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Nathan Goodyear

Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metas... - 0 views

www.ncbi.nlm.nih.gov/...PMC3371140

pancreatic cancer pancreatic cancer HIF-1alpha NF-kappaB GLUT4 GLUT1 Graviola Soursop Annona Muricata

shared by Nathan Goodyear on 17 Oct 13 - No Cached
  • Nathan Goodyear on 17 Oct 13
     
    New insight to new therapy for Pancreatic cancer.  This article/study does a great job of reviewing the biochemistry by which Graviola works against pancreatic cancer.  Graviola was shown to downregulate HIF-1alpha, NF-kappaB, GLUT1, GLUT4, HKII, and LDHA.  Complex 1 of the electron transport was also inhibited.
Nathan Goodyear

Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxy... - 0 views

vitamin C HIF-1alpha KRAS Pyruvate dehydrogenase kinase colorectal cancer GLUT pyruvate dehydrogenase cancer HIF SVCT

shared by Nathan Goodyear on 16 Mar 21 - No Cached
  • Nathan Goodyear on 16 Mar 21
     
    In KRAS + CRC, vitamin C downregulates PDK GLUT1, thereby increasing PD increasing Acetyl CoA production.
Nathan Goodyear

Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic... - 0 views

cancerandmetabolism.biomedcentral.com/...s40170-022-00288-7

melanoma malignant melanoma NRAS BRAF ketogenic diet

shared by Nathan Goodyear on 17 Apr 23 - No Cached
  • Nathan Goodyear on 17 Apr 23
     
    Ketogenic diet (low carb/high fats) slows malignant melanoma proliferation no matter the genomic mutations present. It matches with most BRAF+ as this points to increased GLUT1 expression.
Nathan Goodyear

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy - 1 views

www.ncbi.nlm.nih.gov/...PMC5067498

DCA dichloroacetate dichloracetic acid cancer colon cancer

shared by Nathan Goodyear on 18 Jan 18 - No Cached
  • inhibition of mitochondrial pyruvate dehydrogenase kinase
  • inhibition of aerobic glycolysis (the Warburg effect) and activation of mitochondrial potassium ion channels
  • angiogenesis blockade
  • ...5 more annotations...
  • changes in expression of HIF1-α
  • alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53
  • DCA as a cancer stabilizing agent
  • A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention
  • measurable benefits from DCA therapy in 60%-70% of cases
  • Nathan Goodyear on 18 Jan 18
     
    Good review of dichloracetate or DCA in antitumor activity.  DCA has been shown to have numerous anticancer properties.
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