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Nathan Goodyear

Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. - PubMed - NCBI - 0 views

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    Leptin inhibits hormone production from the adrenal cortex, but increases catecholamine release from the adrenal medulla.
Nathan Goodyear

Stress Sensitivity in Metastatic Breast Cancer: Analysis of Hypothalamic-Pituitary-Adre... - 0 views

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    salivary cortisol and DHEA used to evaluate hypothalamic-pituitary changes in cancer survivors to predict survival
Nathan Goodyear

Salivary cortisol for assessment of hypothalamic-p... [Neuroimmunomodulation. 2009] - P... - 0 views

  • Sampling for salivary cortisol determination is a sensitive, specific and pain-free procedure and it is therefore very useful for following healthy and sick children before, during and after pharmacological interventions
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    Salivary cortisol for assessment of hypothalamic-pituitary-adrenal axis function.
Nathan Goodyear

Reliability of hypothalamic-pituitary-adrena... [Eur J Epidemiol. 2011] - PubMed - NCBI - 0 views

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    Study finds salivary cortisol testing is "reliable" measure of chronic cortisol production.  This study found similarity between diurnal cortisol and dexamethasone suppressed cortisol and adrenal gland volume based on literature review.
Nathan Goodyear

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal respon... - 0 views

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    repeated stress results in down regulation of central stress response ie. blunted CRH response.
Nathan Goodyear

Salivary cortisol determined by enzyme immunoassay... [Clin Endocrinol (Oxf). 2005] - P... - 0 views

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    Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortisol for assessment of dynamic hypothalamic--pituitary--adrenal axis activity.
Nathan Goodyear

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic w... - 0 views

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    Those with chronic pain shown to have HPA dysfunction.  Elevated cortisol was found via saliva evaluation.  This with pain had the higher cortisol levels.
Nathan Goodyear

Hypothalamic-pituitary-adrenal axis, neuroendorine factors and stress - 0 views

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    Great review on how stress effects the neuroimmunoendocrine systems.
Nathan Goodyear

The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity:... - 0 views

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    Very nice article on the thoughts currently involving stress, overactivity of the HPA axis and obesity.
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 0 views

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    European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 1 views

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    salivary cortisol testing said to be "first-line" and preferable to serum cortisol evaluation
Nathan Goodyear

The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecul... - 0 views

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    Good review of the interaction between the HPA stress response and the immune system.
Nathan Goodyear

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. - P... - 0 views

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    Leptin inhibits CRH, thus decreasing the HPA axis.
Nathan Goodyear

Diurnal cortisol rhythm and fatigue in breast canc... [Psychoneuroendocrinology. 2005] ... - 0 views

  • Results suggest a subtle dysregulation in hypothalamic-pituitary-adrenal axis functioning in breast cancer survivors with persistent fatigu
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    salivary cortisol predictive of fatigue in breast cancer survivors
Nathan Goodyear

Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortiso... - 0 views

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    salivary testing of cortisol proven to be a better test than blood cortisol.  Published in Clinical Endocrinology, '05.  Salivary cortisol testing is best test to evaluate cortisol levels.
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

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    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

Overtraining Syndrome - 0 views

  • Alterations in the HPA and hypothalamic-pituitary-gonadal axes with a resultant decrease in testosterone:cortisol ratios have been implicated in OTS. Proinflammatory cytokines are potent activators of the HPA system, which cause release of corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol. These cytokines suppress testosterone through central inhibition
  • Some have suggested that a decreased testosterone:cortisol ratio can be diagnostic of NFO and/or OTS. However, the ratio represents the physiologic strain of training rather than the athlete’s maladaption to that stress
  • Cortisol (catabolic and anti-inflammatory) is converted to inactive cortisone by 11β-HSD2
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  • A prospective study found a clinically significant increase in overnight urinary cortisol:cortisone ratio during a high training load period in triathletes, who subsequently underperformed and reported fatigue
  • It is proposed that cytokines may inhibit 11β-HSD2 activity and result in relative increases in cortisol and, hence, catabolism
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    Overtraining syndrome described.
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