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Methadone use in men is associated with significant reduction in serum Total Testosterone levels in men.  In women, just the opposite is true, though this did not reach statistical significance.  The higher the dose of methadone in men, the lower the Testosterone.  The link between opiates and low T in men is very strong.  This is the first that I am aware of that points to the opposite effect in women.

Opioid use, despite type (including methadone), is associated with lower Testosterone in men.  This is not new information, but this meta-analysis reconfirms this relationship, particularly that methadone has the same effect.  This relationship was not found in women.  These physicians that regularly prescribe opiates  to men are doing them an incredible disservice.  A lower T in men is a significant negative health biomarker.

Methadone suppresses Testosterone in men.

This study of inner city men found low T associated with methadone use.  Narcotics are a known risk factor for low T.  The free T was calculated from serum.  This equilibrium dialysis is based on too many variables.  Look at the studies on equilibrium dialysis.  This study also found calculated free T was not associated with insulin resistance.  However, insulin resistance is a peripheral tissue dysfunction not a serum dysfunction.  So, a calculated free T (not reality) in the serum shows me nothing of the peripheral activity.  For example, inflammation has been shown to increase aromatase activity in the prostate tissue only.  The thinking in the conclusions of so many of these studies is soooo flawed.

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