Group items tagged

LC-MS/MS shown to be reliable in salivary cortisol evaluation.  Obese individuals create special challenges with regards to coritsol levels, due to peripheral cortisol to cortisone conversion.   This study points out that saliva should not be used solely in the diagnosis of Cushing's syndrome due to unreferenced norms.   That however, doesn't nullify salivary cortisol.  It requires a look at the references.  for those that are obese and being evaluated for cushing's.  There is no perfect test.  T This study is a little misleading in its conclusion.  Salivary testing is valid, but the reference ranges in the obese with suspected cushing's syndrome needs further evaluation: according to these authors.

Salivary hormone testing again shown to gold standard.  This study looked at salivary cortisol levels in those with Cushing's disease, Cushing's syndrome, and with adrenal incidentaloma.   The results make one scratch their head.  The sensitivity and specificities of salivary cortisol were very high, exceeding at least 94% with most > 96 and 97%.  So, why the opposition?  Ignorance I guess.

Saliva is "most useful" for those suspected of Cushing's syndrome and those followed after surgery for Cushing's disease.

Telomere length is shorter in active Cushing's syndrome compared to inactive Cushing's syndrome.  This suggests that elevated Cortisol is associated with shorter Telomere length.

good review of Cushing's syndrome and Cushing's disease

midnight salivary cortisol by electrochemiluminescence immunoassay shown to have sensitivity of 100% and specificity of 97.4% in Cushing's syndrome

specificity of saliva/salivary cortisol testing for Cushing's syndrome is 100%; but sensitivity was 69%.  Testing not done via LC-MS which is the gold standard.  This could explain the low sensitivity as compared to other studies.

salivary cortisol testing recommended as first-line test for Cushing's syndrome due to "high diagnostic accuracy".  So, I wonder why so many state medical boards and insurance companies have missed this one?

elevated cortisol associated with Cushing's syndrome suppresses TSH.

Cortisol Salivary testing shown to be test of choice for diagnosis of Cushing's syndrome

salivary cortisol validated in Cushing's Syndrome.  Multiple studies have done the same

"cortisol measurement is therefore a primary method of choice in the screening of patients suspected of having Cushing's syndrome".  This study compared plasma, salivary, and urinary tests.  salivary testing of cortisol is settled. Safe, reliable, and preferred method of evaluation.

Salivary cortisol for screening of Cushing's syndrome in children.

salivary cortisol shown to be good test to evaluate suspected Cushing's Syndrome.  Has high reproducibility and diagnostic performance.  

Salivary cortisol shown to have "high sensitivity and specificity" in subclinical and overt Cushing's syndrome. Again, why the opposition to saliva??? Ignorance.

salivary cortisol correlates with serum cortisol in Cushing's syndrome.  I posted the abstract previously.  This is the full article.

European Journal of Endocrinology finds that salivary cortisol can be used as a diagnostic tool for Cushing's syndrome and adrenal insufficiency.  Thus both hypercortisol and hypocortisol states can be followed using saliva.  This statement was using immunoassay.  Mass spectroscopy provides even better results

salivary cortisol testing shown to be 100% sensitive for the diagnosis of Cushing's syndrome

meta-analysis reveals specificity of 96% and sensitivity of 92% for late-night cortisol diagnosis of Cushing's syndrome 

salivary cortisol is shown to be reliable for both Addison's and Cushing's Syndrome