Availability of evidence of benefits on overall survival and quality of life of cancer ... - 0 views
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Although the goal of cancer treatment is to improve the quantity and quality of life,123 clinical trials designed to gain regulatory approval for new drugs often evaluate indirect or “surrogate” measures of drug efficacy. These endpoints show that an agent has biological activity, but they are not reliable surrogates for improved survival4567891011 or quality of life46111213
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two recent systematic reviews suggest that the strength of association between surrogates in cancer clinical trials and life extension is generally low
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Available data from the US show that only a small proportion of cancer treatments approved by the US Food and Drug Administration (FDA) unequivocally show benefits on survival or quality of life.30
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