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Nathan Goodyear

Xanthohumol, a chalcon derived from hops, ... [Mol Nutr Food Res. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20087858

xanthohumol NF-KappaB inflammation liver NAFLD

shared by Nathan Goodyear on 03 Jan 13 - No Cached
  • Nathan Goodyear on 03 Jan 13
     
    xanthohumol again shows to inhibit NF-kappaB.  This time in individuals with NAFLD and chronic liver disease.  The effect was shwon to be dose dependent, without plateau with dosing up to 50 Mcriomoloar
Nathan Goodyear

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, ... - 0 views

atvb.ahajournals.org/...972.full

inflammation insulin resistance obesity GLUT4 receptor IL-1B TNF-alpha NF-KappaB

shared by Nathan Goodyear on 17 Oct 12 - No Cached
  • Nathan Goodyear on 17 Oct 12
     
    The summary statement of this article says it all: "chronic inflammatory state may induce insulin resistance and endothelial dysfunction..."  Inflammation causes insulin dysfunction. And in fact, we know this to be true.  We know that IL-1B and TNF-alpha stimulated by NF-KappaB actually inhibits insulin action via disruption of the GLUT4 receptor.
Nathan Goodyear

Regulatory effects of estriol on T cell migra... [J Neuroimmunol. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11958828

Estriol E3 inflammation NF-kappaB Th2 T-cells rheumatoid arthritis RA MS multiple

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    Pregnancy is a immunosuppressive state.  Estriol therapy mimics that through decrease in T cell migration and activation.  Estriol moved the Tcells to a Th2 dominance and also was found to inhibit NF-kappaB.  Estriol decreased TNF-alpa through IL-10 production.
Nathan Goodyear

Dehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus ... - 0 views

endo.endojournals.org/...3250.long

DHEA DHEA-S diabetic rats NF-KappaB inflammation hippocampus brain

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    Fascinating article: DHEA found to decrease NF-KappaB activity in the hippocampus region of the brain.  This has implications in protecting the brain.  In this study, the implication was reduction in inflammation in the hippocampus region in diabetic rat model.
Nathan Goodyear

Dehydroepiandrosterone-Sulfate Inhibits Nuclear Factor-κB-Dependent Transcrip... - 0 views

jcem.endojournals.org/...3449.long

DHEA DHEA-S inflammation NF-KappaB antioxidant

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    DHEA inhibits NF-kappaB, thus inhibiting inflammation.
Nathan Goodyear

Sleep Loss Activates Cellular Inflammatory Signaling - 0 views

www.biologicalpsychiatryjournal.com/...abstract

insomnia sleep loss inflammation NF-KappaB

shared by Nathan Goodyear on 24 Jan 12 - No Cached
  • Nathan Goodyear on 24 Jan 12
     
    lack of sleep increases inflammation.  This study showed how one night of sleep disruption can stimulate NF-KappaB activation and thus inflammation.
Nathan Goodyear

Innate Immune Pathway Links Obesity to Insulin Resistance - 0 views

circres.ahajournals.org/...1531.full

insulin resistance FFA obesity innate immune system TLR4 NF-kappaB inflammation cytokines inflammatory

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    insulin resistance leads to excess FFA, obesity and activation of the innate immune signaling.  This uses TLR4  and stimulates NF-KappaB transcription.  The result is inflammation and associated inflammatory disease conditions.
Nathan Goodyear

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Indu... - 0 views

circres.ahajournals.org/...1589.short

inflammation insulin resistance obesity FFA saturated fat TLR4 NF-kappaB IKK-Beta

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    high saturated fat intake (excess FFA) shown to contribute to obesity through TLR4 receptors.  TLR4 receptors are mediators in the innate immunity.   The result will be both IKK-Beta and NF-KappaB.
Nathan Goodyear

Short-term feeding of baicalin inhibits age-... [Mech Ageing Dev. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16766019

skullcap baicalin NF-KappaB inflammation oxidative stress aging Cox-2 iNOS

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    Baicalin, component of skullcap, shown to inhibit NF-kappaB activation
Nathan Goodyear

Curcumin attenuates the development of allergic airway inflammation and hyper-responsiv... - 0 views

www.greenmedinfo.com/...ation-and-hyper-responsiveness

curcumin inflammtion airway allergy allergies NF-KappaB asthma

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    curcumin shown to inhibit allergic airway inflammation, through NF-kappaB inhibition.  This has implications in asthma flares.
Nathan Goodyear

Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopoly... - 0 views

www.ncbi.nlm.nih.gov/...PMC2803303

cordyceps LPS inflammtion obesity DM Diabetes IL-1beta IL-6 TNF-alpha NF-KappaB

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    cordyceps shown to decrease LPS stimulated macrophage inflammation.  Specifically, IL-1Beta, IL-6, TNF-alpha were shown to be inhibited.  Also, NF-kappaB inhibition was found with cordyceps
Nathan Goodyear

Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse mode... - 0 views

www.greenmedinfo.com/...ibit-breast-cancer-mouse-model

curcumin NF-KappaB inflammation breast cancer CA

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    curcumin shown to augment paclitaxel in breast cancer treatment.  Specifically, NF-kappaB inhibition resulted in reduction in tumor size, decreased tumor cell proliferation, increased apoptosis, and decreased MM-9.
Nathan Goodyear

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in... - 0 views

endo.endojournals.org/...5340.full

LPS lipopolysaccharides inflammation obesity NF-KappaB insulin resistance IR

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    proposed model of how LPS stimulates NF-kappaB activation and the inflammatory cascade.  This plays a key role in the obesity epidemic.
Nathan Goodyear

Low Doses of Lipopolysaccharide and Minimally Oxidized Low-Density Lipoprotei... - 0 views

circres.ahajournals.org/...56.full

LPS oxidized LDL inflammation macrophages NF-KappaB AP-1 atherosclerosis CAD

shared by Nathan Goodyear on 26 Sep 12 - No Cached
  • Nathan Goodyear on 26 Sep 12
     
    LPS and minimal oxidized LDL have synergistic effects on inflammatory signaling.  Together the two promote inflammatory signaling from macrophages at much lower levels than either one alone.  They do this through macrophage NF-KappaB and AP-1 pathways.  And this resultant inflammation promotes atherosclerosis.  Where does all this start?  our diet and our gut.
Nathan Goodyear

http://rheumatology.oxfordjournals.org/content/49/11/2024.full.pdf - 0 views

rheumatology.oxfordjournals.org/...2024.full.pdf

EGCG epigallocatechin-3-gallate green tea NF-kappaB inflammation scleroderma autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG found to reduce extra cellular matrix production, fibrosis, and NF-kappaB activity in those with scleroderma.
Nathan Goodyear

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Re... - 0 views

www.jbc.org/...32833.long

DHEA dehydroepiandrosterone inflammation TNF-alpha NF-KappaB PPAR-alpha

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA inhibits NF-kappaB stimulated TNF-alpha production through regulation of PPAR-alpha.
Nathan Goodyear

Efficacy and mechanism of action of turmeric supplements in the treatment of experiment... - 0 views

onlinelibrary.wiley.com/...abstract

Curcumin Tumeric NF-KappaB inflammation arthritis

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    Tumeric inhibits NF-KappaB and thus inflammation in arthritis model.
Nathan Goodyear

Stress proteins and glial cell functions durin... [Neurochem Res. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22130689

aluminum AL NF-kappaB inflammation TNF-alpha glial cells glia microglia brain neurology vaccines vaccinations curcumin

shared by Nathan Goodyear on 25 Nov 13 - No Cached
  • Nathan Goodyear on 25 Nov 13
     
    aluminum shown to significantly increase NF-kappaB activity and TNF-alpha release from glial cells.  This study also found a reduction with concomitant dosing of curcumin.  All those claiming aluminum in vaccines has no side effects are without merit.
Nathan Goodyear

Boswellic acid exerts antitumor effects in co... [Carcinogenesis. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22983985

Boswellia Frankincense cancer NF-kappaB 5-lipoxygenase

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Boswellia, Frankincense, shown to have anti-tumor effects in colorectal cancer.  The effects were found against 5-lipoxygenase and NF-kappaB.  This article proposes that effects are through a modulation of specific microRNA pathways.
Nathan Goodyear

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metas... - 0 views

www.ncbi.nlm.nih.gov/...PMC3371140

pancreatic cancer pancreatic cancer HIF-1alpha NF-kappaB GLUT4 GLUT1 Graviola Soursop Annona Muricata

shared by Nathan Goodyear on 17 Oct 13 - No Cached
  • Nathan Goodyear on 17 Oct 13
     
    New insight to new therapy for Pancreatic cancer.  This article/study does a great job of reviewing the biochemistry by which Graviola works against pancreatic cancer.  Graviola was shown to downregulate HIF-1alpha, NF-kappaB, GLUT1, GLUT4, HKII, and LDHA.  Complex 1 of the electron transport was also inhibited.
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