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Nathan Goodyear

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects aga... - 0 views

www.ncbi.nlm.nih.gov/...PMC3616313

NAD nicotinamide riboside metabolism obesity SIRT sirtuins

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    nicotinamide riboside shown to offset the negative metabolic effects of American diet induced obesity.  NAD also increased SIRT1 and SIRT3 activity
Nathan Goodyear

Nebulized Glutathione Induces Bronchoconstriction in Patients with Mild Asthma (ATS Jou... - 0 views

www.atsjournals.org/...ajrccm.156.2.9611001

asthma glutathione GSH GSH peroxidase

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • Nathan Goodyear on 07 Jul 16
     
    Study finds that nebulizer glutathione in mild asthma induces bronchoconstriction.  This despite the knowledge that glutathione peroxidase activity is known to be depressed in those with asthma.  The severity of the asthma of the individuals included in this study might explain the finding.
Nathan Goodyear

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal ... - 0 views

digital.lib.washington.edu/...4415

HCG testosterone ITT intratesticular testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dose HCG, given every other day, shown to maintain intratesticular testosterone levels (ITT) in this with testosterone induced suppression.  A high ITT:T ratio is needed for appropriate spermatogenesis.
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Probiotics for t... - 0 views

jama.jamanetwork.com/article.aspx

probiotics antibiotic induced diarrhea diearrhea antibiotic treatment prevention

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    probiotics shown to not only prevent antibiotic induced diarrhea; but to be effective as a treatment. 
Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : The potential biological mechanis... - 0 views

www.sciencedirect.com/...S0041008X04001309

arsenic exposure diabetes potential pharmacology

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) is upregulated
  • these two cytokines have been well known for their effect on the induction of insulin resistance
  • Oxidative stress has been suggested as a major pathogenic link to both insulin resistance and β cell dysfunction through mechanisms involving activation of nuclear factor-κB (NF-κB), which is also activated by low levels of arsenic
  • Nathan Goodyear on 06 Dec 11
     
    discussion of possible mechanisms of arsenic induced diabetes
Nathan Goodyear

Adipose Tissue Inflammation in Obesity and Metabolic Syndrome - - Satoshi Nishimura - D... - 0 views

www.discoverymedicine.com/...obesity-and-metabolic-syndrome

inflammation obesity metabolic syndrome fat adipose tissue innate immune system humoral

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Activation of inflammatory pathways in adipocytes impairs triglyceride storage and increases release of free fatty acids, an excess of which is known to induce insulin resistance in muscle and liver
  • recent studies have shown that large numbers of macrophages infiltrate obese adipose tissue,
  • It has been postulated that a paracrine loop involving free fatty acids and inflammatory cytokines establishes a vicious cycle between adipocytes and macrophages that propagates the inflammation
  • ...5 more annotations...
  • not only does interrupting the accumulation of macrophages within obese adipose tissue suppresses adipose inflammation in various animal models, it also ameliorates systemic insulin resistance and metabolic abnormalities, suggesting macrophages are key effector cells involved in adipose inflammation
  • Thus, obese visceral adipose tissue is clearly a site of chronic inflammation
  • activation of the leukocyte adhesion cascade, a hallmark of inflammation
  • CD8+ T cells within obese adipose tissue induce activation and migration of monocytes/macrophages, and in cooperation with the adipose tissue, they also induce macrophage differentiation. At the same time, obese adipose tissue activates CD8+ T cells, creating a vicious cycle involving CD8+ T cells, macrophages, and obese adipose tissue that propagates local inflammation
  • In obese adipose tissue there is a shift to dominance of CD8+ and TH1 T cells, which appears to propagate inflammation
  • Nathan Goodyear on 21 Dec 11
     
    fascinating read how the immune system and resultant inflammation results in obesity.
Nathan Goodyear

Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehr397.abstract

endurance training athletes cardiac heart right ventricular function

shared by Nathan Goodyear on 28 Jan 12 - No Cached
  • Nathan Goodyear on 28 Jan 12
     
    endurance training found to induce heart dysfunction.  This was all in the right ventricular function, but significant dysfunction was found.
Nathan Goodyear

drug-induced nutrient depletions - 1 views

www.northlandak.com/d_Nutrient_Depletions_TM-1.pdf

prescription drugs nutrient depletions vitamins minerals mineral

shared by Nathan Goodyear on 06 Feb 12 - No Cached
  • Nathan Goodyear on 06 Feb 12
     
    Good list of drug-induced nutrient depletions
Nathan Goodyear

Endotoxemia-induced inflammation and the effect on... [Crit Care. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20444270

LPS endotoxemia inflammation brain TNF-alpha IL-6 IL-10 IL-1B cortisol

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    LPS endotoxemia shown to induce brain inflammation.  In this study, the inflammatory cytokine upregulation did not fully explain the septic encephalopathy so often found.  It was associated with elevated cortisol, which has been shown to shrink the hippocampus
Nathan Goodyear

Curcumin-induced Apoptosis of Human Colon Cancer Colo 205 Cells through the Production ... - 0 views

ar.iiarjournals.org/...4379.short

colon colon cancer cancer curcumin tumeric

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Curcumin found to induce apoptosis, cell death, of colon cancer cells.
Nathan Goodyear

Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

www.ajandrology.com/article.asp

Testosterone male obesity overweight men hormone hormones low T Low T

shared by Nathan Goodyear on 15 Jan 14 - No Cached
  • The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
  • Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
  • By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
  • ...37 more annotations...
  • diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
  • bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
  • The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
  • Reductions in testosterone levels correlate with the severity of obesity and men
  • epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
  • healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
  • obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
  • Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
  • although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
  • SHBG increases with age
  • marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
  • adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
  • diabetic obesity is associated with decreases in circulatory E 2
  • In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
  • In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
  • weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
  • fat is androgen-responsive
  • low testosterone may augment the effects of a hypercaloric diet
  • In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
  • Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
  • in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
  • severe sex steroid deficiency can increase fat mass rapidly
  • bidirectional relationship between testosterone and obesity
  • increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
  • androgens may play a more significant role in VAT than SAT
  • men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
    • Nathan Goodyear
      Nathan Goodyear on 16 Jan 14
       
      Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  • irisin, derived from muscle, induces brown fat-like properties in rodent white fat
  • androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
  • low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
  • pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
  • Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
  • observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
  • genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
  • A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
  • men, regardless of obesity level, can benefit from the effect of weight loss.
  • inconsistent effect of testosterone on VAT
  • Nathan Goodyear on 15 Jan 14
     
    to be read
Nathan Goodyear

Glycine Accelerates Recovery from Alcohol-Induced Liver Injury - 0 views

jpet.aspetjournals.org/...1014.long

glycine liver damage cirrhosis alcohol

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Glycine shortens recovery time in alcohol induced injury.
Nathan Goodyear

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Ins... - 0 views

diabetes.diabetesjournals.org/...1986.long

TLR-4 TLR4 toll like receptors high fat diet LPS endotoxin insulin resistance IR obesity

shared by Nathan Goodyear on 20 Jul 13 - No Cached
  • Nathan Goodyear on 20 Jul 13
     
    HFD and LPS endotoxin induce inflammation through TLR-4 to increase insulin resistance and obesity.
Nathan Goodyear

Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resin... - 0 views

www.ncbi.nlm.nih.gov/...PMC3538159

essential oils oil essential oil essential oils pancreatic cancer cancer Boswellia sacra Frankincense

shared by Nathan Goodyear on 30 Nov 13 - No Cached
  • Nathan Goodyear on 30 Nov 13
     
    In vitro studies find that Boswellia sacra, also known as Frankincense, induces cell death of pancreatic cancer cells.
Nathan Goodyear

BMC Complementary and Alternative Medicine | Full text | Frankincense essential oil pre... - 0 views

www.biomedcentral.com/...253

alternative alternative medicine essential oil oils Boswellia Frankincense pancreatic cancer cancer

shared by Nathan Goodyear on 01 Dec 13 - No Cached
  • Nathan Goodyear on 01 Dec 13
     
    Boswellia sacra, Frankincense, proves to induce pancreatic cancer cell death in vitro.
Nathan Goodyear

Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effe... - 0 views

www.jbc.org/...23111.long

HIF-1alpha cancer Hypoxia-inducible Factor 1

shared by Nathan Goodyear on 17 Oct 13 - No Cached
  • HIF-1 activation is highly associated with cancer cell growth and survival, tumor development, tumor angiogenesis, and poor clinical prognosis
  • The adaptation of cancer cells to hypoxia is mediated via hypoxia-inducible Factor 1 (HIF-1),1 a key transcription factor that up-regulates a series of genes involved in glycolytic energy metabolism, angiogenesis, cell survival, and erythropoiesis. Included among these genes are vascular endothelial growth factor (VEGF), erythropoietin (EPO), glucose transporters (GLUT), and several glycolytic enzymes (12, 13).
  • Nathan Goodyear on 17 Oct 13
     
    good discussion of HIF-1alpha and cancer
Nathan Goodyear

http://www.2ndchance.info/onesize4all-Perricone2013.pdf - 0 views

www.2ndchance.info/onesize4all-Perricone2013.pdf

aluminum Macrophagic myofasciitis ASIA autoimmune disease autoimmune disease Autoimmune_inflammatory syndrome induced by adjuvants vaccines vaccinations

shared by Nathan Goodyear on 03 Apr 14 - No Cached
  • Nathan Goodyear on 03 Apr 14
     
    Absolute must read!  Science. That is what physicians are.  Eliminate politics and bias.  Aluminum, common adjuvant in vaccines and well known neurotoxin, has been linked to post vaccine macrophagic myofascitis.  Now, world experts have placed it at the forefront of a new created syndrome "ASIA" which is autoimmune/inflammatory syndrome induced by adjuvants.  
Nathan Goodyear

Ginsenoside Rg3 Alleviates Lipopolysaccharide-Induced Learning and Memory Impairments b... - 0 views

www.ncbi.nlm.nih.gov/...PMC3825202

RG3 inflammation brain memory learning ginsenoside panax ginseng panax ginseng TNF-alpha IL-1beta cox-2 cognition

shared by Nathan Goodyear on 10 Apr 14 - No Cached
  • Nathan Goodyear on 10 Apr 14
     
    Rat model induced inflammatory reaction in brain via LPS injection.  The result was impaired memory.  RG3 from panax ginseng was shown to reduce inflammation, TNF-alpha, IL-1beta, cox-2, thus improving memory and cognitive function.
Nathan Goodyear

Hypertension induced by methyl mercur... [Toxicol Appl Pharmacol. 1987] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3590186

Hg mercury hypertension cardiovascular disease

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Hg induces hypertension in rat model.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15721881

Pb lead SOD CAT GPX detoxification superoxide disumutase catalase glutathione glutathione peroxidase

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb induces dysfunction of SOD, CAT, and GPX.
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