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Nathan Goodyear

Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorect... - 0 views

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    Vitamin D3 shown to reduce CRP, TNF, IL-6, IL-1B, IL-8 in colorectal adenoma patients. This study supports the anti-inflammatory, anti-cancer benefits of vitamin D3.
Nathan Goodyear

Obesity - Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Stea... - 0 views

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    This study looks at the effects of capsaicin on inflammation and obesity.  Capsaicin decreases IL-1B, IL-6, TNF-alpha and MCP-1.  This reduces insulin and leptin levels, as well as increase adiponectin activity.  This article also briefly discusses curcumin, which has similar activity.
Nathan Goodyear

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes - 0 views

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    elevated  inflammatory markers, IL-1B, IL-6, and TNF-alpha, found to be associated with the development of type II Diabetes.
Nathan Goodyear

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, ... - 0 views

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    The summary statement of this article says it all: "chronic inflammatory state may induce insulin resistance and endothelial dysfunction..."  Inflammation causes insulin dysfunction. And in fact, we know this to be true.  We know that IL-1B and TNF-alpha stimulated by NF-KappaB actually inhibits insulin action via disruption of the GLUT4 receptor.
Nathan Goodyear

Metabolic Syndrome and Urologic Diseases - 0 views

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    Inflammation, TNF-alpha and IL-1B, reduces testosterone production.  Metabolic Syndrome, an inflammatory disease, shown to be associated low Testosterone.
Nathan Goodyear

Effects of testosterone supplementation on markers of the metabolic syndrome and inflam... - 0 views

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    Testosterone replacement found to reduce inflammation (Il-1B, TNF-alpha, and CPR) in men with metabolic syndrome.  Testosterone was also shown to reduce insulin and leptin as well.
Nathan Goodyear

The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid P... - 0 views

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    Testosterone replacement in men with low T found to reduce inflammatory cytokines TNF-alpha and IL-1B.
Nathan Goodyear

Zinc deficiency induces production of the proinflammatory cytokines IL-1β and... - 0 views

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    Zinc deficiency results in increase in IL-1B, TNF-alpha, and IL-6
Nathan Goodyear

Endotoxemia-induced inflammation and the effect on... [Crit Care. 2010] - PubMed - NCBI - 0 views

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    LPS endotoxemia shown to induce brain inflammation.  In this study, the inflammatory cytokine upregulation did not fully explain the septic encephalopathy so often found.  It was associated with elevated cortisol, which has been shown to shrink the hippocampus
Nathan Goodyear

High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Mono... - 0 views

  • HG significantly increased the expression of monocyte chemoattractant protein-1 (MCP-1), TNF-α, β2-integrin, interleukin-1β, and others. HG treatment increased transcription of the MCP-1 gene, MCP-1 protein levels, and adhesion of THP-1 cells to endothelial cells. HG-induced MCP-1 mRNA expression and monocyte adhesion were blocked by specific inhibitors of oxidant stress, protein kinase C, ERK1/2, and p38 mitogen-activated protein kinases
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    High glucose associated with significant increase in inflammatory signaling.
Nathan Goodyear

Regulation of Cyclooxygenase-2 Expression in Monocytes by Ligation of the Receptor for ... - 0 views

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    good article on the biochemistry of COX2 in inflammation.  Particularily with AGE and it the receptors RAGE.  COX2 has been shown to decrease insulin secretion through inhibition of islet cell production, but in the presence of disease level inflammation, COX2 can be a part of a very dangerous autocrine/paracrine loop.
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