceptable.</div>

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Endogenous sex hormones, metabolic syndrome... [Curr Cardiol Rep. 2014] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24585109

sex hormones men women Testosterone metabolic syndrome metabolic syndrome MetS diabetes SHBG

shared by Nathan Goodyear on 04 Mar 14 - No Cached

Nathan Goodyear on 04 Mar 14

Abstract ahead of print. Low Testosterone in men is associated with increased risk of metabolic syndrome and type II Diabetes. Just the opposite is the case in women: elevated Testosterone in women is associated with increasing metabolic syndrome and diabetes risk. Low SHBG is associated with increased risk in both.

<div class="cArrow"> </div><div class="cContentInner">Abstract ahead of print. Low Testosterone in men is associated with increased risk of metabolic syndrome and type II Diabetes. Just the opposite is the case in women: elevated Testosterone in women is associated with increasing metabolic syndrome and diabetes risk. Low SHBG is associated with increased risk in both.</div>

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Metabolic syndrome as a prognostic factor for breast cancer recurrences - Pasanisi - 20... - 0 views

onlinelibrary.wiley.com/...full

Testosterone women metabolic syndrome metabolic syndrome breast cancer

shared by Nathan Goodyear on 12 Mar 14 - No Cached

Nathan Goodyear on 12 Mar 14

Women with metabolic syndrome have increased recurrence of breast cancer after initial therapy. Likewise, Increasing Testosterone was associated with increasing risk of metabolic syndrome. This is the opposite of men. One wonders what this massive doping of Testosterone that is underway is doing to women? Are we merely feeding disease?

<div class="cArrow"> </div><div class="cContentInner">Women with metabolic syndrome have increased recurrence of breast cancer after initial therapy. Likewise, Increasing Testosterone was associated with increasing risk of metabolic syndrome. This is the opposite of men. One wonders what this massive doping of Testosterone that is underway is doing to women? Are we merely feeding disease?</div>

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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive ... - 0 views

www.pnas.org/...0804226105.abstract

IV vitamin C IV vitamin C cancer

shared by Nathan Goodyear on 25 Sep 13 - Cached

Nathan Goodyear on 25 Sep 13

Nice study that reveals the pharmacologic mechanism of vitamin C as a pro-oxidant in cancer cells. Obviously, this effect is opposite that found blood. In this study they looked at high dose IV vitamin C in the treatment of ovarian, pancreatic, and glioblastoma cancer. Treatment was beneficial and well tolerated.

<div class="cArrow"> </div><div class="cContentInner">Nice study that reveals the pharmacologic mechanism of vitamin C as a pro-oxidant in cancer cells. Obviously, this effect is opposite that found blood. In this study they looked at high dose IV vitamin C in the treatment of ovarian, pancreatic, and glioblastoma cancer. Treatment was beneficial and well tolerated.</div>

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Implications of adiponectin in linking metabolism ... [Endocrine. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24287788

adiponectin Testosterone hormone hormones

shared by Nathan Goodyear on 02 Dec 13 - No Cached

Nathan Goodyear on 02 Dec 13

Adiponectin is negatively associated with LH, FSH production at the level of the pituitary and Testosterone at the level of the testicle. Meaning: a risking adiponectin, as found in obesity, is associated with a down regulated HPA stimulation and Testosterone production. This study, however, found a local autocrine/paracrine effect on sperm that was quite the opposite.

<div class="cArrow"> </div><div class="cContentInner">Adiponectin is negatively associated with LH, FSH production at the level of the pituitary and Testosterone at the level of the testicle. Meaning: a risking adiponectin, as found in obesity, is associated with a down regulated HPA stimulation and Testosterone production. This study, however, found a local autocrine/paracrine effect on sperm that was quite the opposite.</div>

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Endogenous Sex Hormones and the Development of Type 2 Diabetes in Older Men and Women: ... - 0 views

care.diabetesjournals.org/...55

type II diabetes Testosterone men women risk SHBG diabetes hormone hormones

shared by Nathan Goodyear on 13 May 14 - No Cached

Nathan Goodyear on 13 May 14

A prospective study of aging men and women in the development risk of type II diabetes. The sexes bring significant differences. In men, low Testosterone predicts the development of type II diabetes. In women, just the opposite is seen--high Testosterone levels and low SHBG are most predictive of type II diabetes risk.

<div class="cArrow"> </div><div class="cContentInner">A prospective study of aging men and women in the development risk of type II diabetes. The sexes bring significant differences. In men, low Testosterone predicts the development of type II diabetes. In women, just the opposite is seen--high Testosterone levels and low SHBG are most predictive of type II diabetes risk.</div>

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Journal of Endocrinological Investigation - 0 views

www.jendocrinolinvest.it/...abstract.cfm

estradiol testosterone hormone hormones post-menopausal women

shared by Nathan Goodyear on 28 Oct 13 - No Cached

Nathan Goodyear on 28 Oct 13

endogenous, not supplemented, estradiol positively correlated with inflammation, weight, insulin resistance, and increased homocysteine. Likewise Testosterone positively correlated with increased weight, insulin resistance, yet negatively with HDL and SHBG. This study looked at post-menopausal women. The conclusion of this study was that endogenous estradiol and Testosterone are biomarkers for CVD risk. If they are positively associated with an increased risk, then adding in extra E2 without opposition of Progesterone and Testosterone, then CVD risk is increased.

<div class="cArrow"> </div><div class="cContentInner">endogenous, not supplemented, estradiol positively correlated with inflammation, weight, insulin resistance, and increased homocysteine. Likewise Testosterone positively correlated with increased weight, insulin resistance, yet negatively with HDL and SHBG. This study looked at post-menopausal women. The conclusion of this study was that endogenous estradiol and Testosterone are biomarkers for CVD risk. If they are positively associated with an increased risk, then adding in extra E2 without opposition of Progesterone and Testosterone, then CVD risk is increased.</div>

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Obestatin partially affects ghrelin stimulatio... [Endocrinology. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17204551

obestatin overweight obesity weight loss

shared by Nathan Goodyear on 02 Nov 11 - No Cached

Nathan Goodyear on 02 Nov 11

obestatin inhibits food intake and slow GI motility. THis is the opposite of ghrelin, which increases appetite

<div class="cArrow"> </div><div class="cContentInner">obestatin inhibits food intake and slow GI motility. THis is the opposite of ghrelin, which increases appetite</div>

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Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached

Nathan Goodyear on 27 May 14

Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring. In the male offspring there appears to be an up regulation of the HPA axis. The opposite appears true in the female off spring. Additionally, the receptors are effected differently as well.

<div class="cArrow"> </div><div class="cContentInner">Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring. In the male offspring there appears to be an up regulation of the HPA axis. The opposite appears true in the female off spring. Additionally, the receptors are effected differently as well.</div>

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Expression and significance of androgen receptor coactivators in urothelial carcinoma o... - 0 views

erc.endocrinology-journals.org/...123.full

bladder cancer bladder cancer AR androgen receptor androgen receptor receptors hormones hormone androgen receptors

shared by Nathan Goodyear on 04 Jan 15 - No Cached

Nathan Goodyear on 04 Jan 15

This study focused on coactivators in bladder cancer. Although, the study found that AR expression was inversely associated with advancing bladder cancer stage--This is opposite from the positive correlation with Prostate Cancer.

<div class="cArrow"> </div><div class="cContentInner">This study focused on coactivators in bladder cancer. Although, the study found that AR expression was inversely associated with advancing bladder cancer stage--This is opposite from the positive correlation with Prostate Cancer. </div>

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Association Between Endogenous Sex Hormones and Liver Fat in a Mult... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25592661

Testosterone Estradiol SHBG hormone hormones men women non-alcoholic fatty liver fatty liver CVD cardiovascular disease cardiovascular disease

shared by Nathan Goodyear on 02 Feb 15 - No Cached

Nathan Goodyear on 02 Feb 15

Time that physicians start following the science. Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women. Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women. The opposite was found to be true in men. Higher Estradiol levels were found to be associated with increased fatty liver in both sexes. However, the statistical significance was higher with men. Higher SHBG was associated with lower fatty liver incidence in men.

<div class="cArrow"> </div><div class="cContentInner">Time that physicians start following the science. Study using data from the Multi-ethnic Study of Atherosclerosis was used to assess hormones and fatty liver in men and women. Increasing bioavailable Testosterone levels in women was found to be associated with increasing fatty liver in post-menopausal women. The opposite was found to be true in men. Higher Estradiol levels were found to be associated with increased fatty liver in both sexes. However, the statistical significance was higher with men. Higher SHBG was associated with lower fatty liver incidence in men. </div>

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http://press.endocrine.org/doi/pdf/10.1210/jc.2014-2934 - 0 views

press.endocrine.org/...jc.2014-2934

androgens hormone hormones cardiovascular disease CVD cardiovascular disease Testosterone DHEA dehydroepiandrosterone men women adipose tissue fat mass SHBG